The N-benzyl derivative of the glucosidase inhibitor 1-deoxynojirimycin shows a prolonged half-life and a more complete oral absorption in the rat compared with the N-methyl analog

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 5, Issue 1, 1998, Pages 3-12

  Faber, Esther D ^a   Van Den Broek, Leon A G M ^b   Oosterhuis, Ellen E Z ^a   Stok, Bert P ^a   Meijer, Dirk K F ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b NV ORGANON   (Netherlands)

Author keywords

Bioavailability; Glucosidase inhibitor; Isolated perfused rat liver; N benzyl l deoxynojirimycin; Pharmacokinetics; Rats; Subcellular fractionation

Indexed keywords

1 DEOXY N METHYLNOJIRIMYCIN; 1 DEOXYNOJIRIMYCIN DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; ANTIVIRUS AGENT; CARBON 14; GLUCOSIDASE; N BENZYL 1 DEOXYNOJIRIMYCIN; ORG 32360; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG UPTAKE; DRUG URINE LEVEL; ENDOSOME; ISOLATED LIVER; LIPOPHILICITY; LIVER LYSOSOME; MALE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT;

EID: 0031977166     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549809052021     Document Type: Article

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