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For a complimentary approach, see: Maly, D. J.; Choong, I. C.; Ellman, J. A. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 2419-2424.
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Blackwell, H. E.; O'Leary, D. J.; Chatterjee, A. K.; Washenfelder, R. A.; Bussman, D. A.; Grubbs, R. H. J. Am. Chem. Soc. 2000, 122, 58-71 and references therein.
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(b) Nicolaou, K. C.; Hughes, R.; Cho, S. Y.; Winssinger, N.; Smethurst, C.; Labischinski, H.; Endermann, R. Angew. Chem., Int. Ed. 2000, 39, 3823-3828.
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(a) Boger, D. L.; Chai, W.; Jin, Q. J. Am. Chem. Soc. 1998, 120, 7220-7225.
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(b) Giger, T.; Wigger, M.; Audétat, S.; Benner, S. A. Synlett 1998, 688-691.
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(d) Gierasch, T. M.; Chytil, M.; Didiuk, M. T.; Park, J. Y.; Urban, J. J.; Nolan, S. P.; Verdine, G. L. Org. Lett. 2000, 2, 3999-4002.
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0029903708
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For cross-metathesis examples, see: (a) Schuster, M.; Pernerstorfer, J.: Blechert, S. Angew. Chem., Int. Ed. Engl. 1996, 35, 1979-1980.
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Schuster, M.1
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(b) van Maarseveen, J. H.; den Hartog, J. A. J.; Engelen, V.; Finner, E.; Visser, G.; Kruse, C. G. Tetrahedron Lett. 1996, 37, 8249-8252.
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Den Hartog, J.A.J.2
Engelen, V.3
Finner, E.4
Visser, G.5
Kruse, C.G.6
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0042789856
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Boston, MA.; American Chemical Society: Washington, DC, ORGN
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(c) O'Leary, D. J.; Blackwell, H. E.; Deegan, T. L.; Porco, J. A.; Grubbs, R. H. Abstracts of Papers, 216th National Meeting of the American Chemical Society, Boston, MA.; American Chemical Society: Washington, DC, 1998; ORGN 186.
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O'Leary, D.J.1
Blackwell, H.E.2
Deegan, T.L.3
Porco, J.A.4
Grubbs, R.H.5
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(a) Schuster, M.; Pernerstorfer, J.; Blechert, S. Angew. Chem., Int. Ed. Engl. 1996, 35, 1979-1980. van Maarseveen, J. H.; den Hartog, J. A. J.; Engelen, V.; Finner, E.; Visser, G.; Kruse, C. G. Tetrahedron Lett. 1996, 37, 8249-8252.
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(a) Schuster, M.; Pernerstorfer, J.; Blechert, S. Angew. Chem., Int. Ed. Engl. 1996, 35, 1979-1980. van Maarseveen, J. H.; den Hartog, J. A. J.; Engelen, V.; Finner, E.; Visser, G.; Kruse, C. G. Tetrahedron Lett. 1996, 37, 8249-8252.
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(b) Conde-Frieboes, K.; Anderson, S.; Breinholt, J. Tetrahedron Lett. 2000, 41, 9153-9156.
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Washington, DC; American Chemical Society: Washington, DC, ORGN
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Blackwell, H. E.; Clemons, P. A.; Schreiber, S. L. Abstracts of Papers, 220th National Meeting of the American Chemical Society, Washington, DC; American Chemical Society: Washington, DC, 2000; ORGN 330.
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220th National Meeting of the American Chemical Society
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Blackwell, H.E.1
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(a) Fridikin, M.; Patchornik, A.; Katchalski, E. J. Am. Chem. Soc. 1965, 87, 4646-4648.
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For two recent reports of site-site interactions, see: (a) Yan, B.; Sun, Q. J. Org. Chem. 1998, 63, 55-58.
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(b) Lindsley, C. W.; Chan, L. K.; Goess, B. C.; Joseph, R.; Shair, M. D. J. Am. Chem. Soc. 2000, 122, 422-423.
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34
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0041787682
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in press
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Tallarico, J. A.; Depew, K. M.; Pelish, H. E.; Westwood, N. J.; Lindsley, C. J.; Shair, M. D.; Schreiber, S. L.; Foley, M. A. J. Comb. Chem., in press.
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Foley, M.A.8
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35
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0041287103
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submitted for publication
-
These PS 500-600 μm beads are capable of delivering ca. 0.1 mg of product, following a diversity synthesis, on a per bead basis. Blackwell, H. E.; Pérez, L., et al., submitted for publication.
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Blackwell, H.E.1
Pérez, L.2
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37
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0042789855
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Cleavage of the FMOC group from aliquots of resin-bound alcohols (2a-d) with 20% piperidine/DMF and quantitation of the released fulvene product by UV spectroscopy revealed reproducible loadings of 0.7-0.9 mmol/g resin
-
Cleavage of the FMOC group from aliquots of resin-bound alcohols (2a-d) with 20% piperidine/DMF and quantitation of the released fulvene product by UV spectroscopy revealed reproducible loadings of 0.7-0.9 mmol/g resin.
-
-
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38
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0041787679
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Authentic samples of dimers 5a and 5c were prepared using the solution-phase cross-metathesis protocol reported in ref 9
-
Authentic samples of dimers 5a and 5c were prepared using the solution-phase cross-metathesis protocol reported in ref 9.
-
-
-
-
39
-
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0041787681
-
-
All new compounds exhibited satisfactory spectroscopic data
-
All new compounds exhibited satisfactory spectroscopic data.
-
-
-
-
40
-
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0041287102
-
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1H NMR spectra; the predominant olefin isomer was assigned as trans. See ref 9
-
1H NMR spectra; the predominant olefin isomer was assigned as trans. See ref 9.
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-
-
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41
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0033521136
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These contaminated polymer beads were not active as immobilized metathesis catalysts; see: Ahmed, M.; Barrett, A. G. M.; Braddock, D. C.; Cramp, S. M.; Procopiou, P. Tetrahedron Lett. 1999, 40, 8657-8662.
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Ahmed, M.1
Barrett, A.G.M.2
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Cramp, S.M.4
Procopiou, P.5
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42
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0042288761
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Use of the methylidene analogue of ruthenium benzylidene 3a should also eliminate this impurity
-
Use of the methylidene analogue of ruthenium benzylidene 3a should also eliminate this impurity.
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44
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0034678033
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Schreiber, S. L. Science 2000, 287, 1964-1969.
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Science
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46
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0041787678
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-
All of the library building blocks have been chosen so that the resulting dimeric compounds will have molecular weights in the range of 500-800 g/mol, which could improve their chances of cell permeability. The projected library size is ca. 10 000 members
-
All of the library building blocks have been chosen so that the resulting dimeric compounds will have molecular weights in the range of 500-800 g/mol, which could improve their chances of cell permeability. The projected library size is ca. 10 000 members.
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-
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50
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0032541735
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Lacombe, P.; Castagner, B.; Gareau, Y.; Ruel, R. Tetrahedron Lett. 1998, 39, 6785-6786.
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