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Volumn 3, Issue 8, 2001, Pages 1185-1188

Exploiting site-site interactions on solid support to generate dimeric molecules

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING SITE; CHEMICAL MODEL; DIMERIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; ORGANIC CHEMISTRY; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 0035912363     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol015647i     Document Type: Article
Times cited : (47)

References (51)
  • 1
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    • Heldin, C.-H. Cell 1995, 80, 213-223.
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, C.-H.1
  • 22
    • 0029903708 scopus 로고    scopus 로고
    • (a) Schuster, M.; Pernerstorfer, J.; Blechert, S. Angew. Chem., Int. Ed. Engl. 1996, 35, 1979-1980. van Maarseveen, J. H.; den Hartog, J. A. J.; Engelen, V.; Finner, E.; Visser, G.; Kruse, C. G. Tetrahedron Lett. 1996, 37, 8249-8252.
    • (1996) Angew. Chem., Int. Ed. Engl. , vol.35 , pp. 1979-1980
    • Schuster, M.1    Pernerstorfer, J.2    Blechert, S.3
  • 32
    • 0003008165 scopus 로고    scopus 로고
    • For two recent reports of site-site interactions, see: (a) Yan, B.; Sun, Q. J. Org. Chem. 1998, 63, 55-58.
    • (1998) J. Org. Chem. , vol.63 , pp. 55-58
    • Yan, B.1    Sun, Q.2
  • 35
    • 0041287103 scopus 로고    scopus 로고
    • submitted for publication
    • These PS 500-600 μm beads are capable of delivering ca. 0.1 mg of product, following a diversity synthesis, on a per bead basis. Blackwell, H. E.; Pérez, L., et al., submitted for publication.
    • Blackwell, H.E.1    Pérez, L.2
  • 37
    • 0042789855 scopus 로고    scopus 로고
    • Cleavage of the FMOC group from aliquots of resin-bound alcohols (2a-d) with 20% piperidine/DMF and quantitation of the released fulvene product by UV spectroscopy revealed reproducible loadings of 0.7-0.9 mmol/g resin
    • Cleavage of the FMOC group from aliquots of resin-bound alcohols (2a-d) with 20% piperidine/DMF and quantitation of the released fulvene product by UV spectroscopy revealed reproducible loadings of 0.7-0.9 mmol/g resin.
  • 38
    • 0041787679 scopus 로고    scopus 로고
    • Authentic samples of dimers 5a and 5c were prepared using the solution-phase cross-metathesis protocol reported in ref 9
    • Authentic samples of dimers 5a and 5c were prepared using the solution-phase cross-metathesis protocol reported in ref 9.
  • 39
    • 0041787681 scopus 로고    scopus 로고
    • All new compounds exhibited satisfactory spectroscopic data
    • All new compounds exhibited satisfactory spectroscopic data.
  • 40
    • 0041287102 scopus 로고    scopus 로고
    • 1H NMR spectra; the predominant olefin isomer was assigned as trans. See ref 9
    • 1H NMR spectra; the predominant olefin isomer was assigned as trans. See ref 9.
  • 42
    • 0042288761 scopus 로고    scopus 로고
    • Use of the methylidene analogue of ruthenium benzylidene 3a should also eliminate this impurity
    • Use of the methylidene analogue of ruthenium benzylidene 3a should also eliminate this impurity.
  • 44
  • 46
    • 0041787678 scopus 로고    scopus 로고
    • All of the library building blocks have been chosen so that the resulting dimeric compounds will have molecular weights in the range of 500-800 g/mol, which could improve their chances of cell permeability. The projected library size is ca. 10 000 members
    • All of the library building blocks have been chosen so that the resulting dimeric compounds will have molecular weights in the range of 500-800 g/mol, which could improve their chances of cell permeability. The projected library size is ca. 10 000 members.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.