메뉴 건너뛰기




Volumn 3, Issue 1, 1999, Pages 112-115

Design and discovery of protein dimerizers

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CELL SURFACE RECEPTOR; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; HORMONE; PROTEIN; SB 247464; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 0033016407     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(99)80020-9     Document Type: Note
Times cited : (47)

References (28)
  • 1
    • 0028535607 scopus 로고
    • Making agonists of antagonists
    • B Seed Making agonists of antagonists Chem Biol 1 1994 125 129
    • (1994) Chem Biol , vol.1 , pp. 125-129
    • Seed, B1
  • 2
    • 0028533869 scopus 로고
    • Proximity versus allostery: the role of regulated protein dimerization in biology
    • DJ Austin GR Crabtree SL Schreiber Proximity versus allostery: the role of regulated protein dimerization in biology Chem Biol 1 1994 131 136
    • (1994) Chem Biol , vol.1 , pp. 131-136
    • Austin, DJ1    Crabtree, GR2    Schreiber, SL3
  • 3
    • 0031892994 scopus 로고    scopus 로고
    • Dimerization as a regulatory mechanism in signal transduction
    • JD Klemm SL Schreiber GR Crabtree Dimerization as a regulatory mechanism in signal transduction Annu Rev Immunol 16 1998 569 592
    • (1998) Annu Rev Immunol , vol.16 , pp. 569-592
    • Klemm, JD1    Schreiber, SL2    Crabtree, GR3
  • 4
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • CH Heldin Dimerization of cell surface receptors in signal transduction Cell 80 1995 213 223
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, CH1
  • 6
    • 0004235781 scopus 로고
    • Cellular and Molecular Immunology
    • A Abbas A Lichtman J Pober Cellular and Molecular Immunology edn 2 1994 WB Saunders Company New York
    • (1994)
    • Abbas, A1    Lichtman, A2    Pober, J3
  • 7
    • 0026574559 scopus 로고
    • T cell receptor aggregation, but not dimerization, induces increased cytosolic calcium concentrations and reveals a lack of stable association between CD4 and the T cell receptor
    • MJ Ratcliffe KM Coggeshall MK Newell MH Julius T cell receptor aggregation, but not dimerization, induces increased cytosolic calcium concentrations and reveals a lack of stable association between CD4 and the T cell receptor J Immunol 148 1992 1643 1651
    • (1992) J Immunol , vol.148 , pp. 1643-1651
    • Ratcliffe, MJ1    Coggeshall, KM2    Newell, MK3    Julius, MH4
  • 8
    • 0027965825 scopus 로고
    • JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization
    • H Rui JJ Lebrun RA Kirken PA Kelly WL Farrar JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization Endocrinology 135 1994 1299 1306
    • (1994) Endocrinology , vol.135 , pp. 1299-1306
    • Rui, H1    Lebrun, JJ2    Kirken, RA3    Kelly, PA4    Farrar, WL5
  • 9
    • 0028116305 scopus 로고
    • Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
    • Z Fan Y Lu X Wu J Mendelsohn Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells J Biol Chem 269 1994 27595 27602
    • (1994) J Biol Chem , vol.269 , pp. 27595-27602
    • Fan, Z1    Lu, Y2    Wu, X3    Mendelsohn, J4
  • 10
    • 0029742943 scopus 로고    scopus 로고
    • Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies
    • S Elliott T Lorenzini D Yanagihara D Chang G Elliott Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies J Biol Chem 271 1996 24691 24697
    • (1996) J Biol Chem , vol.271 , pp. 24691-24697
    • Elliott, S1    Lorenzini, T2    Yanagihara, D3    Chang, D4    Elliott, G5
  • 11
    • 0032086337 scopus 로고    scopus 로고
    • Targeting growth factor and cytokine receptors with recombinant peptide libraries
    • WJ Dower Targeting growth factor and cytokine receptors with recombinant peptide libraries Curr Opin Chem Biol 2 1998 328 334
    • (1998) Curr Opin Chem Biol , vol.2 , pp. 328-334
    • Dower, WJ1
  • 12
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin–cyclosporin A and FKBP–FK506 complexes
    • J Liu JD Farmer Jr WS Lane J Friedman I Weissman SL Schreiber Calcineurin is a common target of cyclophilin–cyclosporin A and FKBP–FK506 complexes Cell 66 1991 807 815
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J1    Farmer, JD2    Lane, WS3    Friedman, J4    Weissman, I5    Schreiber, SL6
  • 15
    • 0030878873 scopus 로고    scopus 로고
    • Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen
    • SD Liberles ST Diver DJ Austin SL Schreiber Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen Proc Natl Acad Sci USA 94 1997 7825 7830
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7825-7830
    • Liberles, SD1    Diver, ST2    Austin, DJ3    Schreiber, SL4
  • 16
    • 0027756895 scopus 로고
    • Controlling signal transduction with synthetic ligands
    • DM Spencer TJ Wandless SL Schreiber GR Crabtree Controlling signal transduction with synthetic ligands Science 262 1993 1019 1024
    • (1993) Science , vol.262 , pp. 1019-1024
    • Spencer, DM1    Wandless, TJ2    Schreiber, SL3    Crabtree, GR4
  • 17
    • 0030759476 scopus 로고    scopus 로고
    • Single-step syntheses of cell permeable protein dimerizers that activate signal transduction and gene expression
    • ST Diver SL Schreiber Single-step syntheses of cell permeable protein dimerizers that activate signal transduction and gene expression J Am Chem Soc 119 1997 5106 5109
    • (1997) J Am Chem Soc , vol.119 , pp. 5106-5109
    • Diver, ST1    Schreiber, SL2
  • 18
    • 0028533803 scopus 로고
    • Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012
    • MN Pruschy DM Spencer TM Kapoor H Miyake GR Crabtree SL Schreiber Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012 Chem Biol 1 1994 163 172
    • (1994) Chem Biol , vol.1 , pp. 163-172
    • Pruschy, MN1    Spencer, DM2    Kapoor, TM3    Miyake, H4    Crabtree, GR5    Schreiber, SL6
  • 19
    • 0031983955 scopus 로고    scopus 로고
    • Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment
    • J Yang K Symes M Mercola SL Schreiber Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment Curr Biol 8 1998 11 18
    • (1998) Curr Biol , vol.8 , pp. 11-18
    • Yang, J1    Symes, K2    Mercola, M3    Schreiber, SL4
  • 20
    • 0032569205 scopus 로고    scopus 로고
    • Stereoselective synthesis of over two million compounds having structural features reminiscent of natural products and compatible with miniaturized cell-based assays
    • DS Tan MA Foley MD Shair SL Schreiber Stereoselective synthesis of over two million compounds having structural features reminiscent of natural products and compatible with miniaturized cell-based assays J Am Chem Soc 120 1998 8565 8566
    • (1998) J Am Chem Soc , vol.120 , pp. 8565-8566
    • Tan, DS1    Foley, MA2    Shair, MD3    Schreiber, SL4
  • 22
    • 0025893762 scopus 로고
    • General method for rapid synthesis of multicomponent peptide mixtures
    • A Furka F Sebestyen M Asgedom G Dibo General method for rapid synthesis of multicomponent peptide mixtures Int J Pept Protein Res 37 1991 487 493
    • (1991) Int J Pept Protein Res , vol.37 , pp. 487-493
    • Furka, A1    Sebestyen, F2    Asgedom, M3    Dibo, G4
  • 23
    • 0026419328 scopus 로고
    • A new type of synthetic peptide library for identifying ligand-binding activity
    • KS Lam SE Salmon EM Hersh VJ Hruby WM Kazmierski RJ Knapp A new type of synthetic peptide library for identifying ligand-binding activity Nature 354 1991 82 84
    • (1991) Nature , vol.354 , pp. 82-84
    • Lam, KS1    Salmon, SE2    Hersh, EM3    Hruby, VJ4    Kazmierski, WM5    Knapp, RJ6
  • 24
    • 0001501146 scopus 로고
    • Two-directional chain synthesis of syn-skipped polyol chains from meso precursors
    • SL Schreiber MT Goulet G Schulte Two-directional chain synthesis of syn -skipped polyol chains from meso precursors J Am Chem Soc 109 1987 4718 4720
    • (1987) J Am Chem Soc , vol.109 , pp. 4718-4720
    • Schreiber, SL1    Goulet, MT2    Schulte, G3
  • 25
    • 0031444011 scopus 로고    scopus 로고
    • Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein–ligand interactions on a large scale
    • A Borchardt SD Liberles SR Biggar GR Crabtree SL Schreiber Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein–ligand interactions on a large scale Chem Biol 4 1997 961 968
    • (1997) Chem Biol , vol.4 , pp. 961-968
    • Borchardt, A1    Liberles, SD2    Biggar, SR3    Crabtree, GR4    Schreiber, SL5
  • 26
    • 0031472576 scopus 로고    scopus 로고
    • A miniaturized arrayed assay format for detecting small molecule–protein interactions in cells
    • AJ You RJ Jackman GM Whitesides SL Schreiber A miniaturized arrayed assay format for detecting small molecule–protein interactions in cells Chem Biol 4 1997 969 975
    • (1997) Chem Biol , vol.4 , pp. 969-975
    • You, AJ1    Jackman, RJ2    Whitesides, GM3    Schreiber, SL4
  • 27
    • 0031472251 scopus 로고    scopus 로고
    • A yeast genetic system for selecting small molecule inhibitors of protein–protein interactions in nanodroplets
    • J Huang SL Schreiber A yeast genetic system for selecting small molecule inhibitors of protein–protein interactions in nanodroplets Proc Natl Acad Sci USA 94 1997 13396 13401
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13396-13401
    • Huang, J1    Schreiber, SL2
  • 28
    • 0033080348 scopus 로고    scopus 로고
    • High throughput post-transcriptional and biosynthetic profiling using small molecules in miniaturized mammalian cell based assays
    • BR Stockwell SJ Haggarty SL Schreiber High throughput post-transcriptional and biosynthetic profiling using small molecules in miniaturized mammalian cell based assays Chem Biol 6 1999 71 83
    • (1999) Chem Biol , vol.6 , pp. 71-83
    • Stockwell, BR1    Haggarty, SJ2    Schreiber, SL3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.