Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases

International Immunology

Volumn 11, Issue 11, 1999, Pages 1801-1810

  Mitra, Dipendra K ^a,c   De Rosa, Stephen C ^a   Luke, Andrew ^b   Balamurugan, Arumugam ^c   Khaitan, Binod K ^c   Tung, James ^a   Mehra, Narinder K ^c   Terr, Abba I ^b   O'Garra, Anne ^d   Herzenberg, Leonore A ^a   Herzenberg, Leonard A ^a   Roederer, Mario ^e  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^d MERCK RESEARCH LABORATORIES   (United States)

^e NONE   (United States)

Author keywords

Cytokine profile; Flow cytometry; Intracellular cytokine staining; T(h)1; T(h)2

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PADGEM PROTEIN;

ARTICLE; ATOPY; CELL DIFFERENTIATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; HELPER CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; LEPROMATOUS LEPROSY; LEPROSY; MEMORY CELL; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TUBERCULOID LEPROSY;

CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOLOGIC MEMORY; LEPROSY, LEPROMATOUS; LEPROSY, TUBERCULOID; MALE; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS;

EID: 0032742642     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.11.1801     Document Type: Article

References (46)

1. Baumgarth, N., Egerton, M. and Kelso, A. 1997. Activated T cells from draining lymph nodes and an effector site differ in their responses to TCR stimulation. J. Immunol., in press.
2. + T cell subset expressing homing receptor L-selectin. J. Immunol. 152:4417.
3. + T cells. Immunology 87:186.
4. Roederer, M., Rosa, S. D., Gerstein, R., Anderson, M., Bigos, M., Stovel, R., Nozaki, T., Parks, D., Herzenberg, L. and Herzenberg, L. 1997. 8-Color, 10-parameter flow cytometry: elucidation of complex leukocyte heterogeneity. Cytometry, in press.
5. Sher, A. and Coffman, R. L. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385.
6. Romagnani, S. 1995. Atopic allergy and other hypersensitivities editorial overview: technological advances and new insights into pathogenesis prelude novel therapeutic strategies [editorial]. Curr. Opin. Immunol. 7:745.
7. Corrigan, C. J. 1995. Elevated interleukin-4 secretion by T lymphocytes: a feature of atopy or of asthma? [editorial]. Clin. Exp. Allergy 25:485.
8. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
9. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227.
10. Umetsu, D. T., Jabara, H. H., DeKruyff, R. H., Abbas, A. K., Abrams, J. S. and Geha, R. S. 1988. Functional heterogeneity among human inducer T cell clones. J. Immunol. 140:4211.
11. Yamamura, M., Uyemura, K., Deans, R. J., Weinberg, K., Rea, T. H., Bloom, B. R. and Modlin, R. L. 1991. Definitive protective responses to pathogens: cytokine profiles in leprosy lesions [published erratum appears in Science 1992; 255(5040): 12]. Science 254:277.
12. Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L. and Bloom, B. R. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279.
13. Bloom, B., Salgame, R and Diamond, B. 1992. Revisiting and revising suppressor T cells. Immunol. Today 13:131.
14. Haanen, J. B., de Waal Malefijt, R., Res, P. C., Kraakman, E. M., Ottenhoff, T. H., de Vries, R. R. and Spits, H. 1991. Selection of a human T helper type 1-like T cell subset by mycobacteria. J. Exp. Med. 174:583.
15. Misra, N., Murtaza, A., Walker, B., Narayan, N. P., Misra, R. S., Ramesh, V., Singh, S., Colston, M. J. and Nath, I. 1995. Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by relating antigens of Mycobacterium leprae. Immunology 86:97.
16. + T cells. Clin. Immunol. Immunopathol. 82:60.
17. Del Prete, G. F., Der Carli, M., Mastromauro, C., Biagiotti, R., Macchia, D., Falagiani, P., Ricci, M. and Romagnani, S. 1991. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J. Clin. Invest. 88:346.
18. Parronchi, P., Macchia, D., Piccinni, M. P., Biswas, P., Simonelli, C., Maggi, E., Ricci, M., Ansari, A. A. and Romagnani, S. 1991. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc. Natl Acad. Sci. USA 88:4538.
19. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
20. + T cell clones. J. Immunol. 148:738.
21. + T cells in target organs and in the allergen-specific repertoire of allergic patients. Possible role of IL-4 produced by non-T cells. Int. Arch. Allergy Appl. Immunol. 94:133.
22. Ridley, D. and Jopling, W. 1966. Classification of leprosy according to immunity; a five-group system. Int. J. Lepr. 34:255.
23. Walcheck, B., Kahn, J., Fisher, J. M., Wang, B. B., Fisk, R. S., Payan, D. G., Feehan, C., Betageri, R., Darlak, K., Spatola, A. F. and Kishimoto, T. K. 1996. Neutrophil rolling altered by inhibition of L-selectin shedding in vitro. Nature 380:720.
24. Roederer, M., Bigos, M., Nozaki, T., Stovel, R. T., Parks, D. R. and Herzenberg, L. A. 1995. Heterogeneous calcium flux in peripheral T cell subsets revealed by five-color flow cytometry using log-ratio circuitry. Cytometry 21:187.
25. Picker, L. J., Singh, M. K., Zdraveski, Z., Treer, J. R., Waldrop, S. L., Bergstresser, P. R. and Maino, V. C. 1995. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 86:1408.
26. Roederer, M., Raju, P. A., Mitra, D. K., Herzenberg, L. A. and Herzenberg, L. A. 1997. HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28. J. Clin. Invest. 9:1555.
27. Azuma, M., Cayabyab, M., Buck, D., Phillips, J. H. and Lanier, L. L. 1993. CD28 interaction with B7 co-stimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J. Exp. Med. 175:353.
28. Picker, L., Treer, J., Ferguson, D., Collins, P., Buck, D. and Terstappen, L. 1993. Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J. Immunol. 150:1105.
29. high T cell population. Eur. J. Immunol. 23:1057.
30. Roederer, M., Dubs, J. G., Anderson, M. T., Raju, P. A. Herzenberg, L. A. and Herzenberg, L. A. 1995. CD8 naive T cell counts decrease progressively in HIV-infected adults. J. Clin. Invest. 95:2061.
31. + T helper type 2 cells. J. Exp. Med. 181:5.
32. + subset activity in vivo. J. Immunol. 151:48.
33. h2 paradigm: insights from leprosy. J. Invest. Dermatol. 102:828.
34. Sieling, P. A. and Modlin, R. L. 1994. Cytokine patterns at the site of mycobacterial infection. Immunobiology 191:378.
35. Mocci, S. and Coffman, R. L. 1997. The mechanism of in vitro T helper cell type 1 to T helper cell type 2 switching in highly polarized Leishmania major-specific T cell populations. J. Immunol. 158:1559.
36. Mathewson, J. J. and DuPont, H. L. 1996. Impaired TH1-like immune response in Schistosoma mansoni infection [letter]. J. Infect Dis. 174:677.
37. h2 cells. J. Exp. Med. 185:817.
38. Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D. H., Gubler, U. and Sinigaglia, F. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825.
39. Austrup, F., Vestweber, D., Borges, E., Lohning, M., Brauer, R., Herz, U., Renz, H., Hallmann, R., Scheffold, A., Radbruch, A. and Hamann, A. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. Nature 385:81.
40. + T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J. Exp. Med. 182:1579.
41. Paul, W. E. and Seder, R. A. 1994. Lymphocyte responses and cytokines. Cell 76:241.
42. Abbas, A. K., Murphy, K. M. and Sher, A. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
43. O'Garra, A. and Murphy, K. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6:458.
44. Scott, B., Liblau, R., Degermann, S., Marconi, L. A., Ogata, L., Caton, A. J., McDevitt, H. O. and Lo, D. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1:73.
45. Oro, A. S., Guarino, T. J., Driver, R., Steinman, L. and Umetsu, D. T. 1996. Regulation of disease susceptibility: decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis. J. Allergy Clin. Immunol. 97:1402.
46. Shirakawa, T., Enomoto, T., Shimazu, S. and Hopkin, J. M. 1997. The inverse association between tuberculin responses and atopic disorder. Science 275:77.