Evidence That the Two C1q Binding Membrane Proteins, gC1q-R and cC1q-R, Associate to Form a Complex

Journal of Immunology

Volumn 159, Issue 3, 1997, Pages 1429-1436

  Ghebrehiwet, Berhane ^a   Lu, Phoebe D ^a   Zhang, Weibing ^a   Keilbaugh, Sue A ^a   Leigh, Leonora E A ^b   Eggleton, Paul ^b   Reid, Kenneth B M ^b   Peerschke, Ellinor I B ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPOLYMER; BIOTIN; C1QBP PROTEIN, HUMAN; CARRIER PROTEIN; COMPLEMENT 1Q RECEPTOR; COMPLEMENT COMPONENT C1Q; COMPLEMENT RECEPTOR; HERMES ANTIGEN; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL;

AMINO ACID SEQUENCE; ARTICLE; BINDING COMPETITION; CELL CULTURE; CELL FRACTIONATION; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, CD44; BINDING, COMPETITIVE; BIOPOLYMERS; BIOTIN; CARRIER PROTEINS; COMPLEMENT C1Q; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MEMBRANE GLYCOPROTEINS; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOLS; PROTEIN BINDING; RECEPTORS, COMPLEMENT; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED;

EID: 0031201043     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Ghebrehiwet, B., L. Silvestri, and C. McDevitt. 1984. Identification of the Raji cell membrane-derived C1q inhibitor as a receptor for C1q: purification and immunochemical characterization. J. Exp. Med. 160:1375.
2. Malhotra, R., and R. B. Sim. 1989. Chemical and hydrodynamic characterization of the human leucocyte receptor for complement subcomponent C1q. Biochem. J. 262:625.
3. Malhotra, R., A. C. Willis, J.-C. Jensenius, J. Jackson, and R. B. Sim. 1993. Structure and homology of human C1q receptor (collectin receptor). Immunology 78:34.
4. Ghebrehiwet, B., B. L. Lim, E. I. B. Peerschke, A. C. Willis, and K. B. M. Reid. 1994. Isolation cDNA cloning, and overexpression of a 33-kDa cell surface glycoprotein that binds to the globular 'heads' of C1q. J. Exp. Med. 179:1809.
5. Guo, N., K. N. Sastry, B.-L. Lim, W. Schwaeble, N. Lynch, E. I. B. Peerschke, K. B. M. Reid, and B. Ghebrehiwet. 1996. Human C1q globular domain receptor (gC1q-R) gene: cloning, characterization and localization to chromosome 17. Mol. Immunol. 33(Suppl. 1):6.
6. Malhotra, R., J. Lu, S. Thiel, J-C. Jensenius, A. C. Willis, and R. B. Sim. 1992. C1q receptor (collectin receptor): primary structure, homology, and interaction with ligands. Immunobiology 184:437.
7. Eggleton, P., T. S. Lieu, E. G. Zappi, K. Sastry, J. Coburn, K. S. Zaner, R. D. Sontheimer, J. D. Capra, B. Ghebrehiwet, and A. I. Tauber. 1994. Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. Clin. Immunol. Immunopathol. 72:405.
8. Sontheimer, R. D., T. Q. Nguyen, S.-T. Cheng, T.-S. Lieu, and J. D. Capra. 1995. The unveiling of calreticulin: a clinically relevant tour of modern cell biology. J. Invest. Med. 43:362.
9. McCauliffe, D. P., F. A. Lux, T.-S. Lieu, I. Sanz, J. Hanke, M. N. Newkirk, L. L. Bachinski, Y. Itoh, M. J. Siciliano, M. Reichlin, R. D. Sontheimer, and J. D. Capra. 1990. Molecular cloning and chromosome 19 localization of a human Ro/SS-A autoantigen. J. Clin. Invest. 85:1379.
10. Rokeach, L. A., J. A. Haselby, J. F. Meilof, R. J. T. Smeenk, T. R. Unnasch, B. M. Greene, and S. O. Hoch. 1991. Characterization of the autoantigen calreticulin. J. Immunol. 147:3031.
11. Pulvertaft, R. J. V. 1965. A study of malignant tumors in Nigeria by short-term tissue culture. J. Clin. Pathol. 18:261.
12. Wallis, W. J., D. D. Hickstein, B. R. Schwartz, C. H. June, H. D. Ochs, P. G. Beatty, S. J. Klebanoff, and J. M. Harlan. 1986. Monoclonal antibody-defined functional epitopes on the adhesion-promoting glycoprotein complex (CDw18) of human neutrophils. Blood 67:1007.
13. Back, A. L., W. W. Kwok, M. Adam, S. J. Collins, and D. D. Hickstein. 1990. Retroviral-mediated gene transfer of the leukocyte integrin CD18 subunit. Biochem. Biophys. Res. Commun. 17:787.
14. Back, A. L., W. W. Kwok, and D. D. Hickstein. 1992. Identification of two molecular defects in a child with leukocyte adherence deficiency. J. Biol. Chem. 267:5482.
15. Hickstein, D. D., E. Grunvald, G. Shumaker, D. M. Baker, A. L. Back, L. J. Embree, E. Yee, and K. A. Gollahon. 1993. Transfected leukocyte integrin CD11b/CD18 (Mac-1) mediates phorbol ester activated, homotypic cell: cell adherence in the K562 cell line. Blood 82:2537.
16. Lim, B.-L., K. Preissner, B. Ghebrehiwet, L. E. A. Leigh, and K. B. M. Reid. 1996. The binding protein for globular "heads" of complement C1q, gC1q-R: functional expression and characterization as a novel vitronectin binding factor. J. Biol. Chem. 271:26739.
17. Ghebrehiwet, B., P. D. Lu, W. Zhang, B.-L. Lim, P. Eggleton, L. A. E. Leigh, K. B. M. Reid, and E. I. B. Peerschke. 1996. Identification of functional domains on gC1q-R, a cell surface protein that binds to the globular "heads" of C1q using monoclonal antibodies and synthetic peptides. Hybridoma 15:333.
18. Cole, S. R., L. K., Ashmand, and P. L. Ey. 1987. Biotinylation: an alternative to radioiodination for the identification of cell surface antigens in immunoprecipitates. Mol. Immunol. 24:699.
19. Kennett, R. H. 1980. Enzyme-linked antibody assay with cells attached to polyvinyl chloride plates. In Monoclonal Antibodies. R. H. Kennett, T. J. McKearn, and K. B. Bechtol, eds. Plenum Press, New York, p. 376.
20. Ghebrehiwet, B. 1986. Production and characterization of a murine monoclonal IgM antibody to human C1q receptor (C1q-R). J. Immunol. 137:618.
21. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature 227:680.
22. Low, M. G., J. Steinberg, G. L. Waneck, R. A. Flavell, and P. W. Kincade. 1988. Cell-specific heterogeneity in sensitivity of phosphatidylinositol-anchored membrane antigens to release by phospholipase C. J. Immunol. Methods 113:101.
23. Low, M. G. 1989. The glycosyl-phosphatidylinositol anchor of membrane proteins. Biochim. Biophys. Acta 988:427.
24. Ghebrehiwet, B., K. Peterson, E. I. B. Peerschke, S. R. Reddigari, and K. B. M. Reid. 1994. Purification and immunochemical characterization of soluble forms of the two types of C1q receptors: cC1q-R and gC1q-R. FASEB J. 8:A475.
25. 3 integrins (GPIIb/IIIa) and the expression of P-selectin and procoagulant activity. J. Exp. Med. 178:579.
26. Ghebrehiwet, B., R. R. Kew, B. L. Gruber, M. J. Marchese, E. I. B. Peerschke, and K. B. M. Reid. 1995. Murine mast cells express two types of C1q receptors that are involved in the induction of chemotaxis and chemokinesis. J. Immunol. 155:2614.
27. Kuna, P., M. Iyer, E. I. B. Peerschke, A. P. Kaplan, K. B. M. Reid, and B. Ghebrehiwet. 1996. Human C1q induces eosinophil migration. Clin. Immunol. Immpathol. 81:48.
28. 2+ in mouse fibroblasts. J. Immunol. 14:3177.
29. Lozada, C., R. I. Levin, M. Huie, R. Hirschhorn, D. Naime, M. Whitlow, P. A. Recht, B. Golden, and B. N. Cronstein. 1995. Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1. Proc. Natl. Acad. Sci. USA 92:8378.
30. Chen, A., S. Gaddipati, Y. Hong, D. J. Volkman, E. I. B. Peerschke, and B. Ghebrehiwet. 1994. Human T cells express specific binding sites for C1q: role in T cell activation and proliferation. J. Immunol. 153:1430.
31. Eggleton, P., B. Ghebrehiwet, K. N. Sastry, J. P. Coburn, K. S. Zaner, K. B. M. Reid, and A. I. Tauber. 1995. Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils: subcellular localization and binding properties in comparison with cC1q-R. J. Clin. Invest. 95:1569.
32. Peerschke, E. I. B., K. B. M. Reid, and B. Ghebrehiwet. 1994. Identification of a novel 33-kDa C1q-binding site on human blood platelets. J. Immunol. 152:5896.
33. Joseph, K., B. Ghebrehiwet, E. I. B. Peerschke, K. B M. Reid, and A. P. Kaplan. 1996. Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor which binds to the globular "heads" of C1q (gC1q-R). Proc. Natl. Acad. Sci. USA 93:8552.
34. Sim, R. B., G. J. Arlaud, and M. Colomb. 1979. C1 inhibitor-dependent dissociation of human complement component C1 bound to immune complexes. Biochem. J. 179:449.
35. Peerschke, E. I. B., and B. Ghebrehiwet. 1992. Platelet interactions with C1q in whole blood and in the presence of immune complexes or aggregated IgG. Clin. Immunol. Immunopathol. 63:45.