Evidence that C1q binds specifically to C(H)2-like immunoglobulin γ motifs present in the autoantigen calreticulin and interferes with complement activation

Biochemistry

Volumn 37, Issue 51, 1998, Pages 17865-17874

  Kovacs, Helena ^a,d   Campbell, Iain D ^a   Strong, Peter ^b   Johnson, Steven ^a,b   Ward, Frank J ^c   Reid, Kenneth B M ^b   Eggleton, Paul ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CALRETICULIN; COMPLEMENT COMPONENT C1Q; FC RECEPTOR; IMMUNOGLOBULIN G; SYNTHETIC PEPTIDE;

AMINO ACID SEQUENCE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNE DISEASE; COMPLEMENT ACTIVATION; COMPLEMENT FIXATION; ENDOPLASMIC RETICULUM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; AUTOANTIGENS; BINDING SITES, ANTIBODY; BINDING, COMPETITIVE; BIOTIN; CALCIUM-BINDING PROTEINS; CALRETICULIN; COMPLEMENT C1Q; COMPLEMENT HEMOLYTIC ACTIVITY ASSAY; COMPLEMENT PATHWAY, CLASSICAL; HEMOLYSIS; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN HEAVY CHAINS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEINS;

EID: 0032559021     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi973197p     Document Type: Article

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