Effect of Saquinavir on proliferation and telomerase activity of human peripheral blood mononuclear cells

Life Sciences

Volumn 69, Issue 13, 2001, Pages 1509-1520

  Franzese, O ^a   Lombardi, A ^a   Comandini, A ^a   Cannavo E ^b   Testorelli, C ^c   Cirello, I ^c   Bonmassar, E ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Interferon; Lymphocytes; Saquinavir; T cells; Telomerase

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; SAQUINAVIR; TELOMERASE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA SYNTHESIS; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOID CELL; MONONUCLEAR CELL; NORMAL HUMAN; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; CELL DIVISION; DNA; HIV PROTEASE INHIBITORS; HUMANS; INTERFERON TYPE II; NEUTROPHILS; PHYTOHEMAGGLUTININS; SAQUINAVIR; TELOMERASE;

EID: 0035902873     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01243-7     Document Type: Article

References (43)

1. Complete remission of AIDS-related Kaposi's sarcoma associated with undetactable human herpersvirus-8 sequences during anti-HIV protease therapy
2. Complete nucleotide sequence of the AIDS virus
3. An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection
4. A synthetic HIV protease inhibitor with antiviral activity arrests HIV-like particle maturation
5. Improvement in cell-mediated immune function during potent anti-human immunodeficiency virus therapy with Ritonavir plus Saquinavir
6. Hiv protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells
7. Specific association of human telomerase activity with immortal cells and cancer
8. Essential role of mouse telomerase in highly proliferative organs
9. Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells
10. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
11. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
12. A theory of marginotomy
13. Telomeres shorten during aging of human fibroblasts
14. Telomere dynamics and telomerase activity in "in vitro" immortalised human cells
15. Up-regulation of telomerase activity in human lymphocytes
16. Mechanism of telomerase induction during T cell activation
17. Regulated expression of telomerase activity in human T lympocyte development and activation
18. Cytokine production in Saquinavir treated mice
19. Persistent alteration in T-cell repertoire cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy
20. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)
21. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity
22. Single daily doses of Saquinavir achieve HIV-inhibitory concentrations when combined with baby-dose Ritonavir
23. Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A
24. Saquinavir: An HIV proteinase inhibitor
25. Interferon-γ has dual potentials in inhibiting or promoting cell proliferation
26. Direct activation of TERT trancription by c-MYC
27. Increased CD4+ T-lymphocyte senescence fraction in advanced human immunodeficiency virus type I infection
28. Normal T-cell telomerase activity and up-regulation in human immodeficiency virus-I infection
29. Telomere length dynamics in telomerase-positive immortal human cell populations
30. Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to the antigen receptor
31. Impaired telomerase activity in uninfected haematopoietic progenitors in HIV-I infected patients
32. Rapid telomere shortening in children
33. Telomere length, telomerase activity and replicative potential in HIV infection: Analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins
34. Quantitative measurement of telomerase activity in lymphadenopathy: Correlation with histologic features and human immodeficiency virus-I infection
35. The in vivo effects of combination antiretroviral drug therapy on peripheral blood CD34+ cell colony-forming units from HIV type I-infected patients
36. Lack of immunotoxicity of Saquinavir (Ro-31-8959) used alone or in double or triple combination with AZT and ddC
37. HIV protease inhibitors restore impaired T-cell proliferative response in vivo and in vitro: A viral-suppression-independent mechanism
38. CpG oligodeoxynucleotides acts as adjuvants that switch on T helper 1 (Th1) immunity
39. Effect of protease therapy on cytokine decretion by peripheral blood mononuclear cells (PBMC) from HIV-infected subjects
40. Dynamic correlation of apoptosis and immune activation during treatment of HIV infection
41. Decreased HIV-associated T cell apoptosis by HIV protease inhibitors
42. Human Immunodeficiency Virus type 1 protease inhibitor modulates activation of peripheral blood CD4+ T cells and decreases their susceptibility to apoptosis in vitro and in vivo
43. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability