Cytokine production in saquinavir treated mice

International Journal of Immunopharmacology

Volumn 19, Issue 4, 1997, Pages 243-248

  Pacifici, Roberta ^a   Di Carlo, Simonetta ^a   Bacosi, Antonella ^a   Pichini, Simona ^a   Zuccaro, Piergiorgio ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cytokine; Inhibitor; Proteinase

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; PROTEINASE INHIBITOR; SAQUINAVIR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SPLEEN CELL;

ANIMALS; ANTI-HIV AGENTS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HIV PROTEASE INHIBITORS; INTERFERON TYPE II; INTERLEUKINS; MALE; MICE; MICE, INBRED C57BL; PHYTOHEMAGGLUTININS; SAQUINAVIR; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030735373     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(97)00031-3     Document Type: Article

References (24)

1. Allen, J. B., Wong, H. I., Guyre, P. M., Simon, G. I. & Walh, S. M. (1991) Association of circulating receptor FcγRIII-positive monocytes in AIDS patients with elevated levels of transforming grow factor-β. J. Clin. Invest., 87, 1773-1779.
2. Ashorn, P., McQuade, T. J., Thaisrivongs, S., Tomasselli, A. G., Tarpley, W. G. & Moss, B. (1990) An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection. Proc. Natl. Acad. Sci. USA, 87, 7472-7476.
3. Black, R. A., Kronbelm, S. R., Merriam, J. G., March, C. J. & Hopp, T. P. (1989) A pre-aspartate-specific protease from human leukocytes that cleaves pro-interleukin-1β. J. Biol. Chem., 264, 5323-5326.
4. Bugelski, P. J., Kaplan, J. M., Hart, T. K., Miller, J., Laydon, J. T., Lee, J. C., Dreye, G. B. & Kirsh, R. (1992) Effect of a human immunodeficiency virus protease inhibitor on human monocyte function. AIDS Res. Hum. Retroviruses, 8, 1951-1958.
5. Craig, J. C., Duncan, I. B., Hockley, D., Greif, C., Roberts, N. A. & Mills, J. S. (1991) Antiviral properties of RO 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase. Antiviral Res., 16, 295-305.
6. Del Prete, G. D. (1992) Human Th1 and Th2 lymphocytes: their role in the pathophysiology of Actopy. Allergy, 47, 450-455.
7. Farrar, W. L., Korner, M. & Clouse, K. A. (1991) Cytokine relugation of human immunodeficiency virus expression. Cytokine, 3, 531-542.
8. Guagliardi, L. E., Koppelman, B., Blum, J. S., Marks, M. S., Creewell, P. & Brodsky, F. M. (1990) Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature, 343, 133-139.
9. Harding, C. V., Unanue, E. R., Slot, J. W., Schwartz, A. L. & Geuze, H. L. (1990) Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II peptide complexes during antigen processing. Proc. Natl. Acad. Sci. USA, 87, 553-557.
10. Kadereit, S., Gewert, D. R., Galabru, J., Hovanessian, A. G. & Meurs, E. F. (1993) Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins. J. Biol. Chem., 268, 24432-24441.
11. Kay, J., Jupp, R. A., Norey, C. G., Richards, A. D., Reid, W. A., Taggart, R. T., Samloff, I. M. & Dunn, B. M. (1988) Aspartate proteinases and inhibitors for their control in health and disease. Adv. Exp. Med. Biol., 240, 1-11.
12. Kostura, M. J., Tocci, M. J., Limjuco, G., Chin, J., Cameron, P., Hillman, A. G., Chartrain, N. A. & Schmidt, J. A. (1989) Identification of a monocyte specific pre-interleukin-lβ convertase activity. Proc. Natl. Acad. Sci. USA, 86, 5227-5231.
13. Kramer, R. A., Schaber, M. D., Skalka, A. M., Ganguly, K., Wong-Staal, F. & Reddy, E. P. (1986) HTLV III in Gag protein is processed in yeast cells by the virus pol-protease. Science, 231, 1580-1584.
14. Lah, T. T., Hawley, M., Rock, K. L. & Goldberg, A. L. (1995) Gamma-nterferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett., 363, 85-89.
15. Lawrence, D. A. (1995) Transforming growth factor β: an overview. Kidney Int., 9, s19-s23.
16. McQuade, T. J., Tomasselli, A. G., Liu, L., Karacostas, V., Moss, B., Sawyer, T. K., Heinrikson, R. L. & Tarpley, W. G. (1990) A synthetic HIV protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science, 247, 454-456.
17. Noel, A. R., Craig, J. C. & Duncan, I. B. (1992) Novel approaches in HIV chemoterapy. Biochem. Soc. Trans., 20, 513-516.
18. Pearl, L. H. & Taylor, W. R. (1987) A structural model for HIV proteases. Nature, 329, 351-354.
19. Ratner, L., Haseltine, W., Patarca, R., Livak, J. K., Starcich, B., Josephs, F. J., Doran, E. R., Rafalski, J. A., Whitehorn, E. A., Baumeister, K., Ivanoff, L., Petteway, S. R., Pearson, L. M., Lautenberger, J. A., Papas, T. S., Ghayeb, J., Chang, N. T., Gallo, R. C. & Wong-Staal, F. (1985) Complete nucleotide sequence of the AIDS virus. Nature, 313, 277-282.
20. Schreurs, J. (1993) Cytokines in infections desease: the battle between host and pathogen. Curr. Opinion Biotechnol., 4, 727-733.
21. Takahashi, H., Cease, K. B. & Berzofsky, J. A. (1989) Identification of proteases that process distinct epitopes on the same protein. J. Immunol., 142, 2221-2229.
22. Wahl, S. M., Allen, J. B., McCartney-Francis, N., Morganti-Kossman, M. C., Ellingsworth, L., May, U. E. H., Mergenhagen, S. E. & Orenstein, J. M. (1991) Macrophage- and astrocyte-derived transforming growth factor β as a mediator of central nervous system dysfuction in acquired immune deficiency syndrome. J. Exp. Med., 173, 981-991.
23. Whiteside, T. L. (1994) Cytokine measurements and interpretation of cytokine assays in human desease. J. Clin. Immunol., 14, 327-339.
24. Young, H. A. & Hardy, K. J. (1995) Role of interferon-γ in immune cell regulation. J. Leukoc. Biol., 58, 373-381.