메뉴 건너뛰기




Volumn 2, Issue 5, 1999, Pages 261-269

HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells

Author keywords

Apoptosis TNF; Chronic infection; Fas ligand; Immune activation

Indexed keywords

PROTEINASE INHIBITOR; RITONAVIR;

EID: 0033504073     PISSN: 10909508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (82)

References (46)
  • 1
    • 0032499143 scopus 로고    scopus 로고
    • + cell counts despite persistently detectable HIV load
    • + cell counts despite persistently detectable HIV load. N Engl J Med 1998;338: 1074.
    • (1998) N Engl J Med , vol.338 , pp. 1074
    • Levitz, S.M.1
  • 2
    • 0031926537 scopus 로고    scopus 로고
    • Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis
    • Johnson N, Parkin JM. Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis. Clin Exp Immunol 1998;113:229.
    • (1998) Clin Exp Immunol , vol.113 , pp. 229
    • Johnson, N.1    Parkin, J.M.2
  • 3
    • 0032548547 scopus 로고    scopus 로고
    • AIDS therapy: Failure isn't what it used to be . . . but neither is success
    • Cohen J. AIDS therapy: failure isn't what it used to be . . . but neither is success [news]. Science 1998;279: 1133.
    • (1998) Science , vol.279 , pp. 1133
    • Cohen, J.1
  • 4
    • 0032547101 scopus 로고    scopus 로고
    • HIV treatment failure: Testing for HIV resistance in clinical practice
    • Perrin L, Telenti A. HIV treatment failure: testing for HIV resistance in clinical practice. Science 1998;280:1871.
    • (1998) Science , vol.280 , pp. 1871
    • Perrin, L.1    Telenti, A.2
  • 5
    • 17344365057 scopus 로고    scopus 로고
    • Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: Results of AIDS Clinical Trials Group Protocol 315
    • Lederman MM, Connick E, Landay A, et al. Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: results of AIDS Clinical Trials Group Protocol 315. J Infect Dis 1998;178:70.
    • (1998) J Infect Dis , vol.178 , pp. 70
    • Lederman, M.M.1    Connick, E.2    Landay, A.3
  • 6
    • 0030895312 scopus 로고    scopus 로고
    • Protease inhibitors in patients with HIV disease: Clinically important pharmacokinetic considerations
    • Barry M, Gibbons S, Back D, Mulcahy F. Protease inhibitors in patients with HIV disease: clinically important pharmacokinetic considerations. Clin Pharmacokinet 1997;32:194.
    • (1997) Clin Pharmacokinet , vol.32 , pp. 194
    • Barry, M.1    Gibbons, S.2    Back, D.3    Mulcahy, F.4
  • 7
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456.
    • (1995) Science , vol.267 , pp. 1456
    • Thompson, C.B.1
  • 10
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305.
    • (1998) Science , vol.281 , pp. 1305
    • Ashkenazi, A.1    Dixit, V.M.2
  • 12
    • 0031975644 scopus 로고    scopus 로고
    • The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection
    • Sloand EM, Maciejewski JP, Sato T, et al. The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection. J Clin Invest 1998;101:195.
    • (1998) J Clin Invest , vol.101 , pp. 195
    • Sloand, E.M.1    Maciejewski, J.P.2    Sato, T.3
  • 13
    • 0028265466 scopus 로고
    • High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children
    • Debatin KM, Fahrig-Faissner A, Enenkel-Stoodt S, Kreuz W, Benner A, Krammer PH. High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]. Blood 1994;83:3101.
    • (1994) Blood , vol.83 , pp. 3101
    • Debatin, K.M.1    Fahrig-Faissner, A.2    Enenkel-Stoodt, S.3    Kreuz, W.4    Benner, A.5    Krammer, P.H.6
  • 14
    • 0027497028 scopus 로고
    • Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals
    • Oyaizu N, McCloskey TW, Coronesi M, Chirmule N, Kalyanaraman VS, Pahwa S. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 1993;82:3392.
    • (1993) Blood , vol.82 , pp. 3392
    • Oyaizu, N.1    McCloskey, T.W.2    Coronesi, M.3    Chirmule, N.4    Kalyanaraman, V.S.5    Pahwa, S.6
  • 15
    • 0029048581 scopus 로고
    • Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals
    • Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 1995;181:2029.
    • (1995) J Exp Med , vol.181 , pp. 2029
    • Katsikis, P.D.1    Wunderlich, E.S.2    Smith, C.A.3    Herzenberg, L.A.4
  • 16
    • 0032128437 scopus 로고    scopus 로고
    • In vivo analysis of Fas/FasL interactions in HIV-infected patients
    • Badley AD, Dockrell DH, Algeciras A, et al. In vivo analysis of Fas/FasL interactions in HIV-infected patients. J Clin Invest 1998;102:79.
    • (1998) J Clin Invest , vol.102 , pp. 79
    • Badley, A.D.1    Dockrell, D.H.2    Algeciras, A.3
  • 17
    • 0030806976 scopus 로고    scopus 로고
    • Down-regulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy
    • Bohler T, Herr I, Debatin KM, Geiss M, Haas J. Down-regulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy [letter; comment]. Blood 1997;90:886.
    • (1997) Blood , vol.90 , pp. 886
    • Bohler, T.1    Herr, I.2    Debatin, K.M.3    Geiss, M.4    Haas, J.5
  • 18
    • 0032580479 scopus 로고    scopus 로고
    • HIV-protease inhibitors
    • Flexner C. HIV-protease inhibitors. N Engl J Med 1998; 338:1281.
    • (1998) N Engl J Med , vol.338 , pp. 1281
    • Flexner, C.1
  • 19
    • 0030052964 scopus 로고    scopus 로고
    • Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir
    • Kelleher AD, Carr A, Zaunders J, Cooper DA. Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis 1996;173:321.
    • (1996) J Infect Dis , vol.173 , pp. 321
    • Kelleher, A.D.1    Carr, A.2    Zaunders, J.3    Cooper, D.A.4
  • 20
    • 0030868897 scopus 로고    scopus 로고
    • + T cell homeostasis and function in advanced HIV disease
    • + T cell homeostasis and function in advanced HIV disease [see comments]. Science 1997;277:112.
    • (1997) Science , vol.277 , pp. 112
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 21
    • 0032505665 scopus 로고    scopus 로고
    • Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease. Immunology Study Group of Spanish EARTH-1 Study
    • Plana M, Garcia F, Gallart T, Miro JM, Gatell JM. Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease. Immunology Study Group of Spanish EARTH-1 Study [letter]. Lancet 1998;352:1194.
    • (1998) Lancet , vol.352 , pp. 1194
    • Plana, M.1    Garcia, F.2    Gallart, T.3    Miro, J.M.4    Gatell, J.M.5
  • 22
    • 0030897988 scopus 로고    scopus 로고
    • Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases
    • Margolin N, Raybuck SA, Wilson KP, et al. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J Biol Chem 1997;272: 7223.
    • (1997) J Biol Chem , vol.272 , pp. 7223
    • Margolin, N.1    Raybuck, S.A.2    Wilson, K.P.3
  • 24
    • 0032575377 scopus 로고    scopus 로고
    • Simultaneous degradation of alphaII- and betall-spectrin by caspase 3 (CPP32) in apoptotic cells
    • Wang KK, Posmantur R, Nath R, et al. Simultaneous degradation of alphaII-and betall-spectrin by caspase 3 (CPP32) in apoptotic cells. J Biol Chem 1998;273:22490.
    • (1998) J Biol Chem , vol.273 , pp. 22490
    • Wang, K.K.1    Posmantur, R.2    Nath, R.3
  • 25
    • 0027692154 scopus 로고
    • Multifactorial nature of human immunodeficiency virus disease: Implications for therapy
    • Fauci AS. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 1993;262:1011.
    • (1993) Science , vol.262 , pp. 1011
    • Fauci, A.S.1
  • 26
    • 0028131579 scopus 로고
    • Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
    • Pope M, Betjes MG, Romani N, et al. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 1994;78:389.
    • (1994) Cell , vol.78 , pp. 389
    • Pope, M.1    Betjes, M.G.2    Romani, N.3
  • 27
    • 0029655757 scopus 로고    scopus 로고
    • Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes
    • Badley AD, McElhinny JA, Leibson PJ, Lynch DH, Alderson MR, Paya CV. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 1996;70:199.
    • (1996) J Virol , vol.70 , pp. 199
    • Badley, A.D.1    McElhinny, J.A.2    Leibson, P.J.3    Lynch, D.H.4    Alderson, M.R.5    Paya, C.V.6
  • 28
    • 0031092636 scopus 로고    scopus 로고
    • + T cells apoptosis: A possible mechanism of bystander cell death in HIV infection
    • + T cells apoptosis: a possible mechanism of bystander cell death in HIV infection. J Immunol 1997;158: 2456.
    • (1997) J Immunol , vol.158 , pp. 2456
    • Oyaizu, N.1    Adachi, Y.2    Hashimoto, F.3
  • 30
    • 0030060388 scopus 로고    scopus 로고
    • Selective activation-induced apoptosis of peripheral T cells imposed by macrophages: A potential mechanism of antigen-specific peripheral lymphocyte deletion
    • Munn DH, Pressey J, Beall AC, Hudes R, Alderson MR. Selective activation-induced apoptosis of peripheral T cells imposed by macrophages: a potential mechanism of antigen-specific peripheral lymphocyte deletion. J Immunol 1996;156:523.
    • (1996) J Immunol , vol.156 , pp. 523
    • Munn, D.H.1    Pressey, J.2    Beall, A.C.3    Hudes, R.4    Alderson, M.R.5
  • 31
    • 0003539827 scopus 로고    scopus 로고
    • North Chicago, IL: Abbott Laboratories
    • Norvir, Ritonavir Product Monograph [package insert]. North Chicago, IL: Abbott Laboratories, 1997.
    • (1997) Norvir, Ritonavir Product Monograph
  • 32
    • 0028968902 scopus 로고
    • ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans
    • Kempf DJ, Marsh KC, Denissen JF, et al. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc Natl Acad Sci USA 1995;92:2484.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2484
    • Kempf, D.J.1    Marsh, K.C.2    Denissen, J.F.3
  • 33
    • 0028104156 scopus 로고
    • HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha
    • Maciejewski JP, Weichold FF, Young NS. HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha. J Immunol 1994;153:4303.
    • (1994) J Immunol , vol.153 , pp. 4303
    • Maciejewski, J.P.1    Weichold, F.F.2    Young, N.S.3
  • 34
    • 0031839955 scopus 로고    scopus 로고
    • Interferon-gamma increases expression of chemokine receptors CCR1, CCR3, and CCR5, but not CXCR4 in monocytoid U937 cells
    • Zella D, Barabitskaja O, Burns JM, et al. Interferon-gamma increases expression of chemokine receptors CCR1, CCR3, and CCR5, but not CXCR4 in monocytoid U937 cells. Blood 1998;91:4444.
    • (1998) Blood , vol.91 , pp. 4444
    • Zella, D.1    Barabitskaja, O.2    Burns, J.M.3
  • 35
    • 0027960659 scopus 로고
    • Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor- Alpha secretion
    • Oyaizu N, McCloskey TW, Than S, Hu R, Kalyanaraman VS, Pahwa S. Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion. Blood 1994;84:2622.
    • (1994) Blood , vol.84 , pp. 2622
    • Oyaizu, N.1    McCloskey, T.W.2    Than, S.3    Hu, R.4    Kalyanaraman, V.S.5    Pahwa, S.6
  • 36
    • 1842295691 scopus 로고    scopus 로고
    • HIV-1 protease inhibits its homologous reverse transcriptase by protein- Protein interaction
    • Bottcher M, Grosse F. HIV-1 protease inhibits its homologous reverse transcriptase by protein-protein interaction. Nucleic Acids Res 1997;25:1709.
    • (1997) Nucleic Acids Res , vol.25 , pp. 1709
    • Bottcher, M.1    Grosse, F.2
  • 37
    • 0030265258 scopus 로고    scopus 로고
    • The potential biological and clinical significance of the soluble tumor necrosis factor receptors
    • Aderka D. The potential biological and clinical significance of the soluble tumor necrosis factor receptors. Cytokine Growth Factor Rev 1996;7:231.
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 231
    • Aderka, D.1
  • 38
    • 13144266673 scopus 로고    scopus 로고
    • An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses
    • Andre P, Groettrup M, Klenerman P, et al. An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses. Proc Natl Acad Sci USA 1998;95:13120.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13120
    • Andre, P.1    Groettrup, M.2    Klenerman, P.3
  • 39
    • 0025600398 scopus 로고
    • Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication
    • Kobayashi N, Hamamoto Y, Yamamoto N, Ishii A, Yonehara M, Yonehara S. Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication. Proc Natl Acad Sci USA 1990;87:9620.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9620
    • Kobayashi, N.1    Hamamoto, Y.2    Yamamoto, N.3    Ishii, A.4    Yonehara, M.5    Yonehara, S.6
  • 40
    • 0028283006 scopus 로고
    • Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors
    • Sarin A, Clerici M, Blatt SP, Hendrix CW, Shearer GM, Henkart PA. Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J Immunol 1994;153:862.
    • (1994) J Immunol , vol.153 , pp. 862
    • Sarin, A.1    Clerici, M.2    Blatt, S.P.3    Hendrix, C.W.4    Shearer, G.M.5    Henkart, P.A.6
  • 41
    • 0031058025 scopus 로고    scopus 로고
    • The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication
    • Chinnaiyan AM, Woffendin C, Dixit VM, Nabel GJ. The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication. Nat Med 1997;3:333.
    • (1997) Nat Med , vol.3 , pp. 333
    • Chinnaiyan, A.M.1    Woffendin, C.2    Dixit, V.M.3    Nabel, G.J.4
  • 42
    • 0022377506 scopus 로고
    • Apoptosis, lymphocytotoxicity and the containment of viral infections
    • Clouston WM, Kerr JF. Apoptosis, lymphocytotoxicity and the containment of viral infections. Med Hypotheses 1985;18:399.
    • (1985) Med Hypotheses , vol.18 , pp. 399
    • Clouston, W.M.1    Kerr, J.F.2
  • 43
    • 0027215907 scopus 로고
    • Apoptosis reduces both the in vitro replication and the in vivo infectivity of a baculovirus
    • Clem RJ, Miller LK. Apoptosis reduces both the in vitro replication and the in vivo infectivity of a baculovirus. J Virol 1993;67:3730.
    • (1993) J Virol , vol.67 , pp. 3730
    • Clem, R.J.1    Miller, L.K.2
  • 45
    • 0030785487 scopus 로고    scopus 로고
    • A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis
    • Kolesnitchenko V, King L, Riva A, Tani Y, Korsmeyer SJ, Cohen DI. A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis. J Virol 1997;71:9753.
    • (1997) J Virol , vol.71 , pp. 9753
    • Kolesnitchenko, V.1    King, L.2    Riva, A.3    Tani, Y.4    Korsmeyer, S.J.5    Cohen, D.I.6
  • 46
    • 17444379333 scopus 로고    scopus 로고
    • Directly measured kinetics of circulating T lymphocytes in normal and HIV-1 infected humans
    • Hellerstein M, Hanley MB, Cesar D, et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1 infected humans. Nat Med 1999;5:83.
    • (1999) Nat Med , vol.5 , pp. 83
    • Hellerstein, M.1    Hanley, M.B.2    Cesar, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.