Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases

Life Sciences

Volumn 68, Issue 17, 2001, Pages 1977-1987

  Wang, Peng ^a   Wu, Ping ^a   Myers, Joyce G ^a   Stamford, Andrew ^a   Egan, Robert W ^a   Billah, M Motasim ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

cGMP; Corpus cavernosum; Erectile dysfunction; Type 5 phosphodiesterase (PDE5)

Indexed keywords

DIPYRIDAMOLE; ISOBUTYLMETHYLXANTHINE; ISOENZYME; MAGNESIUM ION; PHOSPHODIESTERASE; SILDENAFIL; THROMBOCYTE ENZYME; ZAPRINAST; ZINC ION;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DOG; DRUG POTENCY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN TISSUE; NONHUMAN; PH; RABBIT; SPECIES DIFFERENCE;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; BLOOD PLATELETS; CHROMATOGRAPHY; DIPYRIDAMOLE; DOGS; HUMANS; ISOENZYMES; KINETICS; MALE; MUSCLE, SMOOTH; PENIS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; PURINONES; RABBITS; SPECIES SPECIFICITY;

CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 0035896222     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)00989-4     Document Type: Article

References (40)

1. Nitric oxide in the penis: Physiology and pathology
2. Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle
3. Effects of the nitric oxide synthase inhibitor NG-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit
4. Intracavernous application of SIN-I in rabbit and man: Functional and toxicological results
5. Nitric oxide and cGMP: Mediators of pelvic nerve-stimulated erection in dogs
6. The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic neurotransmission in canine penile erection
7. Penile erection induced by vasoactive intestinal peptide and sodium nitroprusside
8. Intracellular mechanism of penile erection in monkeys
9. Cyclic neucleotide phosphodiesterases: Functional implications of multiple isoforms
10. Diversity in cyclic neucleotide phosphodiesterase isoenzyme families
11. Cloning and characterization of a cAMP-specific cyclic neucleotide phosphodiesterase
12. Identification and characterization of a novel family of cyclic neucleotide phosphodiesterases
13. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A
14. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
15. Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erection dysfunction
16. Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro
17. Sildenafil, a type-5 cGMP phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro
18. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells
19. Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum
20. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
21. Effects of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile function in the anesthetized dog
22. Purification of cGMP-binding protein phosphodiesterase from rat lung
23. Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase
24. Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase
25. The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung
26. Characterization of a new binding protein distinct from the kinase for guanosine 3′:5′-monophosphate in rat platelets
27. A new cGMP phosphodiesterase isolated from bovine platelets is substrate for cAMP- and cGMP-dependent protein kinases: Evidence for a key role in the process of platelet activation
28. Human blood platelet 3′:5′-cyclic nucleotide phosphodiesterase. Isolation of low-Km and high-Km phosphodiesterase
29. Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: Effects on platelet aggregation
30. HL 725, an excellent potent inhibitor of platelet phosphodiesterase and induced platelet aggregation
31. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
32. Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase
33. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′:5′-cyclic nucleotide phosphodiesterase
34. Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene
35. Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle
36. Characterization of a novel and specific inhibitor of type V phosphodiesterase
37. A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery
38. Cardiovascular activity of WIN 65579, a novel inhibitor of cyclic GMP phosphodiesterase 5
39. Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948
40. Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum