The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains

Journal of Experimental Medicine

Volumn 190, Issue 5, 1999, Pages 597-605

  Alfano, Massimo ^a   Schmidtmayerova, Helena ^a,b   Amelia, Carol Ann ^a   Pushkarsky, Tatiana ^a   Bukrinsky, Michael ^a  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

^b INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

CCR5; G1 protein; Receptor capping; Receptor desensitization; Signal transduction

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MEMBRANE PROTEIN; PERTUSSIS TOXIN; PROTEIN KINASE C INHIBITOR; RANTES;

ARTICLE; CAPPING PHENOMENON; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TARGET CELL; VIRUS CELL INTERACTION; VIRUS REPLICATION;

CALCIUM; CELLS, CULTURED; HIV-1; HUMANS; LIGANDS; MACROPHAGE INFLAMMATORY PROTEIN-1; MEMBRANE FUSION; PERTUSSIS TOXIN; RECEPTOR AGGREGATION; RECEPTORS, CCR5; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; VIRULENCE FACTORS, BORDETELLA; VIRUS REPLICATION;

EID: 0032821914     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.5.597     Document Type: Article

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