Zinc resistance impairs sensitivity to oxidative stress in HeLa cells: Protection through metallothioneins expression

Free Radical Biology and Medicine

Volumn 31, Issue 10, 2001, Pages 1179-1190

  Chimienti, Fabrice ^a,b   Jourdan, Eric ^a   Favier, Alain ^a   Seve, Michel ^a  

^a UNIV GRENOBLE ALPES   (France)

^b J Fourier   (France)

Author keywords

DNA damage; Free radicals; Metallothionein; Oxidative stress; Zinc; Zinc resistance; Zinc transport

Indexed keywords

CELL DNA; HYDROGEN PEROXIDE; METALLOTHIONEIN; ZINC ION; ZINC SULFATE;

ARTICLE; CELL CULTURE; CELL DEATH; CELL LEVEL; CELL PROTECTION; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; DNA STRAND BREAKAGE; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN LOCALIZATION;

ANTIOXIDANTS; CELL DEATH; CYTOPLASM; DNA DAMAGE; DRUG RESISTANCE; GENE EXPRESSION; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; METALLOTHIONEIN; OXIDATIVE STRESS; PROMOTER REGIONS (GENETICS); REACTIVE OXYGEN SPECIES; TRACE ELEMENTS; ZINC;

EID: 0035890214     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00701-8     Document Type: Article

References (73)

1. The biochemical basis of zinc physiology
2. Zinc fingers: DNA binding and protein-protein interactions
3. Zinc protects against oxidative damage in cultured human retinal pigment epithelial cells
4. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death
5. Zinc inhibits apoptosis upstream of ICE/CED-3 proteases rather than at the level of an endonuclease
6. 5-Aminolevulinic acid dehydratase. The role of sulphydryl groups in 5-aminolevulinic acid dehydratase from bovine liver
7. Inhibitory effect of zinc(II) on free radical lipid peroxidation in erythrocyte membranes
8. A site-specific mechanism for free radical induced biological damage: The essential role of redox-active transition metals
9. Micromolar zinc affects endonucleolytic activity in hydrogen peroxide-mediated apoptosis
10. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis
11. Role of cellular zinc in programmed cell death: Temporal relationship between zinc depletion, activation of caspases and cleavage of Sp family transcription factors
12. Zinc suppresses apoptosis of U937 cells induced by hydrogen peroxide through an increase of the Bcl-2/Bax ratio
13. A reappraisal of the role of zinc in life and death decisions of cells
14. Evidence that synaptically released zinc contributes to neuronal injury after traumatic brain injury
15. Cytotoxicity and accumulation of Hg, Ag, Cd, Cu, Pb and Zn in human peripheral T and B lymphocytes and monocytes in vitro
16. Effects of zinc on production of active oxygen species by rat neutrophils
17. Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release
18. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat
19. High levels of zinc ions induce loss of mitochondrial potential and degradation of antiapoptotic bcl-2 protein in in vitro cultivated human prostate epithelial cells
20. Metallothioneins: New functional and structural insights
21. Integrative aspects of zinc transporters
22. Metallothionein
23. The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals
24. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression
25. The function of zinc metallothionein: A link between cellular zinc and redox state
26. Regulation of metallothionein gene expression by oxidative stress and metal ions
27. Oxygen free radicals and metallothionein
28. Antioxidant role of metallothioneins: A comparative overview
29. Metallothionein protects DNA from oxidative damage
30. Metallothionein and zinc as potential antioxidants in radical-induced lipid peroxidation in cultured hepatocytes
31. Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein
32. Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)
33. An improved coupled test procedure for glutathione peroxidase (EC 1-11-1-9-) in blood
34. Measurement of catalase activity in tissue extracts
35. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
36. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
37. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity
38. Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals
39. Luciferase reporter gene cassettes for plant gene expression studies
40. Protective effects of antioxidants against UVA-induced DNA damage in human skin fibroblasts in culture
41. Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression
42. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc
43. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
44. ZnT-3, a putative transporter of zinc into synaptic vesicles
45. A novel gene involved in zinc transport is deficient in the lethal milk mouse
46. Functional expression of the human hZIP2 zinc transporter
47. Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone
48. Uptake and intracellular distribution of labile and total Zn(II) in C6 rat glioma cells investigated with fluorescent probes and atomic absorption
49. Separate pathways for cellular uptake of ferric and ferrous iron
50. Physiologic concentrations of zinc affect the kinetics of copper uptake and transport in the human intestinal cell model, Caco-2
51. Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network
52. Zinc-ligand interactions and oxygen free radicals formation
53. The antioxidant properties of zinc
54. Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells
55. In vitro inhibition of superoxide anion production and superoxide dismutase activity by zinc in human spermatozoa
56. On the use of Zn2+ to discriminate endonucleases activated during apoptosis
57. Thiolate ligands in metallothionein confer redox activity on zinc clusters
58. 2 with sulfhydryl groups in HL-60 cells: Zinc-metallothionein and other sites
59. Effect of zinc supplementation on resistance of cultured human skin fibroblasts toward oxidant stress
60. The role of zinc in selective neuronal death after transient global cerebral ischemia
61. Zinc protects against ultraviolet A1-induced DNA damage and apoptosis in cultured human fibroblasts
62. Zinc(II) protects against metal-mediated free radical induced damage: Studies on single and double-strand DNA breakage
63. Protective role of zinc-metallothionein on DNA damage in vitro by ferric nitrilotriacetate (Fe-NTA) and ferric salts
64. 2 with cell iron by zinc-metallothionein
65. Zinc transport and metallothionein secretion in the intestinal human cell line CaCo-2
66. Control of zinc transfer between thionein, metallothionein, and zinc proteins
67. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles
68. Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange
69. Protective effect of metallothionein to ras DNA damage induced by hydrogen peroxide and ferric ion-nitrilotriacetic acid
70. Evidence that nitric oxide enhances cadmium toxicity by displacing the metal from metallothionein
71. The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase
72. Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide
73. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes