Protective role of zinc-metallothionein on DNA damage in vitro by ferric nitrilotriacetate (Fe-NTA) and ferric salts

Chemico-Biological Interactions

Volumn 115, Issue 2, 1998, Pages 141-151

  Cai, Lu ^a   Tsiapalis, Gina ^a   Cherian, M Geroge ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Iron complexes; Metallothionein; Oxidative DNA damage; Transitional metals

Indexed keywords

HYDROXYL RADICAL; IRON COMPLEX; IRON SALT; METALLOTHIONEIN; NITRILOTRIACETATE IRON; ZINC;

ARTICLE; CELL PROTECTION; DNA DAMAGE; FLUORESCENCE; IN VITRO STUDY; KIDNEY TUMOR; NONHUMAN; OXIDATION;

ANIMALS; ANTIOXIDANTS; CATTLE; DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FERRIC COMPOUNDS; GLUTATHIONE; METALLOTHIONEIN; MUTAGENS; NITRILOTRIACETIC ACID; OXIDATIVE STRESS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMUS GLAND;

EID: 0031712266     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(98)00069-6     Document Type: Article

References (38)

1. S. Toyokuni, Iron-induced carcinogenesis: The role of redox regulation, Free Radic. Biol. Med. 20 (1996) 553-566.
2. P. Jenner, C.W. Olanow, Oxidative stress and the pathogenesis of Parkinson's disease, Neurology 47 (1996) 161-170.
3. M.A. Smith, P.L.R. Harris, L.M. Sayre, G. Perry, Iron accumulation in Alzheimer disease is a source of redox-generated from radicals, Proc. Natl. Acad. Sci. USA 94 (1997) 9866-9868.
4. M.G. Cherian, The significance of the nuclear and cytoplasmic location of metallothionein in human liver and tumor cells, Environ. Health Perspect. 102 (1994) 131-133.
5. M. Sato, I. Bremner, Oxygen free radicals and metallothionein, Free Radic. Biol. Med. 14 (1993) 325-337.
6. L. Cai, J. Koropatnick, M.G. Cherian, Metallothionein protects DNA from copper-induced, but not iron-induced cleavage in vitro, Chem.-Biol. Interact. 96 (1995) 143-155.
7. L. Cai, M.G. Cherian, Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: Effect of pre-exposure to zinc, and copper, Mutat. Res. 369 (1996) 233-241.
8. R. Meneghini, Iron homeostasis, oxidative stress and DNA damage, Free Radic. Biol. Med. 23 (1997) 783-792.
9. J. Abel, N. de Reuiter, Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein, Toxicol. Lett. 47 (1989) 191-196.
10. J.L. Li, S. Okada, S. Hamazaki, Y. Ebina, O. Midorikawa, Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate, Cancer Res. 47 (1987) 1867-1868.
11. S. Toyokuni, J.L. Sagripanti, DNA single- and double-strand breaks produced by ferric nitrilotriacetate in relation to renal tubular carcinogenesis, Carcinogenesis 14 (1993) 223-227.
12. Y. Ebina, S. Okada, S. Hamazaki, F. Ogino, J.I. Li, O. Midorikawa, Nephrotoxicity and renal cell carcinoma after use of iron- and aluminium-nitrilotriacetate complexes in rats, J. Natl. Cancer Inst. 76 (1986) 107-113.
13. G.R. Buettner, Ascorbate autoxidation in the presence of iron and copper chelates, Free Radic. Res. Commun. 1 (1986) 349-353.
14. L. Miline, P. Nicotera, S. Orrenius, M.J. Burkitt, Effect of glutathione and chelating agents on copper-mediated DNA oxidation: Pro-oxidant and antioxidant properties of glutathione, Arch. Biochem. Biophys. 304 (1993) 102-109.
15. G.F. Stephenson, H.M. Chan, M.G. Cherian, Copper-metallothionein from the toxic milk mutant mouse enhances lipid peroxidation initiated by an organic hydroperoxide, Toxicol. Appl. Pharmacol. 125 (1994) 90-96.
16. R. Stoewe, W.A. Prutz, Copper-catalyzed DNA damage by ascorbate and hydrogen peroxide: Kinetics and yield, Free Radic. Biol. Med. 3 (1987) 97-105.
17. S. Inoue, S. Kawanishi, Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide, Cancer Res. 47 (1987) 6522-6527.
18. S. Toyokuni, T. Mori, M. Dizdaroglu, DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate, Int. J. Cancer 57 (1994) 123-128.
19. T. Umemura, K. Sai, A. Takagi, R. Hasegawa, Y. Kurokawa, Formation of 8-hydroxydeoxyguanosine in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate, Carcinogenesis 11 (1990) 345-347.
20. A. Hartwig, H. Klyszcz-Nasko, R. Schlepegrell, D. Beyersmann, Cellular damage by ferric nitrilotriacetate and ferric citrate in V79 cells: Interrelationship between lipid peroxidation, DNA strand breaks and sister chromatid exchanges, Carcinogenesis 14 (1993) 107-112.
21. M.A. Schwarz, J.S. Lazo, J.C. Yalowich, I. Reynolds, V.E. Kagan, V. Tyurin, Y.-M. Kim, S.C. Watkins, B.R. Pitt, Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity, J. Biol. Chem. 269 (1994) 15238-15243.
22. M.G. Cherian, P. Ferguson, Metallothionein in cytotoxicity and genotoxiciy of metals, in: N.D. Hadjiliadis (Ed.), Cytotoxic, Mutatgenic and Carcinogenic Potential of Heavy Metals Related to Human Environment, NATO ASI series, 2. Environment, vol. 26, Kluwer, Dordrecht, 1997, pp. 217-230.
23. X.H. Du, C.Y. Yang, Mechanism of gentamicin nephrotoxicity in rats and the protective effect of zinc-induced metallothionein synthesis, Nephrol. Dial. Transplant. 9 (1994) 135-140.
24. M. Satoh, Y. Aoki, C. Tohyama, Protective role of metallothionein in renal toxicity of cisplatinum, Cancer Chemther. Pharmacol. 40 (1997) 358-362.
25. C.D. Klaassen, J. Liu, Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity, Drug Metab. Rev. 29 (1997) 79-102.
26. T.P. Coogan, R.M. Bare, M.P. Waalkes, Cadmium-induced DNA strand damage in cultured liver cells: Reduction in cadmium genotoxicity following zinc pretreatment, Toxicol. Appl. Pharmacol. 113 (1992) 227-233.
27. T.P. Coogan, R.M. Bare, E.J. Bjornson, W.P. Waalkes, Enhanced metallothionein gene expression is associated with protection from cadmium-induced genotoxicity in cultured rat liver cells, J. Toxicol. Environ. Health 41 (1994) 233-245.
28. L.S. Chubatsu, R. Menechini, Metallothionein protects DNA from oxidative damage, Bichem. J. 291 (1993) 193-198.
29. E.I. Goncharova, T.G. Rossman, A role for metallothionein and zinc in spontaneous mutagenesis, Cancer Res. 54 (1994) 5318-5323.
30. E.I. Goncharova, T.G. Rossman, The antimutagenic effects of metallothionein may involve free radical scavenging, in: B. Sarkar (Ed.), Genetic Response to Metals, Marcel Dekker, New York, 1995, pp. 87-100.
31. T.G. Rossman, E.I. Goncharova, A. Nadas, N. Dolzhanskaya, Chinese hamster cells expressing antisense to metallothionein become spontaneous mutators, Mutat. Res. 373 (1997) 75-85.
32. O. Kagimoto, A. Naganuma, N. Imura, T. Toge, O. Niwa, K. Yokoro, Effect of the administration of bismuth on radiogenic thymoma induction in mice, J. Radiat. Res. 32 (1991) 417-428.
33. M. Satoh, Y. Kondo, M. Mita, I. Nakagawa, A. Naganuma, N. Imura, Prevention of carcinogenicity of anticancer drugs by metallothionein induction, Cancer Res. 53 (1993) 4768-4769.
34. D. Banerjee, S. Onosaka, M.G. Cherian, Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney, Toxicology 24 (1982) 95-105.
35. M. Panemangalore, D. Banerjee, S. Onosaka, M.G. Cherian, Changes in intracellualar accumulation and distribution of metallothionein in rat liver and kidney during postnatal development, Dev. Biol. 97 (1983) 95-102.
36. N.O. Nartey, D. Banergee, M.G. Cherian, Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development, Pathology 19 (1987) 233-238.
37. M.G. Cherian, J.C. Lau, M.D. Apostolova, L. Cai, The nuclear-cytoplasmic presence of metallothionein in cells during differention and development, in: C.D. Klaassen (Ed.), MT-97, Birkhauser, Basel, 1998 (in press).
38. H. Haile Meskel, M.G. Cherian, V.J. Martinez, L.A. Veinot, J.V. Frei, Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry, Mod. Pathol. 6 (1993) 755-760.