Regulation of IFN-γ signaling is essential for the cytotoxic activity of CD8+ T cells

Journal of Immunology

Volumn 167, Issue 10, 2001, Pages 5574-5582

  Tau, G Z ^a   Cowan, S N ^a   Weisburg, J ^a   Braunstein, N S ^a   Rothman, P B ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GRANZYME B; PERFORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; IMMUNOSTIMULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TARGET CELL; TH1 CELL;

EID: 0035889927     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.10.5574     Document Type: Article

References (73)

1. + T cell effector mechanisms in resistance to infection
2. Roles of αβ and γδ T cell subsets in viral immunity
3. Tumor necrosis factor receptor and Fas signaling mechanisms
4. Interferon-γ: Biology and role in pathogenesis
5. Two ways to kill target cells
6. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
7. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
8. Induction of apoptosis in mature T cells by tumor necrosis factor
9. Cytokines induce the development of functionally heterogeneous T helper cell subsets
10. + T cells
11. + T cell responses: The alternative approaches
12. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
13. Dominance and crypticity of T cell antigenic determinants
14. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses
15. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes
16. + T lymphocyte differentiation as a mechanism for subdominant cytotoxic T lymphocyte responses to a viral antigen
17. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
18. Lymphocyte responses and cytokines
19. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
20. Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells
21. Ligand-induced autoregulation of IFN-γ receptor β chain expression in T helper cell subsets
22. Interferon γ signaling alters the function of T helper type 1 cells
23. Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice
24. Production of T cell clones
25. Proliferative assays for T cell function
26. The response of γ interferon activation factor is under developmental control in cells of the macrophage lineage
27. γ Chain-associated cytokine receptors signal through distinct transducing factors
28. Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors
29. Tyrosine phosphorylated p91 binds to a single element in the 1SGF/IRF-1 promoter to mediate induction by IFNα and IFNγ and is likely to autoregulate the p91 gene
30. A novel member of the interferon receptor family complements functionality of the murine interferon-γ receptor in human cells
31. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor
32. SOCS-1 is a potent inhibitor of IL-4 signal transduction
33. Induction and measurement of cytotoxic T lymphocyte activity
34. Determination of lymphocyte division by flow cytometry
35. How cells respond to interferons
36. Cellular responses to interferon-γ
37. Biologic functions of the IFN-γ receptors
38. Immune response in mice that lack the interferon-γ receptor
39. A simple method for evaluating the rejection of grafted spleen cells by flow cytometry and tracing adoptively transferred cells by light microscopy
40. A Janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons
41. A family of cytokine-inducible inhibitors of signalling
42. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in MI leukemia cells
43. Human lymphocyte response to phytomitogens in vitro: Normal, agammaglobulinemic and paraproteinemic individuals
44. The IFNγ receptor: A paradigm for cytokine receptor signaling
45. + T cells
46. + cytotoxic T lymphocyte effector function by Staphylococcus enterotoxin B
47. Peptide modification of blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production
48. + T cells by self-derived peptides
49. + T cells produce antiviral cytokines but are impaired in cytolytic function
50. Phosphatidylinositol 3-kinase-dependent and -independent cytolytic effector functions
51. Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity
52. 2+ signaling modulates cytolytic T lymphocyte effector functions
53. + T lymphocyte clones
54. IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity in vivo
55. Sensitivity of S49.1 cells to anti-CD95 (Fas/Apo-1)-induced apoptosis: Effects of CD95. Bcl-2 or Bcl-x transduction
56. Quantitative assay for lectin-induced cytoagglutination by means of an electronic particle-counting technique
57. The lectin concanavalin A stimulates a protein-tyrosine kinase p72syk in peripheral blood lymphocytes
58. Tyrosine phosphorylation is an obligatory event in IL-2 secretion
59. Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells
60. Role of a pertussis toxin substrate in the control of lectin-induced cap formation in human neutrophils
61. Early calcium signaling and calcium requirements for the IL-2 receptor expression and IL-2 production in stimulated lymphocytes
62. IL-10 attenuates IFN-αactivated STAT1 in the liver: Involvement of SOCS2 and SOCS3
63. Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
64. The suppressor of cytokine signaling (SOCS) I and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
65. Antiviral defense in mice lacking both α/β and γ interferon receptors
66. Two roads diverged: Interferon α/β- and interleukin 12-mediated pathways in promoting T cell interferon γ responses during viral infection
67. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
68. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ
69. T cell functions in granulocyte/macrophage colony-stimulating factor deficient mice
70. A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo
71. SOCS-1 can suppress CD3ζ- and Syk-mediated NF-AT activation in a non-lymphoid cell line
72. Characterization and use of monoclonal and polyclonal antibodies against the mouse interferon-γ receptor