Phosphatidylinositol 3-kinase-dependent and -independent cytolytic effector functions

Journal of Immunology

Volumn 162, Issue 11, 1999, Pages 6337-6340

  Fuller, Claudette L ^a,b   Ravichandran, Kodimangalam S ^a,b   Braciale, Vivian L ^a,b,c  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; SERINE PROTEINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CYTOLYSIS; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ANTIGENS, CD95; ANTIGENS, VIRAL; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; ENZYME INHIBITORS; FAS LIGAND PROTEIN; INFLUENZA A VIRUS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033152687     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Walsh, C., A. Glass, V. Chiu, and W. Clark. 1994. The role of the Fas lytic pathway in a perforin-less CTL hybridoma. J. Immunol. 153:2506.
2. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195.
3. Henkart, P. A. 1994. Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules. Immunity 1:343.
4. Liu, C. C., C. M. Walsh, and J. D. Young. 1995. Perform: structure and function. Immunol. Today 16:194.
5. Smyth, M. J., and S. A. Trapani. 1995. Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol. Today 16:202.
6. Vignaux, F., E. Vivier, B. Malissen, V. Depraetere, S. Nagata, and P. Golstein. 1995. TCR/CD3 coupling to Fas-based cytotoxicity. J. Exp. Med. 181:781.
7. Esser, M. T., B. Krishnamurthy, and V. L. Braciale. 1996. Distinct T cell receptor signaling requirements for perform-or FasL-mediated cytotoxicity. J. Exp. Med. 183:1697.
8. + T cells by a self-derived peptide. Nature 378:295.
9. + CTL effector function by Staphylococcus enterotoxin B. J. Immunol. 161:5179.
10. Ward, S. G., C. H. June, and D. Olive. 1996. PI 3-kinase: a pivotal pathway in T-cell activation? Immunol. Today 17:187.
11. Reif, K., C. D. Nobes, G. Thomas, A. Hall, and D. A. Cantrell. 1996. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6:1445.
12. Carpenter, C. L., and L. C. Cantley. 1996. Phosphoinositide kinases. Curr. Opin. Cell Biol. 8:153.
13. + T cells. J. Immunol. 158:4688.
14. Exley, M., L. Varticovski, M. Peter, J. Sancho, and C. Terhorst. 1994. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor ζ chain is dependent on T cell activation. J. Biol. Chem. 269:15140.
15. lck. J. Biol. Chem. 269:19435.
16. + cytotoxic T lymphocyte clones. Eur. J. Immunol. 25:3381.
17. Yano, H., S. Nakanishi, K. Kimura, N. Hanai, Y. Saitoh, Y. Fukui, Y. Nonomura, and Y. Matsuda. 1993. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268:25846.
18. Matzinger, P. 1991. The JAM test: a simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145:185.
19. Kayagaki, N., N. Yamaguchi, F. Nagao, S. Matsuo, H. Maeda, K. Okumura, and H. Yagita. 1997. Polymorphism of murine Fas ligand that affects the biological activity. Proc. Natl. Acad. Sci. USA 94:3914.
20. 2+ signaling modulates cytolytic T lymphocyte effector functions. J. Exp. Med. 187:1057.
21. Braciale, T. J., M. E. Andrew, and V. L. Braciale. 1981. Heterogeneity and specificity of cloned lines of influenza-virus specific cytotoxic T lymphocytes. J. Exp. Med. 153:910.
22. Woscholski, R., T. Kodaki, M. McKinnon, M. D. Waterfield, and P. J. Parker. 1994. A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase. FEBS Lett. 342:109.
23. Nakanishi, S., K. J. Catt, and T. Balla. 1995. A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids. Proc. Natl. Acad. Sci. USA 92:5317.
24. Cross, M. J., A. Stewart, M. N. Hodgkin, D. J. Kerr, and M. J. Wakelam. 1995. Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells: wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 270:25352.
25. Nakanishi, S., S. Kakita, I. Takahashi, K. Kawahara, E. Tsukuda, T. Sano, K. Yamada, M. Yoshida, H. Kase, Y. Matsuda, et al. 1992. Wortmannin, a microbial product inhibitor of myosin light chain kinase. J. Biol. Chem. 267:2157.
26. Kitani, S., R. Teshima, Y. Morita, K. Ito, Y. Matsuda, and Y. Nonomura. 1992. Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors. Biochem. Biophys. Res. Commun. 183:48.
27. lck tyrosine kinase. Eur. J. Immunol. 24:234.
28. Stowers, L., D. Yelon, L. J. Berg, and J. Chant. 1995. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 92:5027.
29. Marquardt, D. L., J. L. Alongi, and L. L. Walker. 1996. The phosphatidylinositol 3-kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production. J. Immunol. 156:1942.
30. syk and phosphatidylinositol 3-kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3.3. J. Immunol. 159:1200.
31. Teng, J. M., X. R. Liu, G. B. Mills, and B. Dupont. 1996. CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C. J. Immunol. 156:3222.
32. 2+ induced in CTLs by cellular antigen. J. Immunol. 141:2424.