Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans

Experimental Dermatology

Volumn 7, Issue 5, 1998, Pages 249-267

  Panteleyev, A A ^a   Paus, R ^b   Ahmad, W ^a   Sundberg, J P ^c   Christiano, A M ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c JACKSON LABORATORY   (United States)

Author keywords

Alopecia; Atrichia; Hair follicle; Hairless

Indexed keywords

ALOPECIA; CELL SPECIFICITY; GENE MUTATION; GENE STRUCTURE; HAIR FOLLICLE; HISTOPATHOLOGY; HUMAN; IMMUNOPATHOGENESIS; NONHUMAN; NUDE MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

EID: 0031763056     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0625.1998.tb00295.x-i1     Document Type: Review

References (138)

1. Montagna W, Chase H B, Melaragno H P. The skin of hairless mice. I. The formation of cysts and the distribution of lipids. J Invest Dermatol 1952: 19: 83-94.
2. Brooke H C. Hairless mice. J Hered 1926: 17: 173-174.
3. Howard A. "Rhino", an allele of hairless in the mouse. J Hered 1940: 31: 467-470.
4. Kligman L H. The hairless mouse model for photoaging. Clin Dermatol 1996: 14: 183-195.
5. Davies R E, Austin W A, Logani M K. The rhino mutant mouse as an experimental tool. Trans NY Acad Sci (Series II) 1971: 33: 680-693.
6. Poland A, Knutson J C. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 1982: 22: 517-554.
7. Sundberg J P, Beamer W G, Shultz L D, Dunstan R W. Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses. J Invest Dermatol 1990: 95: 62S-65S.
8. Cachon-Gonzalez M B, Fenner S, Coffin J M, Moran C, Best S, Stoye J P. Structure and expression of the hairless gene of mice. Proc Natl Acad Sci USA 1994: 91: 7717-7721.
9. Thompson C C. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. J Neurosci 1996: 16: 7832-7840.
10. Morrissey P J, Parcinson D R, Schwartz R S, Waksal S D. Immunologic abnormalities in HRS/J mice. I. Specific deficit in T lymphocyte helper function in a mutant mouse. J Immunol 1980: 125: 1558-1566.
11. Ignatieva E L, Malashenko A M, Blandova Z K. Morphofunctional characteristic of reproductive system in females of mutant B10-hrrhY mice strain. Bull Exp Biol Med 1988: 11: 602-603.
12. Meier H, Myers D D, Huebner R J. Genetic control by the hr-locus of susceptibility and resistance to leukemia. Proc Natl Acad Sci USA 1969: 63: 759-766.
13. Puhvel S M, Sacamoto M, Ertl D C, Reisner R M. Hairless mice as models for chloracne: A study of cutaneous changes induced by topical application of established chloracnegenes. Toxicol Appl Pharmacol 1982: 64: 492-503.
14. Myant N B. The role of the endocrine glands in mammalian brain development. In: Paoleti R, Davidson A N, eds. Chemistry and brain development. New York: Plenum, 1971: 227-237.
15. Shepard A R, Eberhardt N L. Molecular mechanisms of thyroid hormone action. Clin Lab Med 1993: 13: 531-541.
16. Ahmad W, ul Haque M F, Brancolini V et al. Alopecia universalis associated with a mutation in the human hairless gene. Science 1998: 279: 720-724.
17. Sundberg J P, Dunstan R W, Compton J G. Hairless mouse, HRS/J hr/hr. In: Jones T C, Mohr U, Hunt R D, eds. Monographs on Pathology of Laboratory Animals. Integument and Mammary Glands. Heidelberg: Springer-Verlag, 1989: 192-197.
18. Ahmad W, Irvine A, Lam H M et al. A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish Travelers. Am J Hum Genet (in press).
19. David L T. Studies on the expression of genetic hairlessness in the house mouse (Mus musculus). J Exp Zool 1934: 68: 501-518.
20. Kozak M. An analysis of 5′ noncoding sequences from 699 vertebrate messenger RNAs. Nucl Acids Res 1987: 15: 8125-8148.
21. Hoog C, Schalling M, Grunder-Brundell E, Daneholt B. Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein. Mol Reprod Dev 1991: 30: 173-181.
22. Thompson C C, Bottcher M C. The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proc Natl Acad Sci USA 1997: 94: 8527-8532.
23. Tsuji S, Yosida T. Reciprocal skin transplantation between normal and hereditary hairless mice. Jap J Genet 1965: 40: 50-62.
24. Billingham R E, Silvers W K. Transplantation and cutaneous genetics. J Invest Dermatol 1973: 60: 509-515.
25. Chase H B. Growth of the hair. Physiol Rev 1954: 34: 113-126.
26. Hardy M H, Vielkind U. Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 1. Follicle morphogenesis in wild-type mice. Acta Anat Basel 1996: 157: 169-182.
27. Paus R, Foitzik K, Welker P, Bulfone-Paus S, Eichmüller S. Transforming growth factor-beta receptor type I and type II expression during murine hair follicle development and cycling. J Invest Dermatol 1997: 109: 518-526.
28. Gilbert S F. Developmental biology. Sunderland, MS: Sinauer Associates, Inc., 1997: 918.
29. Summer F B. Hairless mice. J Hered 1924: 15: 475.
30. Snell G D. Inheritance in the house mouse, the linkage relations of short-ear, hairless, and naked. Genetics 1931: 16: 42-74.
31. Kligman L H, Kligman A M. The skin of the rhino mouse. In: Jones T C, Mohr U, Hunt R D, eds. Integument and mammary glands. Heidelberg, Germany. Springer-Verlag, 1989.
32. Mann S J. Varieties of hairless-like mutant mice. J Invest Dermatol 1971: 56: 170-173.
33. rh) mutations, chromosome 14. In: Sundberg J P, ed. Handbook of mouse mutations with skin and hair abnormalities. Boca Raton: CRC Press, 1994: 291-312.
34. Garber E D. Bald, a second allele of hairless in the house mouse. J Hered 1952: 43: 45-46.
35. Stelzner K F. Four dominant autosomal mutation affecting skin and hair development in the mouse. J Hered 1983: 74: 193-196.
36. rhY mice. Immunology 1984: 3: 25-28.
37. Jones J M, Elder J T, Simin K, Keller S A, Meisler M H. Insertional mutation of the hairless locus on mouse chromosome 14. Mamm Genome 1993: 4: 639-643.
38. rh9J): a new allele at the hairless locus. Vet Pathol 1998: 35: 297-299.
39. Stoye J P, Fenner S, Greenoak G E, Moran C, Coffin J M. Role of endogenous retroviruses as mutagens: the hairless mutation of mice. Cell 1988: 54: 383-391.
40. Coffin J M. Endogenous retroviruses. In: Weiss R, Teich N, Varmus H E, Coffin J M, eds. Molecular biology of tumor viruses, Part III. RNA tumor viruses, Vol 1, 2nd Edition. New York: Cold Spring Harbor: 1982: 1109-1203.
41. rh8J) phenotype: a nonsense mutation in the mouse hairless gene. Genomics (in press).
42. rhChr) phenotype: a nonsense mutation in the mouse hairless gene. Exp Dermatol 1998: 7: 298-301.
43. Green M C. Catalog of mutant genes and polymorphic loci. In: Lyon M F, Searle A G, eds. Genetic variants and strains of the laboratory mouse. Oxford: Oxford University Press, 1989: 12.
44. Johnson T M, Rosenberg M P, Meisler M H. An insulin-responsive element in the pancreatic enhancer of the amylase gene. J Biol Chem 1993: 268: 464-468.
45. Mann S J. Hair loss and cyst formation in hairless and rhino mutant mice. Anat Rec 1971: 170: 485-500.
46. rhY) phenotype: severe skin abnormalities and female reproductive defects associated with an insertion in the hairless gene. Exp Dermatol 1998: 7: 281-288.
47. Damste J, Prakken, J R. Atrichia with papular lesions: A variant of congenital ectodermal dysplasia, Dermatologica 1954: 108: 114.
48. Loewenthal L J A, Prakken J R. Atrichia with papular lesions, Dermatologica 1961: 22: 85.
49. Del Castilo V, Ruiz-Maldonado R, Carnevale A. Atrichia with papular lesions and mental retardation in two sisters. Int J Dermatol 1974: 13: 261-265.
50. Kanzler M H, Rasmussen J E. Atrichia with papular lesions. Arch Dermatol 1986: 122: 565-567.
51. Misciali C, Tosti A, Fanti P A, Borrello P, Piraccini B M. Atrichia and papular lesions: report of a case. Dermatol 1992: 185: 284.
52. Dawber R. Diseases of the hair and scalp. Oxford: Blackwell, 1997: 3rd Edition pp. 1-606.
53. Ahmad M, Abbas H, ul Haque S. Alopecia universalis as a single abnormality in an inbred Pakistani kindred. Am J Med Genet 1993: 46: 369-371.
54. Nothen M M, Cichon S, Vogt I R et al. A gene for autosomal congenital alopecia maps to chromosome 8p21-22. Am J Hum Genet 1998: 62: 386-390.
55. Paus R, Slominski A, Czarnetzki B M. Alopecia areata: an autoimmune response against melanogenesis-related proteins exposed by abnormal MHC class I expression in the proximal anagen hair bulb? Yale J Biol Med 1994: 66: 541-554.
56. Beletskaya L V, Belyaev D L, Blandova Z K, Malashenko A M, Bukhova V P, Shmidt E F. Elective detection of thymus epithelium and estimation of its functional and morphological involution in mice. Biologicheskie nauki 1984: 2: 108-112.
57. Mann S J, Straile WE. New observations on hair loss in the hairless mouse. Anat Rec 1961: 140: 97-101.
58. Ibrahim L, Wright E A. The growth of rats and mice vibrissae under normal and some abnormal conditions. J Embryol Exp Morphol 1975: 33: 831-844.
59. rh) mouse. Invest Ophthalmol Vis Sci 1988: 29: 1190-1194.
60. Yoshida M, Amemiya T, Yoshida H, Kawaji H. Cornea of rhino mouse: A model of corneal dystrophy. In: Silverstein A M, Oconnor G R, eds. 2nd International Symposium on Immunology and Immunopathology of the Eye. New York and Paris: Masson, 1978: 355.
61. Kligman L H, Kligman A M. The effect on rhino mouse skin of agents which influence keratinization and exfoliation. J Invest Dermatol 1979: 73: 354-358.
62. Bernerd F, Schweizer J, Demarchez M. Dermal cysts of the rhino mouse develop into unopened sebaceous glands. Arch Dermatol Res 1996: 288: 586-595.
63. Zheng P, Gendimenico G J, Mezick J A, Kligman A M. Topical all-trans retinoic acid rapidly corrects the folicular abnormalities of the rhino mouse. An ultrastructural study. Acta Derm Venereol 1993: 73: 97-101.
64. Panteleyev A A, van der Veen C, Rosenbach T Müller-Röver S, Sokolov V E, Paus R. Towards defining the pathogenesis of the hairless phenotype. J Invest Dermatol 1998: 110: 902-907.
65. Cotsarelis G, Sun T T, Lavker R M. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 1990: 61: 1329-1337.
66. Botchkarev V A, Eichmüller S, Johansson O, Paus R. Hair cycle-dependent plasticity of skin and hair follicle innervation in normal murine skin. J Comp Neurol 1997: 386: 379-395.
67. Paus R. Control of the hair cycle and hair diseases as cycling disorders. Curr Opin Dermatol 1996: 3: 248-258.
68. Stenn K S, Combates N J, Eilertsen K J et al. Hair follicle growth controls. Dermatol Clin 1996: 14: 543-558.
69. Jahoda C A, Horne K A, Oliver R F. Induction of hair growth by implantation of cultured dermal papilla cells. Nature 1984: 311: 560-562.
70. Raff M C, Barres B A, Burne J F, Coles H S, Ishizaki Y, Jacobson M D. Programmed cell death and the control of cell survival: lessons from the nervous system. Science 1993: 262: 695-700.
71. Montagna W, Chase H B, Brown P J. The skin of hairless mice. II. Ageing changes and the action of 20-methylcholanthrene. J Invest Dermatol 1954: 23: 259-269.
72. Panteleyev A A, Paus R, Wanner R et al. Keratin 17 gene expression during the murine hair cycle. J Invest Dermatol 1997: 108: 324-329.
73. Crew F A E, Mirskaia L. The character "hairless" in the mouse. J Genet 1931: 25: 17-24.
74. Gates A H, Arundell F D, Karasek M A. Hereditary defect of the pilosebaceous unit in a new double mutant mouse. J Invest Dermatol 1969: 52: 115-118.
75. Chuong C M, Chen H M, Jiang T X, Chia J. Adhesion molecules in skin development: morphogenesis of feather and hair. Ann N Y Acad Sci 1991: 642: 263-280.
76. Müller-Röver S, Paus R. Topobiology of the hair follicle: adhesion molecules as morphoregulatory signals during hair follicle morphogenesis. In: Chuong C-M, ed. Molecular biology of skin appendages morphogenesis. Austin TX: Landes Bioscience Publ. (in press).
77. Holland D B, Roberts S G, Cunliffe WJ. Localisation of keratin 17 mRNA in acne. J Invest Dermatol 1997: 108: 384.
78. Pinkus H. Multiple hairs (Flemming-Giovannini). J Invest Dermatol 1951: 17: 291-301.
79. Fraser F C. The expression and interaction of hereditary factors producing hypotrichosis in the mouse: histology and experimental results. Canad J Res 1946: 24D: 10-25.
80. Lindner G, Botchkarev V A, Botchkareva N V, Ling G, van der Veen C, Paus R. Analysis of apoptosis during hair follicle regression. Am J Pathol 1997: 151: 1601-1617.
81. Pinkus H, Iwasaki T, Mishima Y. Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization. J Anat 1981: 133: 19-35.
82. Panteleyev A A, Botchkareva N V, van der Veen C, Christiano A M, Paus R. Pathobiology of the hairless phenotype: Dysregulation of hair follicle apoptosis and topobiology during the initiation of follicle cycling. J Invest Dermatol 1998b: 110: 577.
83. Weedon D, Strutton G. Apoptosis as the mechanism of the involution of hair follicles in catagen transformation. Acta Derm Venereol 1981: 61: 335-339.
84. Kaplan E D, Holbrook K A. Dynamic expression patterns of tenascin, proteoglycans, and cell adhesion molecules during human hair follicle morphogenesis. Dev Dyn 1994: 199: 141-155.
85. Tsubura A, Morii S, Ikehara S. Growth of the mammary gland in rhino mouse. Jikken Dobutsu 1993: 42: 639-642.
86. Topper Y J, Freeman C S. Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev 1980: 60: 1049-1106.
87. Philpott M, Paus R. Hair follicle morphogenesis. In: Chuong C M, ed., Molecular Biology of Epithelial Appendage Morphogenesis. Austin, TX: Landes Bioscience, 1998, in press.
88. Wooding F B P. Comparative mammary fine structure. London: Symp Zool Soc, 1977: 41: 1-41.
89. Stirling J W, Chandler J A. The fine structure of the normal resting, terminal ductal lobular unit of the female breast. Virchows Arch A 1976: 372: 205-226.
90. Garcia J E, Jones G S, Wright G L. Prediction of the time of ovulation. Fertil Steril 1981: 36: 308-315.
91. Hsueh A J, Eisenhauer K, Chun S Y Hsu S Y, Billig H. Gonadal cell apoptosis. Recent Prog Horm Res 1996: 51: 433-455.
92. Heiniger H J, Meier H, Kaliss N, Cherry M, Chen H W, Stoner RC. Hereditary immunodeficiency and leukemogenesis in HRS/J mice. Cancer Res 1974: 34: 201-211.
93. Heiniger H J, Huebner R J, Meier H. Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis. J Natl Cancer Inst 1976: 56: 1073-1074.
94. Johnson D A, Meier H. Immune responsiveness of HRS/J mice to syngeneic lymphoma cells. J Immunol 1981: 127: 461-464.
95. Tempelis L D. Leucemic transformation in HRS mice occurs in an immature-nonactivated thymocyte population. Cell Immunol 1984: 83: 142-151.
96. Takaoki M, Kawaji H. Impaired antibody response against T-dependent antigens in rhino mice. Immunology 1980: 40: 27-32.
97. Reske-Kunz A B, Scheild M P, Boyse E A. Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. J Exp Med 1979: 149: 228-233.
98. Archinal W A, Wilder M S. Susceptibility of HRS/J mice to listeriosis: macrophage activity. Infect Immun 1988: 56: 613-618.
99. Hiai H, Morrissey P, Khiroya R, Schwartz R S. Selective expression of xenotropic virus in congenic HRS/S (hairless) mice. Nature 1977: 270: 247-249.
100. Harris D T, LoCascio J, Acevedo A, Olson G B, Bard J, Boyse E A. Analysis of the hairless mouse as a model for the effects of aging on the immune system. Immunol Lett 1993: 36: 19-26.
101. Harnby D, Gowland G, Holland K T, Kearney J N. The cutaneous microbiology of haired and hairless mice. J Appl Bact 1990: 69: 686-691.
102. Sprecher E, Becker Y, Kraal G, Hall E, Shultz L D. Effect of genetically determined immunodeficiency on epidermal cell populations in C57BL/6J mice. Arch Dermatol Res 1990: 282: 188-193.
103. Kawaji H, Tsukuda R, Nakaguchi T. Immunopathology of rhino mouse, an autosomal recessive mutant with murine lupus-like disease. Acta Pathol Jpn 1980: 30: 515-530.
104. Roberts R D, Kier A B, Walker S E. The RHJ/Le rhino mutant: description of a unique murine model of autoimmunity. J Comp Pathol 1989: 100: 391-404.
105. Pottathil R, Meier H, Huebner R J. Suppression of leukemogenesis in hairless mice by antitype C viral gamma globulins. Naturwissenschaften 1978: 65: 443-444.
106. Heath V L, Saoudi A, Seddon B P, Moore N C, Fowell D J, Mason D W. The role of the thymus in the control of autoimmunity. J Autoimmun 1996: 9: 241-246.
107. Streilein J W. Skin-associated lymphoid tissues (SALT): origin and functions. J Invest Dermatol 80 (Suppl.) 1983: 6: 12S-16S.
108. Bos J D, ed. The skin immune system (SIS). 2nd ed., Boca Raton. FL: CRC Press, 1997.
109. Birnbaum L S. The mechanism of dioxin toxicity: relationship to risk assessment. Environ Health Perspect 1994: 102 (Suppl. 9): 157-167.
110. Crow K D. Chloracne. Trans St Johns Hosp Dermatol Soc 1970: 56: 77-99.
111. Taylor J S. Chloracne - a continuing problem. Cutis 1974: 13: 585-591.
112. Kimbrough RD. Morphology of lesions produced by the dioxins and related compounds. In: Tucker R E, Young A L, Gray A P, eds. Human and environmental risks of chlorinated dioxins and related compounds. New York: Plenum Press, 1983: 527-538.
113. Okey A B, Riddick D S, Harper P A. The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Toxicol Lett 1994: 70: 1-22.
114. Dolwick K M, Schmidt J V, Carver L A et al. Cloning and expression of a human Ah receptor cDNA. Mol Pharmacol 1993: 44: 911-917.
115. Whitlock J P. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu Rev Pharmacol Toxicol 1990: 30: 251-277.
116. Fernandez-Salguero P, Pineau T, Hubert D M et al. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 1995: 268: 722-726.
117. Wanner R, Brommer S, Czarnetzki B M, Rosenbach T. The differentiation-related upregulation of aryl hydrocarbon receptor transcript levels is suppressed by retinoic acid. Retinoic acid affects the expression rate of the differentiation-related genes aryl hydrocarbon receptor, ARNT and keratin 4 in proliferative keratinocytes only. Biochem Biophys Res Commun 1995: 209: 706-711.
118. Panteleyev A A, Wanner R, Nürnberg W, Henz B M, Rosenbach T. Dioxin-binding Ah-receptor expression in normal and psoriatic skin. Arch Derm Res 1996: 288: 288 (Abstr).
119. Nebert D W, Gielen J E. Genetic regulation of aryl hydrocarbons hydroxylase induction in the mouse. Fed Proc 1972: 31: 1315-1327.
120. Raunio H, Pelkonen O. Effect of polycyclic aromatic compounds and phorbol esters on ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in mouse liver. Cancer Res 1983: 43: 782-786.
121. Taylor B A. Strain distribution and linkage test of 7,12-dimethylbenzantracene (DMBA) inflammatory response in mice. Life Sciences 1971: 10: 1127-1134.
122. McConnell E E, Moore J A, Haseman J K, Harris M W. The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs. Toxicol Appl Pharmacol 1978: 44: 335-356.
123. Inagami K, Koga T, Kikuchi M, Hashimoto M, Takahashi H, Wada K. Experimental study of hairless mice following administration of rice oil used by a "Yusho" patient. Fukuoka Acta Med 1969: 60: 548-553.
124. Knutson J C, Poland A. Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: interaction of the Ah and hr loci. Cell 1982: 30: 225-234.
125. Poland A, Knutson J C, Glover E. Histologic changes produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the skin of mice carrying mutations that affect the integument. J Invest Dermatol 1984: 83: 454-459.
126. Panteleyev A A, Thiel R, Wanner R et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects the keratin 1 and keratin 17 gene expression and differentially induces keratinization in hairless mouse skin. J Invest Dermatol 1997b: 108: 330-335.
127. Abbott B D, Birnbaum L S. TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD. Toxicol Appl Pharmacol 1990: 106: 418-432.
128. Soler A P, Gilliard G, Megosh L C, O'Brien TG. Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity. J Invest Dermatol 1996: 106: 1108-1113.
129. Takigawa M, Verma A K, Simsiman R C, Boutwell R K. Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase, α-difluoromethylornithine. Biochem Biophys Res Commun 1982: 105: 969-976.
130. Weeks C F, Hermann A L, Nelson F R, Slaga T S. α-Difluoromethylornithine, an irreversible inhibitor of ornothine decarboxylase, inhibits promoter-induced polyamine accumulation and carcinogenesis in mouse skin. Proc Natl Acad Sci USA 1982: 79: 6028-6032.
131. Suskind R R. Chloracne, "the hallmark of dioxin intoxication". Scand J Work Environ Health 1985: 11: 165-171.
132. Mocarelli P, Marocchi A, Brambilla P, Gerthoux P, Young D S, Mantel N. Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy. JAMA 1986: 256: 2687-2695.
133. Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T. New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 1994: 372: 103-107.
134. Schüddekopf K, Schorpp M, Boehm T. The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain. Proc Natl Acad Sci USA 1996: 93: 9661-9664.
135. Stogdale L, Botha W S, Saunders G N. Congenital hypotrichosis in a dog. J Am Anim Hosp Assoc 1982: 18: 184-187.
136. Letard E. Hairless siamese cats. J Hered 1931: 29: 173-175.
137. Jayasekara M U, Leipold H W, Cook J E. Pathological changes in congenital hypotrichosis in Hereford cattle. Zentralbl Veterinarmed 1979: 26: 744-753.
138. Ratterree M S, Baskin G B. Congenital hypotrichosis in a rhesus monkey. Lab Anim Sci 1992: 42: 410-412.