MDR1 bicistronic vectors: Analysis of selection stringency, amplified gene expression, and vector stability in cell lines

Biochemical Pharmacology

Volumn 62, Issue 6, 2001, Pages 693-704

  Kane, Susan E ^a,b   Matsumoto, Linda ^a   Metz, Marianne Z ^a   Donohue, Cecile A ^a   Lingeman, Robert G ^a   Lin, Sharon W ^a   Doroshow, James H ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Tel: +1 626 301 8834 ^*  (United States)

Author keywords

Bicistronic retroviral vector; Chemotherapy; Gene therapy; Gene transfer; MDR1; Selection

Indexed keywords

ANTIBIOTIC G 418; COLCHICINE; GENE PRODUCT; MESSENGER RNA; PACLITAXEL; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL SURVIVAL; CHEMOTHERAPY; CONTROLLED STUDY; DNA VECTOR; EXPRESSION VECTOR; GENE AMPLIFICATION; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC SELECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MARKER GENE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; TISSUE CULTURE CELL;

3T3 CELLS; ANIMALS; CELL LINE; COLCHICINE; DRUG RESISTANCE; GENE AMPLIFICATION; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GENTAMICINS; HUMANS; K562 CELLS; MICE; NUCLEIC ACID AMPLIFICATION TECHNIQUES; P-GLYCOPROTEIN; RETROVIRIDAE; SELECTION (GENETICS);

EID: 0035885313     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00727-4     Document Type: Article

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