High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors

Blood

Volumn 88, Issue 9, 1996, Pages 3407-3415

  Eckert, Hans Georg ^b   Stockschläder, Marcus ^b   Just, Ursula ^b   Hegewisch Becker, Susanna ^b   Grez, Manuel ^b   Uhde, Almut ^b   Zander, Axel ^b   Ostertag, Wolfram ^b   Baum, Christopher ^a  

^a LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; CYTOSTATIC AGENT; PACLITAXEL; VIRUS VECTOR;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG MEGADOSE; GENETIC TRANSDUCTION; HARVEY SARCOMA ONCOVIRUS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOLONEY LEUKEMIA ONCOVIRUS; MULTIDRUG RESISTANCE; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; RETROVIRUS; SARCOMA VIRUS; SPLEEN FOCUS FORMING VIRUS;

EID: 0029909913     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.9.3407.bloodjournal8893407     Document Type: Article

References (38)

1. Friedmann T: Human gene therapy - an immature genie, but certainly out of the bottle. Nat Med 2:144, 1996
2. Leiden JM: Gene therapy - promise, pitfalls and prognosis. N Engl J Med 333:871, 1995
3. Kohn DB: The current status of gene therapy using hematopoietic stem cells. Curr Opin Pediatr 7:56, 1995
4. Baum C, Hegewisch-Becker S, Eckert H-G, Stocking C, Ostertag W: Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells. J Virol 69:7541, 1995
5. Baum C, Eckert H-G, Stocking C, Ostertag W: Activity of Friend mink cell focus-forming retroviruses during myelo-erythroid hematopoiesis. Exp Hematol 24:364, 1996
6. Correll PH, Colilla S, Karlsson S: Retroviral vector design for long-term expression in murine hematopoietic cells in vivo. Blood 84:1812, 1994
7. Riviere I, Brose K, Mulligan RC: Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells. Proc Natl Acad Sci USA 92:6733, 1995
8. Stocking C, Grez M, Ostertag W: Regulation of retrovirus infection and expression in embryonic and hematopoietic stem cells, in Doerfler W and Böhm P (eds): Virus Strategies. Molecular Biology and Pathogenesis. VCH Verlagsgesellschaft mbH, Weinheim, Germany, 1993 p 433
9. Grez M, Zornig M, Nowock J, Ziegler M: A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells. J Virol 65:4691, 1990
10. Grez M, Akgün E, Hilberg F, Ostertag W: Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells. Proc Natl Acad Sci USA 87:9202, 1990
11. Gottesman MM, Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385, 1993
12. Hanania EG, Fu S, Zu Z, Hegewisch-Becker S, Korbling M, Hester J, Durett A, Andreef M, Mechetner E, Holzmeyer T, Roninson IB, Giles RE, Berenson R, Heimfeld S, Deisseroth AB: Chemotherapy resistance to taxol in clonogenic progenitor cells following transduction of CD34 selected marrow and peripheral blood cells with a retrovirus that contains the MDR-1 chemotherapy resistance gene. Gene Ther 2:1, 1995
13. Bertolini F, de Monte L, Corsini C, Lazzari L, Lauri E, Soligo D, Ward M, Bank A, Malavasi F: Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells. Br J Haematol 88:318, 1994
14. DelaFlor-Weiss E, Richardson C, Ward M, Himelstein A, Smith L, Podda S, Gottesman M, Pastan I, Bank A: Transfer and expression of the human multidrug resistance gene in mouse erythro-leukemia cells. Blood 80:3106, 1992
15. Hanania EG, Deisseroth AB: Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model. Cancer Gene Ther 1:21, 1994
16. Hegewisch-Becker S, Hanania EG, Fu S, Korbling M, Deisseroth AB, Andreeff M: Transduction of MDK1 into human and mouse haemopoietic progenitor cells: Use of rhodamine (Rh123) to determine transduction frequency and in vivo selection. Br J Haematol 90:876, 1995
17. Podda S, Ward M, Himelstein A, Richardson C, DelaFlor-Weiss E, Smith L, Gottesman M, Pastan I, Bank A: Transfer and expression of the human multiple drug resistance gene into live mice. Proc Natl Acad Sci USA 89:9676, 1992
18. Licht T, Aksentijevich I, Gottesman MM, Pastan I: Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells. Blood 86:111, 1995
19. Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW: Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science 257:99, 1992
20. Sorrentino BP, McDonagh KT, Woods D, Orlic D: Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice. Blood 86:491, 1995
21. + cells. Blood 84:1408, 1994
22. Spooncer E, Boettiger D, Dexter TM: Isolation and culture of factor-dependent haemopoietic cell lines, in Testa NG, Molineux G (eds): Haemopoiesis. A Practical Approach. Oxford University Press, Oxford, UK, 1993, p 107
23. Beck-Engeser G, Stocking C, Just U, Albritton L, Dexter M, Spooncer E, Ostertag W: Retroviral vectors related to the myeloproliferative sarcoma virus allow efficient expression in hematopoietic stem and precursor cell lines, but retroviral infection is reduced in more primitive cells. Hum Gene Ther 2:61, 1991
24. Just U, Stocking C, Spooncer E, Dexter TM, Ostertag W: Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation. Cell 64:1163, 1991
25. Knaän-Shanzer S, Valerio D, van Beusechem VW: Cell cycle state, response to hemopoietic growth factors and retroviral vector-mediated transduction of human hemopoietic stem cells. Gene Ther 3:333, 1996
26. Sutherland HJ, Eaves AC, Eaves CJ: Quantitative assays for human hematopoietic progenitor cells, in Gee A (ed): Bone Marrow Processing and Purging: A Practical Guide. CRC, Boca Raton, FL, 1991, p 155
27. Robinson JP: Handbook of Flow Cytometry Methods. New York, NY, Wiley-Liss, 1993
28. Lichtenberg U, Quintrell N, Bishop JM: Human protein-tyrosinase kinase gene HCK: Expression and structural analysis of the promoter region. Oncogene 7:849, 1992
29. Huizing MT, Keung ACF, Rosing H, van-der-Kuij V, ten-Bokkel-Huinink WW, Mandjes IM, Dubbelman AC, Pinedo HM, Beijnen JH: Pharmakokinetics of paclitaxel and metabolites in a randomized comparative study in platinum pretreated ovarian cancer patients. J Clin Oncol 11:2127, 1993
30. Deisseroth AB, Kavanagh J, Champlin R: Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during therapy of ovarian cancer: A pilot trial. Hum Gene Ther 5:1507, 1994
31. O'Shaughnessy JA, Cowan KH, Nienhuis AW, McDonagh KT, Sorrentino BP, Dunbar CE, Chiang Y, Wilson W, Goldspiel B, Kohler D, Cottler-Fox M, Leitman S, Gottesman M, Pastan I, Denicoff A, Noone M, Gress R: Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer. Hum Gene Ther 5:891, 1994
32. Baum C, Margison GP, Eckert H-G, Fairbaim LJ, Ostertag W, Rafferty JA: Gene transfer to augment the therapeutic index of anticancer chemotherapy (editorial). Gene Ther 3:1, 1996
33. Aran JM, Gottesman MM, Pastan I: Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proc Natl Acad Sci USA 91:3176, 1994
34. Jelinék J, Fairbairn LJ, Dexter M, Rafferty JA, Stocking C, Ostertag W, Margison, GP: Long-term protection of hematopoiesis against the cytotoxic effects of multiple doses of nitrosoureas by retrovirus-mediated expression of human O6-alkylguanine-DNA-alkyltransferase. Blood 87:1957, 1996
35. Tumas DB, Spangrude GJ, Brooks DM, Williams CD, Chesebro B: High-frequency cell-surface expression of a foreign protein in murine hematopoietic stem cells using a new retroviral vector. Blood 87:509, 1996
36. Baum C, Eckert HG, Ostertag W: Contribution of the retroviral leader to gene transfer and expression in packaging cells and myeloid stem and progenitor cells, in Zander A, Ostertag W, Afanasiev BV, Grosveld F (eds): Gene Technology. NATO ASI Series, vol H 94. Springer-Verlag, Berlin, Heidelberg, 1996, p 219
37. Wells S, Malik P, Pensiero M, Kohn DB, Nolta JA: The presence of an autologous marrow stromal cell layer increases glucocerebrosidase gene transduction of long-term culture initiating cells (LTCICs) from the bone marrow of a patient with Gaucher disease. Gene Ther 2:512, 1995
38. Chuck AS, Palsson BO: Consistent and high rates of gene transfer can be obtained using flow-through transduction over a wide range of retroviral titers. Hum Gene Ther 7:743, 1996