A bicistronic retroviral vector for protecting hematopoietic cells against antifolates and P-glycoprotein effluxed drugs

Human Gene Therapy

Volumn 8, Issue 15, 1997, Pages 1773-1783

  Galipeau, Jacques ^a   Benaim, Ely ^b   Spencer, Harold T ^b   Blakley, Raymond L ^b   Sorrentino, Brian P ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DIHYDROFOLATE REDUCTASE; ETOPOSIDE; FOLIC ACID ANTAGONIST; GLYCOPROTEIN P; METHOTREXATE; PACLITAXEL; TRIMETREXATE; VINBLASTINE; VIRUS VECTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CELL PROTECTION; GENE TRANSFER; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PROMYELOCYTE; RETROVIRUS; T LYMPHOBLAST;

MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0030715345     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.15-1773     Document Type: Article

References (7)

1. ALLAY, J.A., DUMENCO, L.L., KOC, O.N., LIU, L., and GERSON, S.L. (1995). Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells. Blood 85, 3342-3351.
2. ALLEGRA, C.J., CHABNER, B.A., DRAKE, J.C., LUTZ, R., RODBARD, D., and JOLIVET, J. (1985a). Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J. Biol. Chem. 260, 9720-9726.
3. ALLEGRA, C.J., DRAKE, J.C., JOLIVET, J., and CHABNER, B.A. (1985b). Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proc. Natl. Acad. Sci. USA 82, 4881-4885.
4. ARAN, J.M., GOTTESMAN, M.M., and PASTAN, I. (1994). Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proc. Natl. Acad. Sci. USA 91, 3176-3180.
5. BANERJEE, D., ZHAO, S.C., LI, M.X., SCHWEITZER, B.I., MINEISHI, S., and BERTINO, J.R. (1994). Gene therapy utilizing drug resistance genes: a review. Stem Cells (Dayt) 12, 378-385.
6. BODINE, D.M., KARLSSON, S., and NIENHUIS, A.W. (1989). Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 86, 8897-8901.
7. ZHAO, S.C., LI, M.X., BANERJEE, D., SCHWEITZER, B.I., MINEISHI, S., GILBOA, E., and BERTINO, J.R. (1994). Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate reductase. Cancer Gene Ther. 1, 27-33.