Complete rescue of lethal albino c(14CoS) mice by null mutation of 4- hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway

Journal of Biological Chemistry

Volumn 272, Issue 39, 1997, Pages 24426-24432

  Endo, Fumio ^a   Kubo, Shuji ^a   Awata, Hisataka ^a   Kiwaki, Koji ^a   Katoh, Hideki ^c   Kanegae, Yumi ^d   Saito, Izumu ^d   Miyazaki, Jun Ichi ^e   Yamamoto, Tetsuro ^b   Jakobs, Cornelis ^f   Hattori, Shinzaburo ^a   Matsuda, Ichiro ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; FUMARYLACETOACETASE; TYROSINE;

AMINOACIDEMIA; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RISK; CATABOLISM; ENZYME DEFICIENCY; ENZYME INDUCTION; GENE MUTATION; HISTOLOGY; LIVER CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TYROSINEMIA;

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; ALLELES; AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; APOPTOSIS; LIVER; LIVER FUNCTION TESTS; MICE; MICE, MUTANT STRAINS; MUTATION; PHENOTYPE; TYROSINE;

ANIMALIA;

EID: 9844238697     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.39.24426     Document Type: Article

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