Glucagon-like Peptide (GLP)-2 Action in the Murine Central Nervous System is Enhanced by Elimination of GLP-1 Receptor Signaling

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21489-21499

  Lovshin, Julie ^a   Estall, Jennifer ^a   Yusta, Bernardo ^a   Brown, Theodore J ^b,c   Drucker, Daniel J ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GASTROENTEROLOGY; GENETIC ENGINEERING; NEUROLOGY;

PEPTIDES;

BIOCHEMISTRY;

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 2; GLUCAGON RECEPTOR; UNCLASSIFIED DRUG; BETA GALACTOSIDASE; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; MESSENGER RNA; PEPTIDE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DENTATE GYRUS; DNA LIBRARY; EPITHELIUM CELL; FOOD INTAKE; GASTROINTESTINAL TRACT; INTESTINE MUCOSA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RECEPTOR DOWN REGULATION; STOMACH ACID SECRETION; TISSUE SPECIFICITY; AMINO ACID SEQUENCE; AMYGDALOID NUCLEUS; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; BRAIN VENTRICLE; CELL LINE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; HYPOPHYSIS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

ANIMALIA; MURINAE;

AMINO ACID SEQUENCE; AMYGDALA; ANIMALS; BASE SEQUENCE; BETA-GALACTOSIDASE; BRAIN; CELL LINE; CEREBRAL VENTRICLES; GASTROINTESTINAL HORMONES; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE 2; HUMANS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PEPTIDES; PITUITARY GLAND; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCAGON; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0035877847     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009382200     Document Type: Article

References (67)

1. Mojsov, S., Heinrich, G., Wilson, I. B., Ravazzola, M., Orci, L., and Habener, J. F. (1986) J. Biol. Chem. 261, 11880-11889
2. Drucker, D. J. (1998) Diabetes 47, 159-169
3. Drucker, D. J. (2001) Endocrinology 142, 521-527
4. Holst, J. J. (1999) Trends Endocrinol. Metab. 10, 229-235
5. Kieffer, T. J., and Habener, J. F. (1999) Endocr. Rev. 20, 876-913
6. Xu, G., Stoffers, D. A., Habener, J. F., and Bonner-Weir, S. (1999) Diabetes 48, 2270-2276
7. Stoffers, D. A., Kieffer, T. J., Hussain, M. A., Drucker, D. J., Egan, J. M., Bonner-Weir, S., and Habener, J. F. (2000) Diabetes 49, 741-748
8. Drucker, D. J., Ehrlich, P., Asa, S. L., and Brubaker, P. L. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7911-7916
9. Tsai, C.-H., Hill, M., and Drucker, D. J. (1997) Am. J. Physiol. 272, G662-G668
10. Tsai, C.-H., Hill, M., Asa, S. L., Brubaker, P. L., and Drucker, D. J. (1997) Am. J. Physiol. 273, E77-E84
11. Wojdemann, M., Wettergren, A., Hartmann, B., and Holst, J. J. (1998) Scand. J. Gastroenterol. 33, 828-832
12. Wojdemann, M., Wettergren, A., Hartmann, B., Hilsted, L., and Holst, J. J. (1999) J. Clin. Endocrinol. Metab. 84, 2513-2517
13. Benjamin, M. A., McKay, D. M., Yang, P. C., Cameron, H., and Perdue, M. H. (2000) Gut 47, 112-119
14. Cheeseman, C. I., and Tsang, R. (1996) Am. J. Physiol. 271, G477-G482
15. Drucker, D. J., Yusta, B., Boushey, R. P., Deforest, L., and Brubaker, P. L. (1999) Am. J. Physiol. 276, G79-G91
16. Boushey, R. P., Yusta, B., and Drucker, D. J. (1999) Am. J. Physiol. 277, E937-E947
17. Alavi, K., Schwartz, M. Z., Palazzo, J. P., and Prasad, R. (2000) J. Pediatr. Surg. 35, 847-851
18. Prasad, R., Alavi, K., and Schwartz, M. Z. (2000) J. Pediatr. Surg. 35, 357-359
19. Drucker, D. J., and Asa, S. (1988) J. Biol. Chem. 263, 13475-13478
20. Han, V. K. M., Hynes, M. A., Jin, C., Towle, A. C., Lauder, J. M., and Lund, P. K. (1986) J. Neurosci. Res. 16, 97-107
21. Larsen, P. J., Tang-Christensen, M., Holst, J. J., and Orskov, C. (1997) Neuroscience 77, 257-270
22. Merchenthaler, I., Lane, M., and Shughrue, P. (1999) J. Comp. Neurol. 403, 261-280
23. Campos, R. V., Lee, Y. C., and Drucker, D. J. (1994) Endocrinology 134, 2156-2164
24. Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., Wilding, J. P. H., Smith, D. M., Ghatei, M. A., Herbert, J., and Bloom, S. R. (1996) Nature 379, 69-72
25. Beak, S. A., Heath, M. M., Small, C. J., Morgan, D. G. A., Ghatei, M. A., Taylor, A. D., Buckingham, J. C., Bloom, S. R., and Smith, D. M. (1998) J. Clin. Invest. 101, 1334-1341
26. Beak, S. A., Small, C. J., Ilovaiskaia, I., Hurley, J. D., Ghatei, M. A., Bloom, S. R., and Smith, D. M. (1996) Endocrinology 137, 4130-4138
27. Seeley, R. J., Blake, K., Rushing, P. A., Benoit, S., Eng, J., Woods, S. C., and D'Alessio, D. (2000) J. Neurosci. 20, 1616-1621
28. Seeley, R. J., Woods, S. C., and D'Alessio, D. (2000) Endocrinology 141, 473-475
29. Rinaman, L. (1999) Am. J. Physiol. 277, R582-R590
30. Toft-Nielsen, M. B., Madsbad, S., and Holst, J. J. (1999) Diabetes Care 22, 1137-1143
31. Szayna, M., Doyle, M. E., Betkey, J. A., Holloway, H. W., Spencer, R. G., Greig, N. H., and Egan, J. M. (2000) Endocrinology 141, 1936-1941
32. Hoosein, N. M., and Gurd, R. S. (1984) FEBS Lett. 178, 83-86
33. Munroe, D. G., Gupta, A. K., Kooshesh, P., Rizkalla, G., Wang, H., Demchyshyn, L., Yang, Z.-J., Kamboj, R. K., Chen, H., McCallum, K., Sumner-Smith, M., Drucker, D. J., and Crivici, A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1569-1573
34. Yusta, B., Huang, L., Munroe, D., Wolff, G., Fantaske, R., Sharma, S., Demchyshyn, L., Asa, S. L., and Drucker, D. J. (2000) Gastroenterology 119, 744-755
35. Tang-Christensen, M., Larsen, P. J., Thulesen, J., Romer, J., and Vrang, N. (2000) Nat. Med. 6, 802-807
36. Tang-Christensen, M., Larsen, P. J., Goke, R., Fink-Jensen, A., Jessop, D. S., Moller, M., and Sheikh, S. P. (1996) Am. J. Physiol. 271, R848-R856
37. White, R. B., Broqua, P., Meyer, J., Junien, J.-L., and Aubert, M. L. (2000) 82nd Annual Meeting of the Endocrine Society, June 21-24, Toronto, Ontario, Canada, p. 271, Abstr. 1115, The Endocrine Society Press, Bethesda, MD
38. Chomczynski, P., and Sacchi, N. (1987) Anal. Biochem. 162, 156-159
39. Piechaczyk, M., Blanchard, J. M., Marty, L., Dani, C., Panabieres, F., El Sabouty, S., Fort, P., and Jeanteur, P. (1984) Nucleic Acids Res. 12, 6951-6963
40. Drucker, D. J., Shi, Q., Crivici, A., Sumner-Smith, M., Tavares, W., Hill, M., Deforest, L., Cooper, S., and Brubaker, P. L. (1997) Nat. Biotechnol. 15, 673-677
41. DaCambra, M. P., Yusta, B., Sumner-Smith, M., Crivici, A., Drucker, D. J., and Brubaker, P. L. (2000) Biochemistry 39, 8888-8894
42. Yusta, B., Somwar, R., Wang, F., Munroe, D., Grinstein, S., Klip, A., and Drucker, D. J. (1999) J. Biol. Chem. 274, 30459-30467
43. Scrocchi, L. A., Brown, T. J., MacLusky, N., Brubaker, P. L., Auerbach, A. B., Joyner, A. L., and Drucker, D. J. (1996) Nat. Med. 2, 1254-1258
44. Sherwood, N. M., Krueckl, S. L., and McRory, J. E. (2000) Endocr. Rev. 21, 619-670
45. Lankat-Buttgereit, B., and Goke, B. (1997) Peptides (Elmsford) 18, 617-624
46. Galehshahi, F. S., Goke, B., and Lankat-Buttgereit, B. (1998) FEBS Lett. 436, 163-168
47. Wildhage, I., Trusheim, H., Goke, B., and Lankat-Buttgereit, B. (1999) Endocrinology 140, 624-631
48. Portois, L., Maget, B., Tastenoy, M., Perret, J., and Svoboda, M. (1999) J. Biol. Chem. 274, 8181-8190
49. Gutzwiller, J. P., Drewe, J., Goke, B., Schmidt, H., Rohrer, B., Lareida, J., and Beglinger, C. (1999) Am. J. Physiol. 276, R1541-R1544
50. Meeran, K., O'Shea, D., Edwards, C. M., Turton, M. D., Heath, M. M., Gunn, I., Abusnana, S., Rossi, M., Small, C. J., Goldstone, A. P., Taylor, G. M., Sunter, D., Steere, J., Choi, S. J., Ghatei, M. A., and Bloom, S. R. (1999) Endocrinology 140, 244-250
51. Scrocchi, L. A., and Drucker, D. J. (1998) Endocrinology 139, 3127-3132
52. Donahey, J. C. K., van Dijk, G. Woods, S. C., and Seeley, R. J. (1998) Brain Res. 779, 75-83
53. Thiele, T. E., van Dijk, G., Campfield, L. A., Smith, F. J., Burn, P., Woods, S. C., Bernstein, H., and Seeley, R. J. (1997) Am. J. Physiol. 272, R726-R730
54. Thiele, T. E., Seeley, R. J., D'Alessio, D., Eng, J., Bernstein, I. L., Woods, S. C., and van Dijk, G. (1998) Brain Res. 801, 164-170
55. Rinaman, L. (1999) Am. J. Physiol. 277, R1537-R1540
56. Goke, R., Fehmann, H.-C., Linn, T., Schmidt, H., Krause, M., Eng, J., and Gške, B. (1993) J. Biol. Chem. 268, 19650-19655
57. Alvarez, E., Roncero, I., Chowen, J. A., Thorens, B., and Blazquez, E. (1996) J. Neurochem. 66, 920-927
58. Sivarajah, P., Wheeler, M. B., and Irwin, D. M. (2001) Comp. Biochem. Physiol. 128, 517-527
59. Traber, P. G., and Silberg, D. G. (1996) Annu. Rev. Physiol. 58, 275-297
60. Boylan, M. O., Jepeal, L. I., Jarboe, L. A., and Wolfe, M. M. (1997) J. Biol. Chem. 272, 17438-17443
61. Dusing, M. R., Brickner, A. G., Lowe, S. Y., Cohen, M. B., and Wiginton, D. A. (2000) Am. J. Physiol. 279, G1080-G1093
62. Jin, T., and Drucker, D. J. (1996) Mol. Cell. Biol. 16, 19-28
63. Larsen, P. J., Tang-Christensen, M., and Jessop, D. S. (1997) Endocrinology 138, 4445-4455
64. MacLusky, N., Cook, S., Scrocchi, L., Shin, J., Kim, J., Vaccarino, F., Asa, S. L., and Drucker, D. J. (2000) Endocrinology 141, 752-762
65. Oka, J., Suzuki, E., and Kondo, Y. (2000) Brain Res. 878, 194-198
66. van Dijk, G., and Thiele, T. E. (1999) Neuropeptides 33, 406-414
67. Franklin, K., and Paxinos, G. (1997) The Mouse Brain in Sterotaxic Coordinates, Academic Press, Inc., San Diego, CA