A duodenum-specific enhancer regulates expression along three axes in the small intestine

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 5 42-5, 2000, Pages

  Dusing, Mary R ^a   Brickner, Anthony G ^a   Lowe, Sharon Y ^a   Cohen, Mitchell B ^a   Wiginton, Dan A ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

Cephalocaudal axis; Crypt villus axis; DNase I footprinting; PDX 1; Temporal regulation; Transgenic mice

Indexed keywords

ADENOSINE DEAMINASE; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CRYPT CELL; DNA FOOTPRINTING; DUODENUM; ENZYME REGULATION; GENE EXPRESSION; INTESTINE CELL; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE; TRANSGENE;

EID: 0033662954     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.5.g1080     Document Type: Article

References (61)

1. Structural and functional analysis of the murine adenosine deaminase gene
2. Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer
3. Dissecting a locus control region: Facilitation of enhancer function by extended enhancer-flanking sequences
4. Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene
5. Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression
6. Enhancers: Mechanisms of action and cell specificity
7. Factors involved in the duodenal expression of the human calbindin-D9k gene
8. Regulation and function of adenosine deaminase in mice
9. A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer
10. Reporter constructs with low background activity utilizing the cat gene
11. Identification of a murine homolog of the human adenosine deaminase thymic enhancer
12. Genomic sequence comparison of the human and mouse adenosine deaminase gene regions
13. Developmental expression of adenosine deaminase in the upper alimentary tract of mice
14. Regulation of duodenal specific expression of the human adenosine deaminase gene
15. Sp1 is essential for both enhancer-mediated and basal activation of the TATA-less human adenosine deaminase promoter
16. A central role for a single c-Myb binding site in a thymic locus control region
17. The Cdx-1 and Cdx- 2 homeobox genes in the intestine
18. Distinct functions are implicated for GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation
19. Intestinal epithelial differentiation: New insights from chimeric and transgenic mice
20. High efficiency DNA-mediated transformation of primate cells
21. Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization
22. 125I labeled RNA probes
23. An enhancer LEF-1/TCF-1 site is essential for insertion-site independent transgene expression in thymus
24. Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms
25. Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum
26. The murine adenosine deaminase promoter requires an atypical TATA box which binds transcription factor IID and transcriptional activity is stimulated by multiple upstream SP1 binding sites
27. Insulin-promoter-factor 1 is required for pancreatic development in mice
28. Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats
29. Rat lactase-phlorizin hydrolase/human growth hormone transgene is expressed on small intestinal villi in transgenic mice
30. Cis-acting elements and transcription factors involved in the intestinal specific expression of the rat calbindin-D9k gene
31. Cell type-specific transcriptional regulation of the human adenosine deaminase gene
32. Developmental changes of adenosine deaminase, xanthine oxidase, and uricase in mouse tissues
33. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
34. Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis, and small intestinal death
35. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
36. Development of the human gastrointestinal tract: Twenty years of progress
37. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
38. IPF1, a homeodomain-containing transactivator of the insulin gene
39. Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic α- and β-cells
40. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: Importance of the FPWMK motif and of the homeodomain
41. Tissue-specific and hormonal regulation of calbindin-D9K fusion genes in transgenic mice
42. Transcription factor AP-2γ regulates murine adenosine deaminase gene expression during placental development
43. Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placenta
44. A homeodomain protein related to caudal regulates intestine-specific gene transcription
45. An intestine-specific homeobox gene regulates proliferation and differentiation
46. Anatomy of an enhancer
47. Intestine-specific gene transcription
48. 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice
49. Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homeodomain protein Cdx-2
50. Developmental expression of SI is regulated in transgenic mice by an evolutionarily conserved promoter
51. Hereditary hemolytic anemia with increased red cell adenosine deaminase (45- to 70-fold) and decreased adenosine triphosphate
52. Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice
53. Complete sequence and structure of the gene for human adenosine deaminase
54. An intron 1 regulatory region from the murine adenosine deaminase gene can activate heterologous promoters for ubiquitous expression in transgenic mice
55. Coordinate developmental regulation of purine catabolic enzyme expression in gastrointestinal and post-implantation reproductive tracts
56. Regulation of forestomach-specific expression of the murine adenosine deaminase gene
57. Developmental competence of the gut endoderm: Genetic potentiation by GATA and HNF3/fork head proteins