Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats

Brain Research

Volumn 779, Issue 1-2, 1998, Pages 75-83

  Donahey, Jamie C K ^a   Van Dijk, Gertjan ^a   Woods, Stephen C ^a   Seeley, Randy J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Food intake; Obesity; Third ventricle; Zucker rat

Indexed keywords

GLUCAGON LIKE PEPTIDE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BODY WEIGHT; BRAIN THIRD VENTRICLE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; OBESITY; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; CEREBRAL VENTRICLES; FEEDING BEHAVIOR; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; INFUSION PUMPS, IMPLANTABLE; MALE; OBESITY; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RATS; RATS, ZUCKER; TIME FACTORS;

EID: 0031964636     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01057-3     Document Type: Article

References (24)

1. Chavez M., Seeley R.J., Woods S.C. A comparison between the effects of intraventricular insulin and intraperitoneal LiCl on three measures sensitive to emetic agents. Behav. Neurosci. 109:1995;547-550.
2. D'Alessio D.A., Vogel R., Prigeon R.L., Laschansky E., Koerker D., Eng J., Ensinck J.W. Elimination of the action of Glucagon-like Peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy humans. J. Clin. Investigation. 97:1996;133-138.
3. D'Alessio D.A., Thirlby R., Laschansky E.C., Zebroski H., Ensinck J.W. Response of GLP-1 to nutrients in humans. Digestion. 54:1993;377-379.
4. Drucker D.J., Asa S. Glucagon gene expression in vertebrate brain. J. Biol. Chem. 263:1988;13475-13478.
5. Goke R., Larsen P.J., Mikkelsen J.D., Skeikh S.P. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin is a ligand of brain GLP-1 sites. Eur. J. Neurosci. 7:1995;2294-2300.
6. I. Gunn, T. Humby, J. Herbert, J.M. Polak, S.R. Bloom, D. O'Shea, Glucagon-like peptide-1 in models of abnormal feeding and effect on behvaior, Society for Neuroscience Abstracts, 1996.
7. Han V.K.M., Hynes M.A., Jin C., Towle A.C., Lauder J.M., L. P.K. Cellular localization of proglucagon/glucagon-like peptide 1 messenger RNAs in rat brain. J. Neurosci. 16:1986;97-107.
8. Hermann C., Goke R., Richter G., Fehman H.C., Arnbold R., Goke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion. 56:1995;117-126.
9. Ikeda H., West D.B., Pustek J.J., Figlewicz D.P., Greenwood M.R.C., Porte D. Jr., Woods S.C. Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats. Appetite. 7:1986;381-386.
10. Jin S.L., Han V.K.M., Simmons J.G., Towle A.C., Lauder J.M., Lund P.K. Distribution of glucagonlike peptide 1, glucagon, and glicentin in the rat brain: An immunocutochemical study. J. Comp. Neurol. 271:1988;519-533.
11. Li B.H., Rowland N.E. Cholecystokinin- and dexfenfluramine-induced anorexia compared using devazepide and c-fos expression in the rat brain. Regul. Pept. 50:1994;223-233.
12. Maggio C.A., Haraczkiewicz E., Vasselli J.R. Diet composition alters the satiety effect of cholecystokinin in lean and obese Zucker rats. Physiol. Behav. 43:1988;485-491.
13. Polonsky B.D., Given E., Carter V. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81:1988;442-448.
14. Riedy C.A., Chavez M., Figlewicz D.P., Woods S.C. Central insulin enhances sensitivity to cholecystokinin. Physiol. Behav. 58:1995;755-760.
15. Seeley R.J., van Dijk G., Campfield L.A., Smith F.J., Nelligan J.A., Bell S.M., Baskin D.G., Woods S.C., Schwartz M.W. The effect of intraventricular administration of leptin on food intake and body weight in the rat. Horm. Metab. Res. 28:1996;664-668.
16. G.P. Smith, J. Gibbs, The development and proof of the cholecystokinin hypothesis of satiety, in C.T. Dourish, S.J. Cooper, S.D. Iversen, L.L. Iversen (Eds.), Multiple Cholecystokinin Receptors in the CNS, Oxford University Press, Oxford, 1992, pp. 166-182.
17. Tang-Christensen M., Larsen P.J., Goke R., Fink-Jensen A., Jessop D.S., Moller M., Sheikh S.P. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am. J. Physiol. 271:1996;R848-856.
18. Thiele T.E., van Dijk G., Campfield L.A., Smith F.J., Burn P., Woods S.C., Bernstein I.L., Seeley R.J. Central administration of GLP-1, but not leptin, produce conditioned taste aversions in the rat. Am. J. Physiol. 272:1997;R726-R730.
19. Turton M.D., O'Shea D., Gunn I., Beak S.A., Edwards C.M.B., Meeran K., Choi S.J., Taylor G.M., Heath M.M., Lambert P.D., Wilding J.P.H., Smith D.M., Ghatei M.A., Herbert J., Bloom S.R. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature. 379:1996;69-72.
20. van Dijk G., Thiele T.E., Donahey J.C.K., Campfield L.A., Smith F.J., Burn P., Bernstein I.L., Woods S.C., Seeley R.J. Central infusion of leptin and GLP-1 (7-36) amide differentially stimulate c-Fos-like immunoreactivity in the rat brain. Am. J. Physiol. 271:1996;R1096-R1100.
21. van Dijk G., Thiele T.E., Seeley R.J., Woods S.C., Bernstein I.L. Glucagon-like peptide-1 and satiety? Nature. 385:1997;214.
22. West D.B., Fey D., Woods S.C. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am. J. Physiol. 246:1984;R776-87.
23. Woods S.C., Lotter E.C., McKay L.D., Porte D. Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature. 282(5738):1979;503-505.
24. Zhang Y., Proenca R., Maffie M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.