Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina

Brain Research

Volumn 904, Issue 1, 2001, Pages 177-188

  Chen, T A ^a   Yang, Fusheng ^b   Cole, Greg M ^b   Chan, S O ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; CED3 ICE proteases; CPP32; Fractin antibody

Indexed keywords

ACETYLASPARTYLGLUTAMYLVALYLASPARTIC ACID ALDEHYDE; ACETYLTYROSYLVALYLALANYLASPARTIC ACID ALDEHYDE; ACTIN; ANTIBODY; CASPASE 3; CASPASE INHIBITOR; DNA FRAGMENT; FRACTIN ANTIBODY; GLUTAMIC ACID; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA CELL;

ANIMALS; APOPTOSIS; CARBOCYANINES; CASPASE 1; CASPASE 3; CASPASES; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; DIZOCILPINE MALEATE; DNA FRAGMENTATION; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; FLUORESCENT DYES; GLUTAMIC ACID; IN SITU NICK-END LABELING; NERVE DEGENERATION; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL GANGLION CELLS;

EID: 0035876301     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02485-4     Document Type: Article

References (62)

1. Human ICE/CED-3 protease nomenclature
2. Fas-induced activation of cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors
3. Neural apoptosis
4. Cytochrome c release and caspase activation in traumatic axonal injury
5. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
6. Developmental changes produced in the retinofugal pathways of rats and ferrets by early monocular enucleations: The effect of age and the differences between normal and albino animals
7. Enlargement of uncrossed retinal projections in the albino rat: Additive effects of neonatal eye removal and thalamectomy
8. Caspase inhibitors block the retinal ganglion cell death following optic nerve transection
9. Induction of caspase-3-like protease mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
10. Glutamate neurotoxicity and diseases of the nervous system
11. Calcium: Still center-stage in hypoxic-ischemic neuronal death
12. Oxidative stress, glutamate, and neurodegenerative disorders
13. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
14. Retinal TUNEL-positive cells and high glutamate levels in vitreous humor of mutant quail with a glaucoma-like disorder
15. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
16. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
17. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
18. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
19. Mch2, a new member of the apoptotic Ced-3/ICE cysteine protease gene family
20. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
21. Prevention of vertebrate neuronal death by crmA gene
22. Apoptosis: Molecular regulation of cell death
23. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease
24. Inhibition of interleukin-1 beta-converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
25. Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) product
26. Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases
27. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo
28. Altered gene expression in brain ischemia
29. Decreased apoptosis in the brain and premature lethality in CPP32-deficiency mice
30. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme
31. N-methyl-D-aspartate (NMDA)-induced apoptosis in rat retina
32. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
33. Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders
34. Purification and characterization of an interleukin-1 beta-converting enzyme family protease that activates cysteine protease P32 (CPP32)
35. 2+ influx elicited by glutamate: Role in neuronal death
36. Protease activation during apoptosis: Death by a thousand cuts?
37. Actin cleavage by CPP-32/apopain during the development of apoptosis
38. Excitatory amino acid neurotoxicity and neurodegenerative disease
39. Induction of apoptosis in fibroblasts by IL-1 β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
40. Neurochemical changes following postmortem ischemia in the rat retina
41. Identification and inhibition of the ICE/Ced-3 protease necessary for mammalian apoptosis
42. Neuronal necrosis and apoptosis: Two distinct events induced by exposure to glutamate or oxidative stress
43. Glutamate-induced retinal degeneration in neonatal mice: Electron microscopy of the acutely evolving lesion
44. DNA fragmentation characteristic of apoptosis and cell loss induced by kainic acid in rabbit retinas
45. Role of poly(ADP-ribose) formation in DNA repair
46. CPP32/apopain is a key interleukin-1 β-converting enzyme-like protease involved in Fas-mediated apoptosis
47. N-methyl-D-aspartate induced neurotoxicity in the adult rat retina
48. Histologic changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate
49. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8 and -10 in a caspase-9-dependent manner
50. Resistance of actin to cleavage during apoptosis
51. Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury
52. The Ced-3/interleukin-1 beta-converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
53. Apoptotic signaling
54. Molecular characterization of mitochondrial apoptosis-inducing factor
55. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
56. Apoptosis is induced by excitotoxicity in goldfish retina
57. An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy
58. 2+-induced apoptosis through calcineurin dephosphorylation of BAD
59. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis
60. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
61. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease