Short- and long-term effects of ciliary neurotrophic factor on androgen- sensitive motoneurons in the lumbar spinal cord

Journal of Neurobiology

Volumn 31, Issue 2, 1996, Pages 263-273

  Bengston, Lynn ^a   Lopez, Veronica ^b   Watamura, Scott ^b   Forger, Nancy G ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

androgen; ciliary neurotrophic factor; moroneuron; muscle; spinal cord

Indexed keywords

CILIARY NEUROTROPHIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL SIZE; CONTROLLED STUDY; FEMALE; HORMONE SENSITIVITY; LUMBAR SPINAL CORD; MALE; MOTONEURON; NONHUMAN; PERINEUM; PRIORITY JOURNAL; RAT;

AGE FACTORS; ANDROGENS; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CELL COUNT; CELL DEATH; CELL DIFFERENTIATION; CELL SIZE; CILIARY NEUROTROPHIC FACTOR; FEMALE; HINDLIMB; MOTOR NEURONS; MUSCLE, SKELETAL; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PERINEUM; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0029794725     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(199610)31:2<263::AID-NEU10>3.0.CO;2-J     Document Type: Article

References (52)

1. BREFDLOVE, S. M. and ARNOLD, A. P. (1983). Hormonal control of a developing neuromuscular system: II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus. J. Neurosci. 3:424-432.
2. BREEDLOVE, S. M., JACOBSON, C. D., GORSKI, R. A., and ARNOLD, A. P. (1982). Masculinization of the female rat spinal cord following a single neonatal injection of testosterone propionate but not estradiol benzoate. Brain Res. 237:173-181.
3. CIHAK, R., GUTMANN, E., and HANZLIKOVA, V. (1970). Involution and hormone-persistence of the M. Sphincter (levator) ani in female rats. J. Anat. 106: 93-110.
4. CLARK, M. M., CREWS, D., and GALEF, B. G. (1991). Concentrations of sex steroid hormones in pregnant and fetal Mongolian gerbils. Physiol. Behav. 49:239-243.
5. CLARKE, P. G. H. (1994). Neuronal death in the development of the vertebrate central nervous system. Semin. Neurosci. 6:291-297.
6. CLARKE, P. G. H. and OPPENHEIM, R. W. (1995). Neuron death in vertebrate development: in vivo methods. Methods Cell Biol. 46:277-321.
7. FISHMAN, R. B. and BREEDLOVF, S. M.( 1988). Neonatal androgen maintains sexually dimorphic muscles in the absence of innervation. Muscle Nerve 11:553-560.
8. FISHMAN, R. B., CHISM, L., FIRESTONE, G. L., and BREEDLOVE, S. M. (1990). Evidence for androgen receptors in sexually dimorphic perineal muscles of neonatal male rats. Absence of androgen accumulation by the perineal motoneurons. J. Neurobiol. 21:694-704.
9. FORGER, N. G., GALEF, B. G., and CLARK, M. M. (1996). Intrauterine position affects motoneuron number and muscle size in a sexually dimorphic neuromuscular system. Brain Res., to appear.
10. FORGER, N. G., ROBERTS, S. L., WONG, V., and BREEDLOVE, S. M. (1993). Ciliary neurotrophic factor maintain motoneurons and their target muscles in developing rats. J. Neurosci. 13:4720-4726.
11. FORGER, N. G., WONG, V., and BREEDLOVE, S. M. (1995). Ciliary neurotrophic factor arrests muscle and motoneuron degeneration in androgen-insensitive rats. J. Neurobiol. 28:354-362.
12. HAMBURGER, V. (1975). Cell death in the development of the lateral motor column of the chick embryo. J. Comp. Neurol. 160:535-546.
13. HARRIS, A. J. and MCCAIG, C. D. (1984). Motoneuron death and motor unit size during embryonic development of the rat. J. Neurosci. 4:13-24.
14. HELGREN, M. E., SQUINTO, S. P., DAVIS, H. L., PARRY, D. J., BOULTON, T. G., HECK, C. S., ZHU, Y., YANCOPOULOS, G. D., LINDSAY, R. M., and DISTEFANO, P. S. (1994). Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle. Cell 76:493-504.
15. HENDERSON, J. T., SENIUK, N. A., RICHARDSON, P. M., GAULDIE, J., and RODER, J. C. (1994). Systemic administration of ciliary neurotrophic factor induces cachexia in rodents. J. Clin. Invest. 93:2632-2638.
16. HODGES, L. L., JORDAN, C. L., and BREEDLOVE, S. M. (1993). Hormone-sensitive periods for the control of motoneuron number and soma size in the dorsolateral nucleus of the rat spinal cord. Brain Res. 602:187-190.
17. HOUENOU, L. J., LI, L., LO, A.C., YAN, Q., and OPPENHEIM, R. W. (1994). Naturally occurring and axotomy-induced motoneuron death and its prevention by neurotrophic agents: a comparison between chick and mouse. Prog. Brain Res. 102:217-226.
18. IKEDA, K., WONG, V., HOLMLUND, T. H., GREENE, T., CEDARBAUM, J. M., LINDSAY, R. M., and MITSUMOTO, H. (1995). Histomeric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Ann. Neurol. 37:47-54.
19. IP, N. Y., MCCLAIN, J., BARREZUETA, N. X., ALDRICH, T. H., PAN, L., LI, Y., WIEGAND, S. J., FRIEDMAN, B., DAVIS, S., and YANCOPOULOS, G. D. (1993). The a component of the CNTF receptor is required for signalling and defines potential CNTF targets in the adult and during development. Neuron 10:89-102.
20. JORDAN, C. L. (1996). Ciliary neurotrophic factor may act in target musculature to regulate developmental synapse elimination. Dev. Neurosci., to appear.
21. JORDAN, C. L., BREEDLOVE, S. M., and ARNOLD, A. P. (1982). Sexual dimorphism and the influence of neonatal androgen in the dorsolateral motor nucleus of the rat lumbar spinal cord. Brain Res. 249:309-314.
22. KONIGSMARK, B. W. (1970). Methods for the counting of neurons. In: Contemporary Research Methods in Neutroanatomy. W. J. H. Nauta and S. O. E. Ebbesson, Eds. Springer-Verlag, New York, pp. 315-340.
23. LANCE-JONES, C. (1982). Motoneuron cell death in the developing lumbar spinal cord of the mouse. Dev. Brain Res. 4:473-479.
24. LANDIS, S. C. (1994). Development of sympathetic neurons: neurotransmitter plasticity and differentiation factors. Prog. Brain Res. 100:19-23.
25. LILLIEN, L. E., SENDTNER, M., ROHRER, H., HUGHES, S. M., and RAFF, M. C. (1988). Type-2 astrocyte development in rat brain cultures is initiated by a CNTF-like protein produced by type-1 astrocytes. Neuron 1: 485-494.
26. MCKENNA, K. E. and NADELHAFT, I. (1986). Organization of the pudendal nerve in the male and female rat. J. Comp. Neurol. 240:532-549.
27. METSIS, M., TIMMUSK, T., ALLIKMETS, R., SAARMA, M., and PERSSON, H. (1992). Regulatory and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter. Gene 121:247-254.
28. MITSUMOTO, H., IKEDA, K., HOLMLUND, T., GREENE, T., CEDARBAUM, J. M., WONG, V., and LINDSAY, R. M. (1994). The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann. Neurol. 36:142-148.
29. NICOLOPOULOS-STOURNARAS, S. and ILES, J. F. (1983). Motor neuron columns in the lumbar spinal cord of the rat. J. Comp. Neurol. 217:75-85.
30. NORDEEN, E. J., NORDEEN, K. W., SENGELAUB, D. R., and ARNOLD, A. P. (1985). Androgen prevents normally occurring cell death in a sexually dimorphic spinal nucleus. Science 229:671-673.
31. OPPENHEIM, R. W. (1986). The absence of significant postnatal motoneuron death in the brachial and lumbar spinal cord of the rat. J. Comp. Neurol. 246:281-286.
32. OPPENHEIM, R. W. (1991). Cell death during development of the nervous system. Annu. Rev. Neurosci. 14: 453-501.
33. OPPENHEIM, R. W., HOUENOU, L. J., JOHNSON, J. E., LIN, L.-F. H., LI, L., LO, A. C., NEWSOME, A. L., PREVETTE, D. M., and WANG, S. (1995). Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373:344-346.
34. OPPENHEIM, R. W., PREVETTE, D., QIN-WEI, Y., COLLINS, F., and MACDONALD, J. (1991). Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science 251:1616-1618.
35. PATTEN, B. M. (1953). Human Embryology. Blackiston, New York, pp. 306-307.
36. PERSSON, H., AYER-LELIEVRE, C., SÖDER, O., VILLAR, M. J., METSIS, M., OLSON, L., RITZEN, M., and HÖKFELT, T. (1990). Expression of B-nerve growth factor receptor MRNA in sertoli cells downregulated by testosterone. Science 247:704-707.
37. REITH, E. J. and Ross, M. H. (1977). Atlas of Descriptive Histology. Harper & Row, New York, p. 234.
38. SACHS, B. D. (1982). Role of the rat's striated penile muscles in penile reflexes, copulation and the induction of pregnancy. J. Reprod. Fertil. 66:433-443.
39. SAGOT, Y., TAN, S. A., BAETGE, E., SCHMALBRUCH, H., KATO, A. C., and AEBISHER, P. (1995). Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse. Eur. J. Neurosci. 7:1313-1322.
40. SCHRODER, H. D. (1980). Organization of the motoneurons innervating the pelvic muscles of the male rat. J. Comp. Neurol. 192:567-587.
41. SENDTNER, M., KREUTZBERG, G. W., and THOENEN, H. (1990). Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345:440-441.
42. SENDTNER, M., SCHMALBRUCH, H., STÖCKLI, K. A., CARROLL, P., KREUTZBERG, G. W., and THOENEN, H. (1992). Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358:502-504.
43. SENGELAUB, D. R. and ARNOLD, A. P. (1989). Hormonal control of neuron number in sexually dimorphic spinal nuclei of the rat: I. Testosterone-regulated death in the dorsolateral nucleus. J. Comp. Neurol. 280:622-629.
44. SENGELAUB, D. R., JORDAN, C. L., KURZ, E. M., and ARNOLD, A. P. (1989). Hormonal control of neuron number in sexually dimorphic spinal nuclei of the rat. II. Development of the spinal nucleus of the bulbocavcrnosus in androgen-insensitive (Tfm) rats. J. Comp. Neuol. 280:630-636.
45. SOHRABJI, F., GREENE, L. A., MIRANDA, R. C., and TORAN-ALLERAND, C. D. (1994). Reciprocal regulation of estrogen and NGF receptors by their ligands in PC 12 cells. J. Neurobiol. 25:974-988.
46. TOBIN, C. and JOUBERT, Y. (1988). The levator ani of the female rat: a suitable model for studying the effects of testosterone on the development of mammalian muscles. Biol. Struct. Morphogen. 1:28-33.
47. ULENKATE, H. J. L. M., KAAL, E. C. A., and JENNEKENS, F. G. I. (1995). Ciliary neurotrophic factor induces hypophagia, hypodipsia, and diminished weight gain in young adult rats. Neurosci. Res. Comm. 16:67-73.
48. VEJSADA, R., SAGOT, Y., and KATO, A. C. (1995). Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized moloneurons in vivo. Eur. J. Neurosci. 7:108-115.
49. VOM SAAL, F. S. and BRONSON, F. H. (1980). Sexual characteristics of adult female mice are correlated with their blood testosterone levels during prenatal development. Science 208:597-599.
50. WALLACH, S. J. R. and HART, B. J. (1983). The role of the striated penile muscles of the male rat in seminal plug dislodgement and deposition. Physiol. Behav. 31: 815-821.
51. XU, J. and FORGER, N. G. (1995). Neurotrophic factor expression in the androgen-sensitive bulbocavernosus muscle. Soc. Neurosci. Abstr. 21:2014.
52. ZHOU, Z.-X., WONG, C.-I., SAR, M., and WILSON, E. M. (1994). The androgen receptor: an overview. Recent Prog. Horm. Res. 49:249-273.