Sexual dimorphism in the spinal cord is absent in mice lacking the ciliary neurotrophic factor receptor

Journal of Neuroscience

Volumn 17, Issue 24, 1997, Pages 9605-9612

  Forger, Nancy G ^a   Howell, Michelle L ^a   Bengston, Lynn ^a   MacKenzie, Laura ^a   DeChiara, Thomas M ^b   Yancopoulos, George D ^b  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Androgen; Ciliary neurotrophic factor; Knockout mice; Motoneuron; Sexual dimorphism

Indexed keywords

ANDROGEN; CILIARY NEUROTROPHIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; MOTONEURON; MOUSE; NEUROMUSCULAR SYSTEM; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SPINAL CORD;

EID: 0031470894     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-24-09605.1997     Document Type: Article

References (14)

1. Bengston L, Lopez V, Watamura S, Forger NG (1996) Short- and long-term effects of ciliary neurotrophic factor on androgen-sensitive motoneurons in the lumbar spinal cord. J Neurobiol 31:263-273.
2. Breedlove SM (1985) Hormonal control of the anatomical specificity of motoneuron-to-muscle innervation in rats. Science 227:1357-1359.
3. Breedlove SM, Arnold AP (1980) Hormone accumulation in a sexually dimorphic motor nucleus in the rat spinal cord. Science 210:564-566.
4. Breedlove SM, Arnold AP (1981) Sexually dimorphic motor nucleus in the rat lumbar spinal cord: response to adult hormone manipulation, absence in androgen-insensitive rats. Brain Res 225:297-307.
5. Breedlove SM, Arnold AP (1983) Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus. J Neurosci 3:424-432.
6. Chu-Wang I-W, Oppenheim RW (1978) Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development. J Comp Neurol 177:33-58.
7. Cihak R, Gutmann E, Hanzlikova V (1970) Involution and hormone-induced persistence of the muscle sphincter (levator) ani in female rats. J Anat (Lond) 106:93-110.
8. Davis S, Aldrich TH, Stahl N, Pan L, Taga T, Kishimoto T, Ip NY, Yancopoulos GD (1993a) LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260:1805-1808.
9. Davis S, Aldrich TH, Ip NY, Stahl N, Scherer S, Farruggella T, DiStefano PS, Curtis R, Panayotatos N, Gascan H, Chevalier S, Yancopoulos GD (1993b) Released form of CNTF receptor α component as a soluble mediator of CNTF response. Science 259:1736-1739.
10. DeChiara TM, Vejsada R, Poueymirou WT, Acheson A, Suri C, Conover JC, Friedman B, McClain J, Pan L, Stahl N, Ip NY, Kato A, Yancopoulos GD (1995) Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83:313-322.
11. Fishman RB, Breedlove SM (1988) Neonatal androgen maintains sexually dimorphic motoneurons in the absence of innervation. Muscle Nerve 11:553-560.
12. Fishman RB, Chism L, Firestone GL, Breedlove SM (1990) Evidence for androgen receptors in sexually dimorphic perineal muscles of neonatal male rats. Absence of androgen accumulation by the perineal motoneurons. J Neurobiol 21:694-704.
13. Lance-Jones C (1982) Motoneuron cell death in the developing lumbar spinal cord of the mouse. Dev Brain Res 4:473-479.
14. Lin L-FH, Mismer D, Lile JD, Armes LG, Butler ET, Vannice JL, Collins F (1989) Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science 246:1023-1025.