Ontogeny of androgen receptor immunoreactivity in lumbar motoneurons and in the sexually dimorphic levator ani muscle of male rats

Journal of Comparative Neurology

Volumn 379, Issue 1, 1997, Pages 88-98

  Jordan, Cynthia L ^a   Padgett, Barbara ^a   Hershey, Jacob ^a   Prins, Gail ^b   Arnold, Arthur ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

motor pools; neuromuscular; sexual differentiation; spinal cord; steroid hormones

Indexed keywords

ANDROGEN RECEPTOR; STEROID HORMONE; TESTOSTERONE PROPIONATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; IMMUNOREACTIVITY; LEVATOR ANI MUSCLE; LUMBAR SPINAL CORD; MALE; MOTONEURON; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SEX DIFFERENTIATION;

ANIMALS; ANTIBODY SPECIFICITY; IMMUNOHISTOCHEMISTRY; LUMBOSACRAL REGION; MALE; MOTOR NEURONS; MUSCLE DEVELOPMENT; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; SEX CHARACTERISTICS; SPINAL CORD; TESTOSTERONE;

EID: 0031055139     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19970303)379:1<88::AID-CNE6>3.0.CO;2-E     Document Type: Article

References (44)

1. Bingaman, E.W., L.M, Baeckman, J.M. Yracheta, R.J. Handa, and T.S. Gray (1994) Localization of androgen receptor within peptidergic neurons of the rat forebrain. Brain Res. Bull. 35:379-382.
2. Breedlove, S.M. (1992) Sexual dimorphism in the vertebrate nervous system. J. Neurosci. 12:4133-4142.
3. Breedlove, S.M., and A.P. Arnold (1980) Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord. Science 210:564-566.
4. Breedlove, S.M., and A.P. Arnold (1981) Sexually dimorphic motor nucleus in rat spinal cord: Response to adult hormone manipulation, absence in androgen insensitive rats. Brain Res. 225:297-307.
5. Breedlove, S.M., and A.P. Arnold (1983a) Hormonal control of a developing neuromuscular system: I. Complete demasculinization of the male rat spinal nucleus of the bulbocavernosus using the antiandrogen flutamide. J. Neurosci. 3:417-423.
6. Breedlove, S.M., and A.P. Arnold (1983b) Sex differences in the pattern of steroid accumulation by motoneurons in the rat lumbar spinal cord. J. Comp. Neurol. 215:211-216.
7. Breedlove, S.M., C.D. Jacobson, R.A. Gorski, and A.P. Arnold (1982) Masculinization of the female rat spinal cord following a single neonatal injection of testosterone propionate but estradiol benzoate. Brain Res. 237:173-181.
8. Corpechot, C., E.E. Baulieu, and P. Robel (1981) Testosterone, dihydrotestosterone and androstanediols in plasma, testes and prostates of rats during development. Acta Endocrinol. 96:127-135.
9. Dionne, F.T., J.Y. Dube, R.L. Lesage, and R.R. Tremblay (1979) In vivo androgen binding in rat skeletal and perineal muscles. Acta Endocrinol. 91:362-372.
10. Dorlochter, M., S.H. Astrow, and A.A. Herrera (1994) Effects of testosterone on a sexually dimorphic frog muscle: Repeated in vivo observations and androgen receptor distribution. J. Neurobiol. 25:897-916.
11. Dube, J.Y., R. Leage, and R.R. Tremblay (1976) Androgen and estrogen binding in rat skeletal and perineal muscles. Can. J. Biochem. 54:50-55.
12. Fishman, R.B., L. Chism, G.L. Firestone, and S.M. Breedlove (1990) Evidence for androgen receptors in sexually dimorphic perineal muscles of neonatal male rats. J. Neurobiol. 21:694-704.
13. Freeman, L.M., and S.M. Breedlove (1993) Steroid receptors in the central nervous system. Methods Neurosci. 11:1-15.
14. Freeman, L.M., B.A. Padgett, G.S. Prins, and S.M. Breedlove (1995) Distribution of androgen receptor immunoreactivity in the spinal cord of wild-type, androgen-insensitive and gonadectomized male rats. J. Neurobiol. 27:51-59.
15. Goldstein, L.A., E.M. Kurz, and D.R. Sengelaub (1990) Androgen regulation of dendritic growth and retraction in the development of a sexually dimorphic spinal nucleus. J. Neurosci. 10:935-946.
16. Huang, X., and R.E. Harlan (1994) Androgen receptor immunoreactivity in somatostatin neurons of the periventricular nucleus but not in the bed nucleus of the stria terminalis in male rats. Brain Res. 652:291-296.
17. Hussman, D.A., C.M. Wilson, M.J. McPhaul, W.D. Tilley, and J.D. Wilson (1990) Antipeptide antibodies to two distinct regions of the androgen receptor localize the receptor protein to the nuclei of target cells in the rat and human prostate. Endocrinology 126:2359-2368.
18. Jenster, G., H.A.G.M. van der Korput, C. van Vroonhoven, T.H. van Kwast, J. Trapman, and A.O. Brinkmann (1991) Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Mol. Endocrinol. 5:1396-1404.
19. Jenster, G., J. Trapman, and A.O. Brinkmann (1993) Nuclear import of the human androgen receptor. Biochem. J. 293:761-768.
20. Jordan, C.L., S.M. Breedlove, and A.P. Arnold (1982) Sexual dimorphism and the influence of neonatal androgen in the dorsolateral motor nucleus of the rat lumbar spinal cord. Brain Res. 249:309-314.
21. Jordan, C.L., M.S. Letinsky, and A.P. Arnold (1988) Synapse elimination occurs late in the hormone-sensitive levator ani muscle of the rat. J. Neurobiol. 19:335-356.
22. Jordan, C.L., M.S. Letinsky, and A.P. Arnold (1989a) The role of gonadal hormones in neuromuscular synapse elimination in rats: I. Androgen delays the loss of multiple innervation in the levator ani muscle. J Neurosci. 9:229-247.
23. Jordan, C.L., M.S. Letinsky, and A.P. Arnold (1989b) The role of gonadal hormones in neuromuscular synapse elimination in rats: II. Multiple innervation persists in the adult levator ani after juvenile androgen treatment. J. Neurosci. 9:239-247.
24. Jordan, C.L., S.M. Breedlove, and A.P. Arnold (1991) Ontogeny of steroid accumulation in spinal lumbar motoneurons of the rat: Implications for androgen's site of action during synapse elimination. J. Comp. Neurol. 313:441-448.
25. Jordan, C.L., P. Pawson, A.P. Arnold, and A.D. Grinnell (1992) Hormonal regulation of motor unit size and synaptic strength during synapse elimination in the rat levator ani muscle. J. Neurosci. 12:4447-4459.
26. Jordan, C.L., S. Watamura, and A.P. Arnold (1995) Androgenic, not estrogenic, steroids alter neuromuscular synapse elimination in the rat levator ani. Dev. Brain Res. 84:225-232.
27. Kashon, M.L., and C.L. Sisk (1994) Pubertal maturation is associated with an increase in the number of androgen receptor-immunoreactive cells in the brain of male ferrets. Dev. Brain Res. 78:237-242.
28. Lubischer, J.L., C.L. Jordan, and A.P. Arnold (1991) Transient and permanent effects of androgen treatment during synapse elimination in the levator ani muscle of the rat. J. Neurobiol. 23:1-9.
29. McKenna, K.E., and I. Nadelhaft (1986) The organization of the pudendal nerve in the male and female rat. J. Comp. Neurol. 248:532-549.
30. Menard, C.S., and R.E. Harlan (1993) Up-regulation of androgen receptor immunoreactivity in the rat brain by androgenic-anabolic steroids. Brain Res. 622:226-236.
31. Nordeen, E.J., K.W. Nordeen, D.R. Sengelaub, and A.P. Arnold (1985) Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus. Science 229:671-673.
32. Ontell, M., and R.F. Dunn (1978) Neonatal muscle growth: A quantitative study. Am. J. Anat. 152:539-556.
33. Pestronk, A., and D.B. Drachman (1978) A new stain for quantitative measurement of sprouting at neuromuscular junctions. Muscle Nerve 1:70-74.
34. Prins, G.S., and L. Birch (1993) Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement. Endocrinology 132:169-178.
35. Prins, G.S., L. Birch, and G.L. Greene (1991) Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology 129:3187-3199.
36. Schroder, H.D. (1980) Organization of the motoneurons innervating the pelvic muscles of the rat. J. Comp. Neurol. 192:567-587.
37. Sengelaub, D.R., and A.P. Arnold (1989) Hormonal control of neuron number in sexually dimorphic spinal nuclei of the rat: I. Testosterone-regulated death in the dorsolateral nucleus. J. Comp. Neurol. 280:622-629.
38. Simental, J.A., M. Sar, M.V. Lane, F.S. French, and E.M. Wilson (1991) Transcriptional activation and nuclear targeting signals of the human androgen receptor. J. Biol. Chem. 266:510-518.
39. Simerly, R.B. (1993) Distribution and regulation of steroid hormone receptor gene expression in the central nervous system. Adv. Neurol. 59:207-226.
40. Strahle, U., M. Boshart, G. Klock, F. Stewart, and G. Schutz (1989) Glucocorticoid-and progesterone-specific effects are determined by differential expression of the respective hormone receptors. Science 339: 629-632.
41. Wainman, P., and G.C. Shipounoff (1941) The effects of castration and testosterone propionate on the striated perineal musculature in the rat. Endocrinology 29:975-978.
42. Wood. R.I., and S.W. Newman (1993) Intracellular partitioning of androgen receptor immunoreactivity in the brain of the male Syrian hamster: Effects of castration and steroid replacement. J. Neurobiol. 24:925-938.
43. Woodward, J.A., D.G. Bonett, and M. Brecht (1990) Introduction to Linear Models and Experimental Design. New York: Harcourt Brace and Jovanovich Publishers, Academic Press.
44. Zhou, Z.X., M.V. Lane, J.A. Kemppainen, F.S. French, and E.M. Wilson (1995) Specificity of ligand-dependent androgen receptor stabilization: Receptor domain interactions influence ligand dissociation and receptor stability. Mol. Endocrinol. 9:208-218.