메뉴 건너뛰기




Volumn 10, Issue 1, 1998, Pages 60-64

Biology of thrombopoietin

Author keywords

[No Author keywords available]

Indexed keywords

HEMOPOIETIC GROWTH FACTOR; THROMBOPOIETIN;

EID: 0031900406     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-199802000-00012     Document Type: Review
Times cited : (13)

References (36)
  • 1
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon I, Mornon J-P, Cocault L, Mitjavila M-T, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci U S A 1992, 89:5640-6544.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5640-6544
    • Vigon, I.1    Mornon, J.-P.2    Cocault, L.3    Mitjavila, M.-T.4    Tambourin, P.5    Gisselbrecht, S.6    Souyri, M.7
  • 2
    • 0027225872 scopus 로고
    • Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis
    • Methia N, Louache F, Vainchenker W, Wendling F: Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993, 82:1395-1401.
    • (1993) Blood , vol.82 , pp. 1395-1401
    • Methia, N.1    Louache, F.2    Vainchenker, W.3    Wendling, F.4
  • 6
    • 0028117771 scopus 로고
    • The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production
    • Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci U S A 1994, 91:11104-11108.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11104-11108
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 9
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • Kuter DJ, Rosenberg RD: The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995, 85:2720-2730.
    • (1995) Blood , vol.85 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 12
    • 0030964546 scopus 로고    scopus 로고
    • Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice
    • Shivdasani RA, Fielder P, Keller G-A, Orkin SH, de Sauvage FJ: Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood 1997, 90:1821-1827.
    • (1997) Blood , vol.90 , pp. 1821-1827
    • Shivdasani, R.A.1    Fielder, P.2    Keller, G.-A.3    Orkin, S.H.4    De Sauvage, F.J.5
  • 13
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons RVB, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR: Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996, 87:4068-4071.
    • (1996) Blood , vol.87 , pp. 4068-4071
    • Emmons, R.V.B.1    Reid, D.M.2    Cohen, R.L.3    Meng, G.4    Young, N.S.5    Dunbar, C.E.6    Shulman, N.R.7
  • 14
    • 0029858508 scopus 로고    scopus 로고
    • Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: Insight into the regulation of platelet production
    • Chang M, Suen Y, Meng G, Buzby JS, Bussel J, Shen V, van de Ven C, Cairo MS: Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. Blood 1996, 88:3354-3362.
    • (1996) Blood , vol.88 , pp. 3354-3362
    • Chang, M.1    Suen, Y.2    Meng, G.3    Buzby, J.S.4    Bussel, J.5    Shen, V.6    Van De Ven, C.7    Cairo, M.S.8
  • 18
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl
    • Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 1996, 87:2162-2170.
    • (1996) Blood , vol.87 , pp. 2162-2170
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3    Li, R.4    Metcalf, D.5
  • 20
    • 0029864161 scopus 로고    scopus 로고
    • Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice
    • Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC: Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 1996, 24:265-269.
    • (1996) Exp Hematol , vol.24 , pp. 265-269
    • Kaushansky, K.1    Lin, N.2    Grossmann, A.3    Humes, J.4    Sprugel, K.H.5    Broudy, V.C.6
  • 21
    • 0030921072 scopus 로고    scopus 로고
    • Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion
    • Neelis KJ, Qingliang L, Thomas GR, Cohen BL, Eaton DL, Wagemaker G: Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion. Blood 1997, 90:58-63. This article shows that treatment with rhTPO enhanced platelet recovery in myelosuppressed primates. As would have been predicted from the studies of myelosuppressed mice treated with thrombopoietin, rhTPO also stimulated erythropoiesis in vivo. However, the effect of rhTPO on erythropoiesis in the primates was curbed by the development of functional iron deficiency.
    • (1997) Blood , vol.90 , pp. 58-63
    • Neelis, K.J.1    Qingliang, L.2    Thomas, G.R.3    Cohen, B.L.4    Eaton, D.L.5    Wagemaker, G.6
  • 22
    • 0023120533 scopus 로고
    • Correction of the anemia of end-stage renal disease with recombinant human erythropoietin
    • Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW: Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 1987, 316:73-78.
    • (1987) N Engl J Med , vol.316 , pp. 73-78
    • Eschbach, J.W.1    Egrie, J.C.2    Downing, M.R.3    Browne, J.K.4    Adamson, J.W.5
  • 23
    • 0030966361 scopus 로고    scopus 로고
    • Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in cancer patients
    • Vadhan-Raj S, Murray LJ, Bueso-Ramos C, Patel S, Reddy SP, Hoots WK, Johnston T, Papadopolous NE, Hittelman WN, Johnston DA, et al.: Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in cancer patients. Ann Intern Med 1997, 126:673-681. In the patients in this study, the platelet count began to rise at day 4 and peaked at day 12 after a single dose of rhTPO. Multiple classes of progenitor cells were mobilized into the blood. The half-life of rhTPO in vivo was long: 20 to 30 hours.
    • (1997) Ann Intern Med , vol.126 , pp. 673-681
    • Vadhan-Raj, S.1    Murray, L.J.2    Bueso-Ramos, C.3    Patel, S.4    Reddy, S.P.5    Hoots, W.K.6    Johnston, T.7    Papadopolous, N.E.8    Hittelman, W.N.9    Johnston, D.A.10
  • 24
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
    • Basser RL, Rasko JEJ, Clarke K, Cebon J, Green MD, Hussein S, Alt C, Menchaca D, Tomita D, Marty J, et al.: Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 1996, 348:1279-1281.
    • (1996) Lancet , vol.348 , pp. 1279-1281
    • Basser, R.L.1    Rasko, J.E.J.2    Clarke, K.3    Cebon, J.4    Green, M.D.5    Hussein, S.6    Alt, C.7    Menchaca, D.8    Tomita, D.9    Marty, J.10
  • 25
    • 10344238601 scopus 로고    scopus 로고
    • Administration of pegylated human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation
    • O'Malley CJ, Rasko JEJ, Basser RL, McGrath KM, Cebon J, Grigg AP, Hopkins W, Cohen B, O'Byrne J, Green MD, et al.: Administration of pegylated human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation. Blood 1996, 88:3288-3298.
    • (1996) Blood , vol.88 , pp. 3288-3298
    • O'Malley, C.J.1    Rasko, J.E.J.2    Basser, R.L.3    McGrath, K.M.4    Cebon, J.5    Grigg, A.P.6    Hopkins, W.7    Cohen, B.8    O'Byrne, J.9    Green, M.D.10
  • 26
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi M, Glaspy J, Crawford J, Garst J, Figlin R, Sheriday W, Menchaca D, Tomita D, Ozer H, Harker L: Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997, 336:404-409. This randomized double-bund placebo-controlled dose escalation trial of PEG-rHuMGDF in patients undergoing chemotherapy for lung cancer showed that administration of PEG-rHuMGDF raised the nadir platelet count and hastened platelet recovery to baseline levels in comparison to the placebo-treated patients.
    • (1997) N Engl J Med , vol.336 , pp. 404-409
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3    Garst, J.4    Figlin, R.5    Sheriday, W.6    Menchaca, D.7    Tomita, D.8    Ozer, H.9    Harker, L.10
  • 27
    • 17944389931 scopus 로고    scopus 로고
    • Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
    • Basser RL, Rasko J, Clarke K, Cebon J, Green MD, Grigg AP, Zalcberg J, Cohen B, O'Byrne J, Menchaca DM, et al.: Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 1997, 89:3118-3128. Patients with solid tumors being treated with a myelosuppressive chemotherapy regimen were randomly selected to receive PEG-rHuMGDF plus granulocyte colony-stimulating factor, or placebo plus granulocyte colony-stimulating factor. The addition of PEG-rHuMGDF accelerated platelet recovery to baseline values, and increased mobilization of primitive hematopoietic progenitor cells into the blood.
    • (1997) Blood , vol.89 , pp. 3118-3128
    • Basser, R.L.1    Rasko, J.2    Clarke, K.3    Cebon, J.4    Green, M.D.5    Grigg, A.P.6    Zalcberg, J.7    Cohen, B.8    O'Byrne, J.9    Menchaca, D.M.10
  • 29
    • 0030887643 scopus 로고    scopus 로고
    • Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro
    • Wun T, Paglieroni T, Hammond WP, Kaushansky K, Foster DC: Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro. Am J Hematol 1997, 54:225-232.
    • (1997) Am J Hematol , vol.54 , pp. 225-232
    • Wun, T.1    Paglieroni, T.2    Hammond, W.P.3    Kaushansky, K.4    Foster, D.C.5
  • 31
    • 0030039567 scopus 로고    scopus 로고
    • Thrombopoietin, the ligand for the Mpl receptor, synergy with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice
    • Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thrombopoietin, the ligand for the Mpl receptor, synergy with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996, 87:4544-4551.
    • (1996) Blood , vol.87 , pp. 4544-4551
    • Ku, H.1    Yonemura, Y.2    Kaushansky, K.3    Ogawa, M.4
  • 32
    • 0030014681 scopus 로고    scopus 로고
    • The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
    • Sitnicka E, Lin N, Priestley GV, Fox N, Broudy VC, Wolf NS, Kaushansky K: The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996, 87:4998-5005.
    • (1996) Blood , vol.87 , pp. 4998-5005
    • Sitnicka, E.1    Lin, N.2    Priestley, G.V.3    Fox, N.4    Broudy, V.C.5    Wolf, N.S.6    Kaushansky, K.7
  • 33
    • 0031000903 scopus 로고    scopus 로고
    • Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood
    • Piacibello W, Sanavio F, Garetto L, Severino A, Bergandi D, Ferrario J, Fagioli F, Berger M, Aglietta M: Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. Blood 1997, 89:2644-2653. Human cord blood cells were cultured in the presence of FLT3 ligand plus thrombopoietin in vitro. The numbers of CFU-GM were expanded more than 2 million fold during the 6-month culture period. If it can be demonstrated that stem cells are also expanded, this approach may eventually prove useful for cord blood transplantation programs.
    • (1997) Blood , vol.89 , pp. 2644-2653
    • Piacibello, W.1    Sanavio, F.2    Garetto, L.3    Severino, A.4    Bergandi, D.5    Ferrario, J.6    Fagioli, F.7    Berger, M.8    Aglietta, M.9
  • 34
    • 0029963122 scopus 로고    scopus 로고
    • Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multi-lineage hematopoietic reconstitution in nonhuman primates after radiation induced marrow aplasia
    • Farese AM, Hunt P, Grab LB, MacVittae TJ: Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multi-lineage hematopoietic reconstitution in nonhuman primates after radiation induced marrow aplasia. J Clin Invest 1996, 97:2145-2151.
    • (1996) J Clin Invest , vol.97 , pp. 2145-2151
    • Farese, A.M.1    Hunt, P.2    Grab, L.B.3    MacVittae, T.J.4
  • 35
    • 0029999474 scopus 로고    scopus 로고
    • Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients
    • Molineaux G, Hartley C, McElroy P, McCrea C, McNiece IK: Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients. Blood 1996, 88:366-376.
    • (1996) Blood , vol.88 , pp. 366-376
    • Molineaux, G.1    Hartley, C.2    McElroy, P.3    McCrea, C.4    McNiece, I.K.5
  • 36
    • 17144452780 scopus 로고    scopus 로고
    • Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients
    • Bertolini F, Battaglia M, Pedrazzoli P, Da Prada GA, Lanza A, Soligo D, Caneve L, Sarina B, Murphy S, Thomas T, della Cuna GR: Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients. Blood 1997, 89:2679-2688. Human C034+ peripheral blood progenitor cells were cultured in the presence of a cocktail of cytokines including thrombopoietin, then infused into patients undergoing autologous peripheral blood stem cell transplantation. The infusion of the ex vivo-generated megakaryocytes was safe. Whether this approach will decrease the need for platelet transfusions remains to be determined.
    • (1997) Blood , vol.89 , pp. 2679-2688
    • Bertolini, F.1    Battaglia, M.2    Pedrazzoli, P.3    Da Prada, G.A.4    Lanza, A.5    Soligo, D.6    Caneve, L.7    Sarina, B.8    Murphy, S.9    Thomas, T.10    Della Cuna, G.R.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.