Cytokine and chemokine production by CD34+ haemopoietic progenitor cells: Detection in single cells

British Journal of Haematology

Volumn 97, Issue 1, 1997, Pages 9-14

  Behringer, Dirk ^a   Kresin, Vera ^a   Henschler, Reinhardt ^a   Mertelsmann, Roland ^a   Lindemann, Albrecht ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

CD34+ cells; chemokine; cytokine; immunocytochemistry; single cell level

Indexed keywords

CD34 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 8; IONOMYCIN; PHORBOL ESTER; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL;

EID: 0030888729     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2143.x     Document Type: Article

References (27)

1. Andersson, J., Björk, L., Ågren, K., Litton, M. & Andersson, U. (1994) Concomitant in vivo production of 19 different cytokines in human tonsils. Immunology, 82, 16-24.
2. Andersson, J., Björk, L., Dinarello, C. & Andersson, U. (1992) Lipopolysaccharide induces human interleukin 1 receptor antagonist- and interleukin 1-production in the same cell. European Journal of Immunology, 22, 2617-2623.
3. Andersson, U., Andersson, J., Lindfors, A., Wagner, K., Möller, G. & Heusser, C. (1990) Simultaneous production of interleukin 2, interleukin 4 and interferon-gamma by activated human blood lymphocytes. European Journal of Immunology, 20, 1591-1596.
4. Behringer, D., Sunderer, B., Andersson, U., Kresin, V., Mertelsmann, R. & Lindemann, A. (1996) Simultaneous detection of cytokine and immunophenotype at the single cell level by immunoenzymatic double staining. Histochemical Journal, 28, 461-466.
5. Bot, F.J., Dorsser, L., Wagemaker, G. & Lowenberg, B. (1988) Stimulatory spectrum of human recombinant multi-CSF (IL-3) on human marrow precursors: importance of accessory cells. Blood, 71, 1609-1614.
6. Broxmeyer, H.E., Cooper, S., Hague, N., Benninger, L., Sarris, A., Cornetta, K., Vadhan-Raj, S., Hendrie, P. & Mantel, C. (1995b) Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor-dependent cell line and in vivo in mice. Annals of Hematology, 71, 235-246.
7. Broxmeyer, H.E., Cooper, S., Cacalano, G., Hague, N.L., Bailish, E. & Moore, M.W. (1995a) Interleukin-8 is a myelosuppressive regulatory cytokine in vivo: evidence from mice lacking the murine IL-8 receptor homolog. Blood, 86, (Suppl. 422a), 1675.
8. + cells and unseparated peripheral blood progenitor cells mediate identical hematopoietic engraftment after high-dose VP16, ifosfamide, carboplatin, and epirubicin. Blood, 84, 1421-1426.
9. Cacalano, G., Lee, J., Kikly, K., Ryan, A.M., Pitts-Meek, S., Hultgren, B., Wood, W.I. & Moore, M.W. (1994) Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science, 265, 682-684.
10. + progenitors. Journal of Experimental Medicine, 177, 1815-1820.
11. + hemopoietic progenitor cells. Blood, 79, 2628-2635.
12. Degliantoni, G., Murphi, M., Kobayshi, M., Francis, M.K., Perussia, B. & Trincheri, G. (1985) NK cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor: relationship with tumour necrosis factor and synergism with immune interferon. Journal of Experimental Medicine, 162, 1512-1530.
13. Dinarello, C. (1991) Interleukin-1 and interleukin-1 antagonism. Blood, 77, 1627-1652.
14. + cells into the myeloid lineage. Blood, 80, 1405-1412.
15. + hematopoietic progenitor cells towards distinct dendritic cell subsets of the Birbeck-granule and MHC-positive Langerhans cell and the interdigitating dendritic cell type. Blood, 88, 2541-2548.
16. Lindemann, A., Riedel, D., Oster, W., Ziegler-Heitbrock, H., Mertelsmann, R. & Herrmann, F (1989) Granulocyte-macrophage colony-stimulating factor induces cytokine secretion by human polymorphonuclear leucocytes. Journal of Clinical Investigation, 83, 1308-1312.
17. ++ stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum. Experimental Hematology, 21, 1442-1446.
18. Nakamura, M., Kanakura, Y., Furukawa, Y., Ernst, T.J. & Griffin, J.D. (1990) Demonstration of interleukin-1β transcripts in acute myeloblastic leukemic cells by in situ hybridization. Leukemia, 4, 466-470.
19. Oppenheim, J., Zachariae, C., Mukaida, N. & Matsushima, K. (1991) Properties of the novel proinflammartoy supergene 'integrine' family. Annual Reviews of Immunology, 9, 617-648.
20. Oster, W., Cicco, N.A., Klein, H., Hirano, T., Kishimoto, T., Lindemann, A., Mertelsmann, R.H. & Herrmann, F. (1989) Participation of the cytokines interleukin 6, tumor necrosis factor-alpha, and interleukin 1-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control. Journal of Clinical Investigation, 84, 451-457.
21. Oster, W., Lindemann, A., Mertelsmann, R. & Herrmann, F. (1988) Regulation of gene expression of M-, G-, GM-, and multi-CSF in normal and malignant hematopoietic cells. Blood Cells, 14, 443-462.
22. Sato, N., Caux, C., Kitamura, T., Watanabe, Y., Arai, K., Banchereau, J. & Miyajima, A. (1993) Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells. Blood, 82, 752-761.
23. Tobler, A., Moser, B., Dewald, B., Geiser, T., Studer, H., Baggiolini, M. & Fey, M.F. (1993) Constitutive expression of interleukin-8 and its receptor in human myeloid and lymphoid leukemia. Blood, 82, 2517-2525.
24. Vassalli, P. (1992) The pathophysiology of tumor necrosis factors. Annual Reviews of Immunology, 10, 411-452.
25. Watari, K., Lansdorp, P.M., Dragowdka, W., Mayani, H. & Schrader, J.W. (1994) Expression of interleukin-1β gene in candidate human hematopoietic stem cells. Blood, 84, 36-43.
26. Watari, K., Mayani, H., Lee, F., Dragowska, W., Lansdorp, P.M. & Schrader, J.W. (1996) Production of interleukin 1-β by human hematopoietic progenitor cells. Journal of Clinical Investigation, 97, 1666-674.
27. Young, D.C. & Griffin, J.D. (1986) Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood, 68, 1178-1781.