Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro

Cancer Research

Volumn 61, Issue 10, 2001, Pages 3978-3985

  Penate Medina, O ^a   Soderlund T ^a   Laakkonen, L J ^a   Tuominen, E K J ^a   Koivunen, E ^b   Kinnunen, P K J ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; CYSTEINYLTHREONYLTHREONYLHISTIDYLTRYPTOPHYLGLYCYLPHENYLALANYLTHREONYLLEUCYL CYSTEINE; DOXORUBICIN; GELATINASE INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG TARGETING; DRUG UPTAKE; FLUORESCENCE ANALYSIS; HUMAN; LEUKEMIA CELL; MEMBRANE BINDING; NONHUMAN; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; SARCOMA CELL;

ANIMALS; CHO CELLS; CRICETINAE; ENZYME INHIBITORS; HUMANS; LIPOSOMES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PHOSPHOLIPIDS; U937 CELLS;

EID: 0035872407     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Cancer therapy with a novel tumor-targeting gelatinase inhibitor selected by phage peptide display
2. Mighty mice: Transgenic technology "knocks out" questions of matrix metalloproteinase function
3. The degradation of type II collagen in rheumatoid arthritis: An immunoelectron microscopic study
4. Proteolytic remodeling of extracellular matrix
5. Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages
6. Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl) mercuric acetate
7. Tumor cell interactions with the extracellular matrix during invasion and metastasis
8. Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor
9. Reversal of experimental autoimmune encephalomyelitis with a hydroxomate inhibitor of matrix metalloproteases
10. Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases
11. Doubleblind, placebo-controlled study of the three month treatment with lymecyclinein reactive arthritis, with special reference to Chlamydia arthritis
12. Transmembrane gradient driven phase transitions within vesicles: Lessons for drug delivery
13. Liposomal doxorubicin
14. Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: Pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma
15. Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice
16. Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity
17. Biosynthetically lipid-modified human scFv fragments from phage display libraries as targeting molecules for immunoliposomes
18. Immunotargeting of liposomes to activated vascular endothelial cells: A strategy for site-selective delivery in the cardiovascular system
19. Liposomes: Quo vadis?
20. Control of type IV collagenase activity by components of the urokinase-plasmin system: A regulatory mechanism with cell-bound reactants
21. Phorbol ester-induced cell surface association of matrix metalloproteinase-9 in human MCF10A breast epithelial cells
22. 3
23. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
24. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
25. Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1
26. Tissue inhibitor of metalloproteinases-1 (TIMP-1) binds to the cell surface and translocates to the nucleus of human MCF-7 breast carcinoma cells
27. Basic local alignment search tool
28. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
29. Identification of protein coding regions by database similarity search
30. Applications of network BLAST server
31. Synthesis of a mixture of cyclic peptides based on the Bowman-Birk reactive site loop to screen for serine protease inhibitors
32. Characterization of matrix metalloproteinase (MMP-8 and -9) activities in the saliva and in gingival crevicular fluid of children with Down's syndrome
33. Activation of type IV procollagenases by human tumor-associated trypsin-2
34. Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant
35. Lipid monolayers: Why use half a membrane to characterize protein-membrane interactions?
36. Factors affecting solute entrapment in phospholipid vesicles prepared by the freeze-thaw extrusion method: A possible general method for improving the efficiency of entrapment
37. Small-volume extrusion apparatus for preparation of large, unilamellar vesicles
38. Use of resonance energy transfer to monitor membrane fusion
39. Novel cell permeable motif derived from the PreS2-domain of hepatitis-B virus surface antigens
40. An improved fluorescence assay for the determination of lymphocyte-mediated cytotoxicity using flow cytometry
41. Adsorption of vitamin K-dependent blood coagulation proteins to spread phospholipid monolayers as determined from combined measurements of the surface pressure and surface protein concentration
42. Interactions of cyclosporin A with phospholipid membranes: Effect of cholesterol
43. Effects of cationic and hydrophobic peptide, KL4, on model lung surfactant lipid monolayers
44. How colipase-fatty acid interactions mediate adsorption of pancreatic lipase to interfaces
45. pH-dependent membrane fusion and vesiculation of phospholipid large unilamellar vesicles induced by amphiphilic anionic and cationic peptides
46. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages
47. An improved method of encapsulation of doxorubicin in liposomes: Pharmacological, toxicological and therapeutic evaluation
48. Matrix metalloproteinase inhibition: A review of antitumour activity
49. Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells
50. Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin
51. Computational sequence analysis of matrix metalloproteinases
52. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
53. Attachment of antibodies to sterically stabilized liposomes: Evaluation, comparison and optimization of coupling procedures