Interactions of cyclosporin A with phospholipid membranes: Effect of cholesterol

Molecular Pharmacology

Volumn 55, Issue 1, 1999, Pages 32-38

  Söderlund, Tim ^a   Lehtonen, Jukka Y A ^a   Kinnunen, Paavo K J ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLOSPORIN A; DIMYRISTOYLPHOSPHATIDYLCHOLINE; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PHOSPHORYLCHOLINE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; FLUORESCENCE MICROSCOPY; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL;

EID: 0038101243     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.1.32     Document Type: Article

References (39)

1. Bechinger B (1997) Structure and functions of channel-forming peptides: Magainins, cecropins, mellitin and alamethicin. J Membr Biol 156:197-211.
2. Bernardi P (1996) The permeability transition pore: Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death. Biochim Biophys Acta 1275:5-9.
3. Cohen DJ, Loertscher R, Rubin MF, Tilney NL, Carpenter CB and Strom TB (1984) Cyclosporine: A new immunosuppressive agent for organ transplantation. Ann Intern Med 101:667-682.
4. Demel RA and de Kruyff B (1976) The function of sterols in membranes. Biochim Biophys Acta 457:109-132.
5. de-Paula E and Schreier S (1996) Molecular and physicochemical aspects of local anesthetic-membrane interaction. Brazilian J Med Biol Res 29:877-894.
6. 2+-induced lateral phase separation in phosphatidic acid/phosphatidylcholine monolayers as revealed by fluorescence microscopy. Biochemistry 27:3433-3437.
7. Epand RM, Epand RF and McKenzie RC (1987) Effects of viral chemotherapeutic agents on membrane properties: Studies of cyclosporin A, benzyloxycarbonyl-D-Phe-L-Phe-Gly and amantadine. J Biol Chem 262:1526-1529.
8. Gershfeld NL and Pagano RE (1972) Physical chemistry of lipid films at the air-water interface. III. The condensing effect of cholesterol: A critical examination of mixed-film studies. J Physiol Chem 76:1244-1249.
9. Goormaghtigh E, Brasseur R and Ruysschaert JM (1982) Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment. Biochim Biophys Res Commun 104:314-320.
10. 2 in phosphatidylcholine monolayers. FEBS Lett 252:73-82.
11. Hemar A and Dautry-Varsat A (1990) Cyclosporin A inhibits the interleukin 2 receptor alpha chain gene transcription but not its cell surface expression: The alpha chain stability can explain this discrepancy. Eur J Immunol 20:2629-2635.
12. Ipsen JH, Karlström G, Mouritsen OG, Wennerström H and Zuckermann MJ (1987) Phase equilibria in the phosphatidylcholine-cholesterol system. Biochim Biophys Acta 905:162-172.
13. Ito S, Werth DK, Richert ND and Pastan I (1983) Vinculin phosphorylation by the src kinase: Intercation of vinculin with phospholipid vesicles. J Biol Chem 258:14626-14631.
14. Jutila A and Kinnunen PKJ (1997) Novel features of the main transition of dimyristoylphosphocholine bilayers revealed by fluorescence spectroscopy. J Phys Chem 101:7635-7640.
15. Jutila A, Rytömaa M and Kinnunen PKJ (1998) Detachment of cytochrome c by cationic drugs from membranes containing acidic phospholipids: Comparison of lidocaine, propranolol, and gentamycin. Mol Pharmacol, 54:722-732.
16. Kitagaki K, Nagai H, Hayashi S and Totsuka T (1997) Facilitation of apoptosis by cyclosporins A and H, but not FK506 in mouse bronchial eosinophils. Eur J Pharmacol 337:283-289.
17. Kinnunen PKJ (1991) On the principles of functional ordering in biological membranes. Chem Phys Lipids 57:375-399.
18. Kinnunen PKJ (1996) On the molecular-level mechanisms of peripheral protein-membrane interactions induced by lipids forming inverted non-lamellar phases. Chem Phys Lipids 81:151-166.
19. Kinnunen PKJ and Laggner P, eds (1991) Phospholipid phase transitions. Chem Phys Lipids 57:109-399.
20. Kopp JB and Klotman PE (1990) Cellular and molecular mechanisms of cyclosporin nephrotoxicity. J Am Soc Nephr 1:162-179.
21. Lance MR, Washington C and Davis SS (1996) Evidence for the formation of amphotericin B-phosphotipid complexes in Langmuir monolayers. Pharmaceut Res 13:1008-1014.
22. Lee KYC, Klinger JF and McConnell HM (1994) Electric field-induced concentration gradients in lipid monolayers. Science (Wash DC) 263:655-658.
23. Lehtonen JYA, Rytömaa M and Kinnunen PKJ (1996) Characteristics of the binding of tacrine to acidic phospholipids. Biophys J 70:2185-2194.
24. Liu F, Sugar IP and Chong PLG (1997) Cholesterol and ergosterol superlattices in three-component liquid crystalline lipid bilayers as revealed by dehydroergosterol fluorescence. Biophys J 72:2243-2254.
25. McMullen TPW, Lewis RNAH and McElhaney RN (1993) Differential scanning calorimetric studies of the effect of cholesterol on the thermotropic phase behavior of a homologous series of linear saturated phosphatidylcholines. Biochemistry 32:516-522.
26. Mouritsen OG and Kinnunen PKJ (1996) Role of lipid organization and dynamics for membrane functionality, in Biological Membranes (Merz K Jr and Roux B eds) pp 463-502, Birkhäuser, Boston.
27. 2 by adriamycin in vitro: Role of drug/lipid interactions. J Biol Chem 266:6302-6307.
28. 2. Biochemistry 32:5373-5380.
29. Mustonen P, Virtanen JA, Somerharju PJ and Kinnunen PKJ (1987) Binding of cytochrome c to liposomes as revealed by the quenching of fluorescence from pyrene-labelled phospholipids. Biochemistry 26:2991-2997.
30. Nag K, Boland C, Rich N and Keough KMW (1991) Epifluorescence microscopic observation of monolayers of dipalmitoylphosphatidylcholine: Dependence of domain size on compression rates. Biochim Biophys Acta 1068:157-160.
31. O'Donohue MF, Burgess AW, Walkinshaw MD and Treutlein HR (1995) Modeling conformational changes in cyclosporin A. Prot Sci 4:2191-2202.
32. O'Leary TJ, Ross PD, Lieber MR and Levin IW (1986) Effects of cyclosporine A on biomembranes: Vibrational spectroscopic, calorimetric and hemolysis studies. Biophys J 49:795-801.
33. Rytömaa M and Kinnunen PKJ (1996) Dissociation of cytochrome c from liposomes by historine H1: Comparison with basic peptides. Biochemistry 35:4529-4539.
34. Schroeder F, Woodford JK, Kavecansky J, Wood WG and Joiner C (1995) Cholesterol domains in biological membranes. Mol Memor Biol 12:113-119.
35. Söderlund T, Jutila A and Kinnunen PKJ (1999) Binding of adriamycin to liposomes as a probe for membrane lateral organization. Biophys J In Press.
36. Subirade M, Salesse C, Marion D and Pezolet M (1995) Interaction of a nonspecific wheat lipid transfer protein with phospholipid monolayers imaged by fluorescence microscopy and studied by infrared spectroscopy. Biophys J 69:974-988.
37. Weis RM (1991) Fluorescence microscopy of phospholipid monolayer phase transitions. Chem Phys Lipids 57:227-239.
38. Weis RM and McConnell HM (1985) Cholesterol stabilizes the crystal-liquid interface in phospholipid monolayers. J Physiol Chem 89:4453-4459.
39. Wiedmann TS, Trouard T, Shekar SC, Polikandritou M and Rahman YE (1990) Interaction of cyclosporin A with dipalmitoylphosphatidylcholine. Biochim Biophys Acta 1023:12-18.