Structural dynamics of oligodendrocyte lysis by perforin in culture: Relevance to multiple sclerosis

Journal of Neuroscience Research

Volumn 64, Issue 4, 2001, Pages 380-391

  Zeine, Rana ^a   Cammer, Wendy ^a   Barbarese, Elisa ^b   Liu, Chau Ching ^a   Raine, Cedric S ^c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; Cytotoxicity; Demyelination; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Oligodendrocyte; Perforin

Indexed keywords

PERFORIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DEMYELINATING DISEASE; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL CULTURE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; FEMALE; MEMBRANE GLYCOPROTEINS; MICE; MULTIPLE SCLEROSIS; OLIGODENDROGLIA; PORE FORMING CYTOTOXIC PROTEINS; VACUOLES;

EID: 0035872283     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1089     Document Type: Article

References (69)

1. Non-MHC-restricted cell-mediated lysis of human oligodendrocytes in vitro: Relation with CD56 expression
2. Spatial distribution of myelin basic protein mRNA and polypeptide in quaking oligodendrocytes in culture
3. Morphological organization of oligodendrocyte processes during development in culture and in vivo
4. Gamma delta T cell receptor analysis supports a role for HSP 70 selection of lymphocytes in multiple sclerosis lesions
5. Cell death during autoimmune demyelination: Effector but not target-cells are eliminated by apoptosis
6. Multiple sclerosis: Oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis
7. Mechanisms of immune injury in multiple sclerosis
8. Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse
9. Adoptively-transferred acute and chronic relapsing autoimmune encephalomyelitis in the PL/J mouse with observations on altered pathology by intercurrent infection
10. Multiple sclerosis: Fas signaling in oligodendrocyte cell death
11. Lymphocytes from mice chronically infected with Theiler's murine encephalomyelitis virus produce demyelination of organotypic cultures after stimulation with the major encephalitogenic epitope of myelin proteolipid protein. Epitope spreading in TMEV infection has functional activity
12. Examination of multiple sclerosis biopsy specimen
13. Perforin lytic activity is controlled by calreticulin
14. Peripheral blood gamma-delta T-cells lyse fresh human brain-derived oligodendrocytes
15. Identification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense
16. Identification of autoantibodies associated with myelin damage in multiple sclerosis
17. Perforin and tumor necrosis factor alpha in the pathogenesis of experimental allergic encephalomyelitis: Comparison of autoantigen induced and transferred disease in Lewis rats
18. Resistance of cytolytic lymphocytes to perforin-mediated killing. Inhibition of perforin binding activity by surface membrane proteins
19. 2+ changes in individual oligodendrocytes attacked by T-cell perforin
20. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
21. The role of activated cytotoxic T-cells in inflammatory bowel disease
22. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity
23. Pseudoviral hollow-cored vesicles in multiple sclerosis brain
24. High numbers of perforin mRNA expressing CSF cells in multiple sclerosis patients with gadolinium-enhancing brain MRI lesions
25. Multiple sclerosis: A role for astroglia in active demyelination suggested by Class II MHC expression and uttrastructural study
26. Perforin and lymphocytemediated cytolysis
27. Perforin: Structure and function
28. Lymphocyte-mediated cytolysis and disease
29. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
30. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases
31. The pathobiology of the oligodendrocyte
32. Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice
33. Role of natural killer cells and TCR gamma delta T-cells in acute autoimmune encephalomyelitis
34. Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis
35. Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease
36. Perforin-dependent neurologic injury in a viral model of multiple sclerosis
37. The long term culture of bulk-isolated bovine oligodendroglia from adult brain
38. Resistance to the pore-forming protein of cytotoxic T-cells: Comparison of target cell membrane rigidity
39. Plasma membrane-associated proteins with the ability to partially inhibit perforin-mediated lysis
40. Cytolytic and ion channel-fonning properties of the N terminus of lymphocyte perforin
41. Expression of the T cell receptor delta-chain repertoire in mouse lymph node
42. Electron microscopic features of multiple sclerosis lesions
43. Multiple sclerosis and central nervous system demyelination
44. The neuropathology of multiple sclerosis
45. Demyelinating diseases
46. Biology of disease. Analysis of autoimmune demyelination: Its impact upon multiple sclerosis
47. The lesion in multiple sclerosis and chronic relapsing allergic encephalomyelitis - A structural comparison
48. The Norton lecture: A review of the oligodendrocyte in the multiple sclerosis lesion
49. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigen-specific antibody mediation
50. A pathogenic role for gamma delta T-cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse
51. Ultrastructure of multiple sclerosis
52. Oligodendrocyte injury is an early event in lesions of multiple sclerosis
53. Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes
54. Serum cytotoxicity to human and rat oligodendrocytes in culture
55. Reversible injury of cultured rat oligodendrocytes by complement
56. Oligodendrocyte susceptibility to injury by T-cell perforin
57. Complement mediated serum cytotoxicity against oligodendrocytes: A comparison with other cells of the oligodendrocyte-type 2 astrocyte lineage
58. Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis
59. Non-specific oligodendrocyte cytotoxicity mediated by soluble products of activated T-cell lines
60. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
61. Oligodendroglia are protected from antibody-mediated complement injury by normal immunoglobulins (IVIg)
62. Ultrastructural studies of multiple sclerosis
63. 2+-dependent receptor molecule for lymphocyte perforin
64. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis
65. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perforin and granzyme B mobilization by functional ERK2
66. Human oligodendrocytes are not sensitive to complement. A study of CD59 expression in the human central nervous system
67. Perforin expression in demyelinative lesions of multiple sclerosis, and a role for perforin in the regulation of experimental autoimmune encephalomyelitis
68. Mechanism of gamma delta T cell-induced human oligodendrocyte cytotoxicity: Relevance to multiple sclerosis
69. Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells