S-adenosylmethionine protects against cyclosporin A-induced alterations in rat liver plasma membrane fluidity and functions

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 774-781

  Galán, Ana I ^a   Muñoz, M Eugenia ^a   Jiménez, Rafael ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CYCLOSPORIN A; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIVER ENZYME; LIVER PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; S ADENOSYLMETHIONINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; BLOOD; CELL MEMBRANE FLUIDITY; CHOLESTASIS; CONTROLLED STUDY; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER CELL MEMBRANE; LIVER PROTECTION; LIVER TOXICITY; MALE; MEMBRANE VESICLE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANESTHESIA; ANIMALS; BILE; BILE DUCTS; BLOOD FLOW VELOCITY; CELL MEMBRANE; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; LIVER; LIVER FUNCTION TESTS; MALE; MEMBRANE FLUIDITY; OXIDATIVE STRESS; PHOSPHOLIPIDS; PROTEINS; RANDOM ALLOCATION; RATS; RATS, WISTAR; S-ADENOSYLMETHIONINE;

EID: 0345279873     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Alvaro D, Gigliozzi A, Piat C, Carli L, Bini A, La Rosa T, Furfaro S and Capocaccia L (1995) Effect of S-adenosyl-L-methionine on ethanol cholestasis and hepatotoxicity in isolated perfused rat liver. Dig Dis Sci 40:1592-1600.
2. Arrese M, Pizarro M, Soils N, Koenig C and Accatino L (1995) Enhanced biliary excretion of canalicular membrane enzymes in ethynylestradiol-induced cholestasis: Effects of ursodeoxycholic acid administration. Biochem Pharmacol 50:1223-1232.
3. Aruoma OI (1998) Free radicals, oxidative stress and antioxidants in human health and disease. J Am Oil Chem Soc 75:199-212.
4. Avogaro P, Cazzolato G, Quinci GB and Bittolo Bon G (1979) Variations of plasma apolipoproteins AI and B induced in liver patients by infusions S-adenosyl-L-methionine. Pharmacol Res Commun 11:681-691.
5. Bäckman L, Appelkvist EL, Brunk U and Dallner G (1986) Influence of cyclosporin A treatment on intracellular membranes of hepatocytes. Exp Mol Pathol 45:31-43.
6. Bäckman L, Appelkvist EL and Dallner G (1988) Influence of cyclosporine A on protein synthesis in rat liver. Exp Mol Pathol 49:38-49.
7. Barth SA, Inselmann G, Engemann R and Heidemann HT (1991) Influences of Ginkgo biloba on cyclosporin A induced lipid peroxidation in human liver microsomes in comparison to vitamin E, glutathione and N-acetylcysteine. Biochem Pharmacol 41:1521-1526.
8. +-ATPaSe, membrane fluidity, and bile flow in rats with ethinylestradiol-induced cholestasis. Hepatology 3:12-17.
9. Böhme M, Muller M, Leier I, Jedlitschky G and Keppler D (1994) Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107:255-265.
10. Bontemps F and Van Den Berghe G (1998) Novel evidence for an ecto-phospholipid methyltransferase in isolated rat hepatocytes. Biochem J 330:1-4.
11. Bossard R, Stieger B, O'Neill B, Fricker G and Meier PJ (1993) Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver. J Clin Invest 91:2714-2720.
12. Bray GP, Tredger JM and Williams R (1992) S-Adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models. Hepatology 15:297-301.
13. Chagoya De Sánchez V, Hernández-Muñoz R, Sánchez L, Vidrio S, Yáñez L and Suárez J (1991) Twenty-four-hour changes of s-adenosylmethionine, s-adenosylhomocysteine adenosine and their metabolizing enzymes in rat liver: Possible physiological significance in phospholipid methylation. Int J Biochem 23:1439-1443.
14. Chan FKL, Zhang Y, Lee SS and Shaffer EA (1998) The effects of liver transplantation and cyclosporine on bile formation and lipid composition: An experimental study in the rat. J Hepatol 28:329-336.
15. Corrales F, Giménez A, Álvarez L, Caballería J, Pajares MA, Andreu H, Parés A, Mato JM and Rodés J (1992) S-Adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury. Hepatology 16:1022-1027.
16. Corrales F, Ochoa P, Rivas C, Martín-Lomas M, Mato JM and Pajares MA (1991) Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction. Hepatology 14:528-533.
17. Deters M, Strubelt O and Younes M (1997) Reevaluation of cyclosporine induced hepatotoxicity in the isolated perfused rat liver. Toxicology 123:197-206.
18. Faulds D, Goa KL and Benfield P (1993) Cyclosporin: A review of its pharmacodynamic and pharmacokinetics properties, and therapeutic use in inmunoregulatory disorders. Drugs 45:953-1040.
19. Fee F, Pascale R, Garcea R, Daino L, Pirisi L, Frassetto S, Ruggiu ME, Di Padova C and Stramentinoli G (1986) Effect of the variations of S-adenosyl-L-methionine liver content on fat accumulation and ethanol metabolism in ethanol-intoxicated rats. Toxicol Appl Pharmacol 83:331-341.
20. Fernández E, Galán AI, Morán D, González-Buitrago JM, Muñoz ME and Jiménez R (1995) Reversal of cyclosporine A-induced alterations in biliary secretion S-adenosyl-L-methionine in rats. J Pharmacol Exp Ther 275:442-449.
21. Folch J, Lees M and Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509.
22. Fricker G, Landmann L and Meier PJ (1988) Ethinylestradiol (EE) induced structural and functional alterations of rat liver plasma membranes and their reversal by S-adenosylmethionine (SAMe) in vitro (Abstract) Hepatology 8:1224.
23. Friedel HA, Goa KL and Benfield P (1989) S-Adenosyl-L-methionine: A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 38:389-416.
24. Galán AI, Fernández E, Morán D, Muñoz ME and Jiménez R (1995) Cyclosporine A hepatotoxicity: Effect of prolonged treatment with cyclosporine on biliary lipid secretion in the rat. Clin Exp Pharmacol Physiol 22:260-265.
25. Galán AI, Román ID, Muñoz ME, Cava F, González-Buitrago JM, Esteller A and Jiménez R (1992) Inhibition of biliary lipid and protein secretion by cyclosporine A in the rat. Biochem Pharmacol 44:1105-1113.
26. Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106:207-212.
27. Hirata F and Axerold J (1980) Phospholipid methylation and biological signal transmission. Science 209:1082-1090.
28. Jiménez R, Morán D, Galán AI, Fernández E, Felipe A, Moyano C and Muñoz ME (1996) Effect of exogenous S-adenosyl-L-methionine on cyclosporine A-induced alterations in biliary and hepatic glutathione (Abstract). Hepatology 24:528A.
29. Kaplowitz N and Tsukamato H (1996) Oxidative stress and liver disease. Prog Liver Dis 14:131-159.
30. 2+. Biochim Biophys Acta 413:143-156.
31. Kukongviriyapan V and Stacey NH (1991) Chemical-induced interference with hepatocellular transport: Role in cholestasis. Chem-Biol Interact 77:245-261.
32. Lieber CS (1997) Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Adv Pharmacol 38:601-628.
33. Loss M, Winkler M, Schneider A, Brinkmann C, Manns M, Ringe B and Pichimayr R (1995) Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. Transplant Proc 27:1136-1139.
34. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
35. Lu SC (1998) Methionine adenosyltransferase and liver disease: It's all about SAM. Gastroenterology 114:403-407.
36. Mato JM (1986) Regulation of phospholipid methylation and its effect on membrane proteins, in Progress in Protein-Lipid Interactions (Watts A and De Pont JJ eds) vol 2, pp 267-302, Elsevier Scientific, New York.
37. Mato JM, Álvarez L, Corrales FJ and Pajares MA (1994) S-Adenosylmethionine and the liver, in The Liver: Biology and Pathobiology, 3rd ed (Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA and Shafritz DA eds) pp 461-470, Raven Press, New York.
38. Mato JM, Álvarez L, Ortiz P and Pajares MA (1997) S-Adenosylmethionine synthesis: Molecular mechanisms and clinical implications. Pharmacol Ther 73:265-280.
39. Morán D, Galán AI, Fernández E, Moreno C, Jiménez R and Muñoz ME (1996) Increases in lipid peroxidation in rats chronically treated with cyclosporine. J Physiol (Lond) 493 P:114S.
40. Morán D, González-Buitrago JM, Fernández E, Galán AI, Muńoz ME and Jiménez R (1998) Inhibition of biliary glutathione secretion by cyclosporine A in the rat: Possible mechanisms and role in the cholestasis induced by the drug. J Hepatol 29:68-77.
41. Moseley RH, Johnson TR and Morrissette JM (1990) Inhibition of bile acid transport by cyclosporine A in rat liver plasma membrane vesicles. J Pharmacol Exp Ther 253:974-980.
42. Muriel P and Mourelle M (1992) Characterization of membrane fraction lipid composition and function of cirrhotic rat liver: Role of S-adenosyl-L-methionine. J Hepatol 14:16-21.
43. Ohkawa H, Ohishi N and Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Ann Biochem 95:351-358.
44. Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK and Groothuis GMM (1995) Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
45. +)ATPase: Protective effect of S-adenosyl-L-methionine, L-methionine, and N-acetylcysteine. Toxicol Appl Pharmacol 97:216-229.
46. Pisi E and Marchesini G (1990) Mechanisms and consequences of the impaired trans-sulphuration pathway in liver disease: Part II. Clinical consequences and potential for pharmacological intervention in cirrhosis. Drugs 40 (Suppl 3):65-72.
47. Román ID, Monte MJ, González Buitrago JM, Esteller A and Jiménez R (1990) Inhibition of hepatocytary vesicular transport by cyclosporin A in the rat: Relationship with cholestasis and hyperbilirubinemia. Hepatology 12:83-91.
48. Rosario J, Sutherland E, Zaccaro L and Simon FR (1988) Ethinylestradiol administration selectively alters liver sinusoidal membrane lipid fluidity and protein composition. Biochemistry 27:3939-3946.
49. Schramm U, Wolf A, Dubost V, Kurz G and Fricker G (1993) Hepatic effects of cyclosporins in rat liver (Abstract). Hepatology 18:302A.
50. Shinitzky M and Barenholz Y (1978) Fluidity parameters of lipid regions determined by fluorescence polarization. Biochim Biophys Acta 515:367-394.
51. Simon FR (1993) Role of membrane lipids and fluidity in hepatic plasma membrane transport processes, in Hepatic Transport and Bile Secretion: Physiology and Pathophysiology (Tavoloni N and Berk PD eds) pp 297-312, Raven Press, New York.
52. Smith DJ and Gordon ER (1987) Membrane fluidity and cholestasis. J Hepatol 5:362-365.
53. Stramentinoli G (1987) Pharmacological aspects of S-adenosylmethionine: Pharmacokinetics and pharmacodynamics. Am J Med 83:35-42.
54. Sundari PN and Ramakrishna B (1997) Does oxidative protein damage play a role in the pathogenesis of carbon tetrachloride-induced liver injury in the rat? Biochim Biophys Acta 1362:169-176.
55. + transport in rat liver. Biochem Pharmacol 46:1207-1215.
56. Torres AM, Galán AI and Tiribelli C (1994) Competition of bile acids on the sulfobromophthalein uptake in basolateral rat liver plasma membrane vesicles. Biochem Pharmacol 48:1301-1304.
57. Van Amelsvoort JMM, Sips HJ and Van Dam K (1978) Sodium-dependent alanine transport in plasma-membrane vesicles from rat liver. Biochem J 174:1083-1086.
58. Vendemiale G, Grattagliano I, Signorile A and Altomare E (1998) Ethanol-induced changes of intracellular thiol compartmentation and protein redox status in the rat liver: Effect of tauroursodeoxycholate. J Hepatol 28:46-53.
59. Verkade HJ, Vonk RJ and Kuipers F (1995) New insights into the mechanism of bile acid-induced biliary lipid secretion. Hepatology 21:1174-1189.
60. Whitington PF, Dudeja P, Hecht JR, Whitington SH and Brasitus TA (1988) Lipid alterations in the hepatocyte basolateral sinusoidal membrane (BLM) domain may explain cyclosporine (CsA) induced cholestasis in the rat (Abstract). Hepatology 8:1363.
61. Wolf A, Trendelenburg CF, Diez-Fernández C, Prieto P, Houy S, Trommer WE and Cordier A (1997) Cyclosporine A-induced oxidative stress in rat hepatocytes. J Pharmacol Exp Ther 280:1328-1334.
62. Wu J, Söderbergh H, Karlsson K and Danielsson Ȧ (1996) Protective effect of S-adenosyl-L-methionine on bromobenzene- and D-galactosamine-induced toxicity to isolated rat hepatocytes. Hepatology 23:359-365.
63. 3H]cyclosporin-diaziridine. Biochim Biophys Acta 855:147-156.
64. +-dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles. J Pharmacol Exp Ther 250:301-308.