Bag-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway

Experimental Cell Research

Volumn 265, Issue 1, 2001, Pages 167-173

  Witcher, Michael ^a   Yang, Xiaolong ^a   Pater, Alan ^a   Tang, Shou Ching ^a,b  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b Dr H Bliss Murphy Cancer Center   (Canada)

Author keywords

BAG 1 p50 isoform; Binding; Cell growth; U87 glioblastoma cells; Vitamin D receptor; Vitamin D3

Indexed keywords

CALCITRIOL; GLUCOCORTICOID RECEPTOR; GLUTATHIONE TRANSFERASE; ISOPROTEIN; PROTEIN BAG 1 P29; PROTEIN BAG 1 P33; PROTEIN BAG 1 P46; PROTEIN BAG 1 P50; PROTEIN P50; STEROID RECEPTOR; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER; CELL GROWTH; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; HUMAN; HUMAN CELL; KIDNEY FAILURE; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PSORIASIS; WESTERN BLOTTING;

EID: 0035870119     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5176     Document Type: Article

References (53)

1. Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer
2. Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues
3. Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells
4. Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors
5. Cloning and characterization of the human BAG-1 gene promoter: Upregulation by tumor-derived p53 mutants
6. Expression of BAG-1 in invasive breast carcinoma
7. A protein that interacts with members of the nuclear hormone receptor family: Identification and cDNA cloning
8. BAG-1L protein enhances androgen receptor function
9. Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells
10. RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis
11. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1
12. Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity
13. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death
14. Vitamin D receptor interacts with DnaK/heat shock protein 70: Identification of DnaK interaction site on vitamin D receptor
15. Rationale for treatment of involutional osteoporosis in women and for prevention and treatment of corticosteroid-induced osteoporosis with alfacalcidol
16. 3-deprived rats
17. Decrease in serum immunoreactive parathyroid hormone in rats and in parathyroid hormone secretion in vitro by 1,25-dihydroxycholecalciferol
18. 3: A novel immunoregulatory hormone
19. 3
20. 3
21. 3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation
22. 3-resistant variant
23. Effects of vitamin D and retinoic acid on human glioblastoma cell lines
24. Proliferation is the main epidermal target in the treatment of psoriatic plaques with once daily application of tacalciol ointment
25. Medical management of secondary hyperparathyroidism in uremia
26. The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer
27. 3 leads to the induced differentiation of the myelomonocytic cell line U937
28. Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer
29. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
30. Vitamin D
31. Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription
32. High-efficiency transformation of mammalian cells by plasmid DNA
33. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax
34. Distinct classes of transcription activating domains function by different mechanisms
35. Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells
36. Ligand occupancy is not required for vitamin D receptor and retinoid receptor-mediated transcriptional activation
37. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
38. Growth inhibition and differentiation induction in human monoblastic leukaemia cells by 1α-hydroxyvitamin D derivatives and their enhancement by combination with hydroxyurea
39. 3, transforming growth factor β1, calcium, and ultraviolet B radiation induce apoptosis in cultured human keratinocytes
40. 3 results from ligand-induced stabilization
41. Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems
42. 3 in cultured human keratinocytes
43. 3 receptor in HL-60 cells and related subclones
44. 3 regulates the expression of VDR and NGF gene in Schwann cells in vitro
45. Association of breast cancer progression with a vitamin D receptor gene polymorphism
46. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation
47. A nuclear action of the eukaryotic cochaperone RAP46 in down-regulation of glucocorticoid receptor activity
48. Eukaryotic transcription factors
49. Structure and specificity of nuclear receptor-coactivator interactions
50. The high mobility group protein 1 enhances binding of the estrogen receptor DNA binding domain to the estrogen response element
51. Nuclear receptor/AP-1 interaction
52. Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2
53. BAGL enhances trans-activation function of the vitamin D receptor