A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity

Journal of Cell Biology

Volumn 146, Issue 5, 1999, Pages 929-940

  Schneikert, Jean ^a   Hübner, Susanne ^a   Martin, Elke ^a   Cato, Andrew C B ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

BAG 1 isoforms; Cochaperone; Glucocorticoid receptor; Mineralocorticoid receptor; Transactivation

Indexed keywords

CHAPERONE; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 70; MINERALOCORTICOID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN MCF 7; DOWN REGULATION; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; KIDNEY CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION;

ANIMALIA; EUKARYOTA;

EID: 0344200100     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.146.5.929     Document Type: Article

References (49)

1. Arriza, J.L. 1991. Aldosterone action: perspectives from the cloning of the mineralocorticoid receptor. In Aldosterone. Fundamental Aspects. J.P. Bonvalet. N. Farmann, M. Lombès, and M.-E. Rafestin-Oblin, editors. John Libbey Eurotext Ltd., Paris. 13-21.
2. Arriza, J.L., C. Weinherger, G. Cerelli, T.M. Glaser, B.L. Hendelin, D.E. Housmann, and R.M. Evans. 1987. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science. 237:268-273.
3. Bardelli, A., P. Longati, D. Albero, S. Goruppi, C. Schneider, C. Ponzetto, and P.M. Comoglio. 1996. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO (Eur. Mol. Biol. Organ.) J. 15: 6205-6212.
4. Beato, M., P. Herrlich, and G. Schütz. 1995. Steroid hormone receptors: many actors in search of a plot. Cell. 83:851-857.
5. Bruner, K.L., A. Derfoul, N.M. Robertson, G. Guerriero, T. Fernandes-Alnemri, E.S. Alnemri, and G. Litwack. 1997. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. Recept. Signal Transduct. 7:85-98.
6. Bukau, B., and A.L. Horwich. 1998. The hsp70 and hsp60 chaperone machines. Cell. 92:351-366.
7. Burns, L., B. Duggan, E.A. Atkinson, S. Famulski, R.C. Nemer, R.C. Bleackley, and M. Michalak. 1994. Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature. 367:476-480.
8. Carey, K.L., S.A. Richards, K.M. Lounsbury, and I.G. Macara. 1996. Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the RAN/TC4 GTPase mediates an essential function independent of nuclear protein import. J. Cell Biol. 133:985-996.
9. Cato, A.C.B., and E. Wade. 1996. Molecular mechanisms of anti-inflammatory action of glucocorticoids. BioEssays. 18:371-378.
10. Cato, A.C.B., R. Miksicek, G. Schütz, J. Arnemann, and M. Beato. 1986. The hormone regulatory element of mouse mammary tumor virus mediates progesterone induction. EMBO (Eur. Mol. Biol. Organ.) J. 5:2237-2240.
11. Crabtree, G.R., C.D. Bloomfield, K.A. Smith, B.A. McKenna, B.A. Peterson, L. Hildebrandt, and A. Munck. 1981. Glucocorticoid receptors and in vitro responses to glucocorticoid in acute nonlymphocytic leukemia. Cancer Res. 41:4853-4856.
12. Diehl, E.E., and T.J. Schmidt. 1993. Heat shock protein 70 is associated in substoichiometric amounts with the rat hepatic glucocorticoid receptor. Biochemistry. 32:13510-13515.
13. Dittmar, K.D., and W.B. Pratt. 1997. Folding of the glucocorticoid receptor by the reconstituted hsp90-based chaperone machinery. J. Biol. Chem. 272: 13047-13054.
14. Dittmar, K.D., M. Banach, M.D. Galigniana, and W.B. Pratt. 1998. The role of Dna-J-like proteins in glucocorticoid receptor-hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex. J. Biol. Chem. 273:7358-7366.
15. Fejes-Tóth, G., D. Pearce, and A. Náray-Fejes-Tóth. 1998. Subcellular localization of mineralocorticoid receptor in living cells: effects of receptor agonists and antagonists. Proc. Natl. Acad. Sci. USA. 95:2973-2978.
16. Froesch, B.A., S. Takayama, and J.C. Reed. 1998. BAG-1L protein enhances androgen receptor function. J. Biol. Chem. 273:11660-11666.
17. Frydman, J., and J. Höhfeld. 1997. Chaperones get in touch: the hip-hop connection. Trends Biochem. Sci. 22:87-92.
18. Gast, A., F. Neuschmid-Kaspar, H. Klocker, and A.C.B. Cato. 1995. A single amino acid exchange abolishes dimerization of androgen receptor and causes Reifenstein syndrome. Mol. Cell. Endocrinol. 111:93-98.
19. Gebauer, M., M. Zeiner, and U. Gehring. 1997. Proteins interacting with the molecular chaperone hsp70/hsc70: physical associations and effects on refolding activity. FEBS Lett. 417:109-113.
20. Gebauer, M., M. Zeiner, and U. Gehring. 1998. Interference between proteins Hap46 and Hop/p60, which bind to different domains of the molecular chaperone hsp70/hsc70. Mol. Cell. Biol. 18:6238-6244.
21. Giguère, V., S.M. Hollenberg, M.G. Rosenfeld, and R.M. Evans. 1986. Functional domains of the human glucocorticoid receptor. Cell. 46:645-652.
22. Hartl, F.U. 1996. Molecular chaperones in cellular protein folding. Nature. 381: 571-580.
23. Heck, S., M. Kullmann, A. Gast, H. Ponta, H.J. Rahmsdorf, P. Herrlich, and A.C.B. Cato. 1994. A distinct modulating domain of glucocorticoid receptor in the repression of activity of the transcription factor AP-1. EMBO (Eur. Mol. Biol. Organ.) J. 13:4087-4095.
24. Heck, S., K. Bender, M. Kullmann, M. Göttlicher, P. Herrlich, and A.C.B. Cato. 1997. IκBα-independent downregulation of NF-κB activity by glucocorticoid receptor. EMBO (Eur. Mol. Biol. Organ.) J. 16:4698-4707.
25. Herscovics, A., J. Schneikert, A. Athanassiadis, and K. Moremen. 1994. Isolation of a mouse Golgi mannosidase cDNA, member of a gene family conserved from yeast to mammals. J. Biol. Chem. 269:9864-9871.
26. Höhfeld, J., and S. Jentsch. 1997. GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO (Eur. Mol. Biol. Organ.) J. 16: 6209-6216.
27. Höhfeld, J., Y. Minami, and F.-U. Hartl. 1995. Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle. Cell. 83:589-598.
28. Hollenberg, S.M., V. Giguère, P. Segui, and R.M. Evans. 1987. Colocalization of DNA-binding and transactivation functions in the human glucocorticoid receptor. Cell. 49:39-46.
29. Hutchison, K.A., K.D. Dittmar, M.J. Czar, and W.B. Pratt. 1994. Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90.1. Biol. Chem. 269:5043-5049.
30. Johnson, B.D., R.J. Schumacher, E.D. Ross, and D.O. Toft. 1998. Hop modulates hsp70/hsp90 interactions in protein folding. J. Biol. Chem. 273:3679-3686.
31. Kaspar, F., H. Klocker, A. Denninger, and A.C.B. Cato. 1993. A mutant androgen receptor from patients with Reifenstein syndrome: identification of the function of a conserved alanine residue in the D box of steroid receptors. Mol Cell. Biol. 13:7850-7858.
32. Klocker, H., F. Kaspar, J. Eberle, S. Überreiter, C. Radmayr, and G. Bartsch. 1992. Point mutation in the DNA binding domain of the androgen receptor in two families with Reifenstein syndrome. Am. J. Hum. Genet. 50:1318-1327.
33. Kullmann, M., J. Schneikert, J. Moll, S. Heck, M. Zeiner, U. Gehring, and A.C.B. Cato. 1998. RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. J. Biol. Chem. 273:14620-14625.
34. Liu, R., S. Takayama, Y. Zheng, B. Froesch, G.-Q Chen, X. Xhang, J.C. Reed, and X.-K. Zhang. 1998. Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. J. Biol. Chem. 273:16985-16992.
35. McEwan, J.I., A.P.H. Wright, and J.-Å. Gustafsson. 1997. Mechanism of gene expression by the glucocorticoid receptor: role of protein-protein interactions. BioEssays. 19:153-160.
36. Packham, G., M. Brimmell, and J.L. Cleveland. 1997. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. Biochem. J. 328:807-813.
37. Pratt, W.B., and K.D. Dittmar. 1998. Studies with purified chaperones advance the understanding of the mechanism of glucocorticoid receptor-hsp90 heterocomplex assembly. Trends Endocrinol. Metab. 5:244-252.
38. Rassow, J., O. von Ahsen, U. Borner, and N. Pfanner. 1997. Molecular chaperones: towards a characterization of the heat-shock protein 70 family. Trends Cell Biol. 7:129-133.
39. Schneikert, J., H. Peterziel, P.-A. Defossez, H. Klocker, Y. de Launoit, and A.C.B. Cato. 1996. Androgen receptor-Ets protein interaction is a novel mechanism for steroid hormone-mediated down-regulation of matrix metalloproteinase expression. J. Biol. Chem. 271:23907-23913.
40. Srinivasan, G., N.T. Patel, E.B. Thompson. 1994. Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor: glucocorticoid response element complex. Mol. Endocrinol. 8:189-196.
41. Stuart, J.K., D.G. Myszka, L. Joss, R.S. Mitchell, S.M. McDonald, Z. Xie, S. Takayama, J.C. Reed, and K.R. Ely. 1998. Characterization of interactions between the anti-apoptotic protein BAG-1 and hsp70 molecular chaperones. J. Biol. Chem. 273:22506-22514.
42. Takayama, S., T. Sato, S. Krajewski, K. Kochel, S. Irie, J.A. Millan, and J.C. Reed. 1995. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 80:279-284.
43. Takayama, S., D.N. Bimston, S.-i. Matsuzawa, B.C. Freeman, C. Aime-Sempe, Z. Xie, R.I. Morimoto, and J.C. Reed. 1997. BAG-1 modulates the chaperone activity of hsp70/hsc70. EMBO (Eur. Mol. Biol. Organ.) J. 16:4887-4896.
44. Takayama, S., S. Krajewski, M. Krajewska, S. Kitada, J.M. Zapata, K. Kochel, D. Knee, D. Scudiero, G. Tudor, G.J. Miller, et al. 1998. Expression and localization of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissue and tumor cell lines. Cancer Res. 58:3116-3131.
45. Wang, H.-G., S. Takayama, U.R. Rapp, and J.C. Reed. 1996. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl. Acad. Sci. USA. 93:7063-7068.
46. Wells, R.J., K. Mascaro, P.C. Young, A.J. Provisor, R.E. Cleary, and R.L. Baehner. 1981. Normal glucocorticoid receptor numbers in a child with glucocorticoid-resistant relapsed acute lymphocytic leukemia. Am. J. Pediatr. Hematol. Oncol. 3:3-7.
47. Yang, X., G. Chernenko, Y. Hao, Z. Ding, M.M. Pater, A. Pater, and S.-C. Tang. 1998. Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells. Oncogens. 17:981-989.
48. Zeiner, M., and U. Gehring. 1995. A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc. Natl. Acad. Sci. USA. 92:11465-11469.
49. Zeiner, M., M. Gebauer, and U. Gehring. 1997. Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO (Eur. Mol. Biol. Organ.) J. 16:5483-5490.