Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells

Journal of Cellular Biochemistry

Volumn 66, Issue 3, 1997, Pages 309-321

  Yang, Xiaolong ^a   Nakao, Yoshifumi ^a,b   Pater, Mary M ^d   Tang, Shou Ching ^a,c   Pater, Alan ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b SAGA UNIVERSITY   (Japan)

^c Dr H Bliss Murphy Cancer Centre   (Canada)

^d Division of Basic Medical Sciences ^*

Author keywords

Human papillomavirus type 16; Immortalization; mRNA; Oncogenes; Oncogenesis; Proteins; Senescence; Smoking cofactor; Tumor suppressors; Tumorigenesis

Indexed keywords

CIGARETTE SMOKE;

ARTICLE; CANCER RISK; CARCINOGENESIS; CELL TRANSFORMATION; CIGARETTE SMOKING; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA; WART VIRUS;

ACTINS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; CERVIX UTERI; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; ONCOGENES; PAPILLOMAVIRIDAE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SMOKE; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPES;

EID: 0030846551     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19970901)66:3<309::AID-JCB4>3.0.CO;2-T     Document Type: Article

References (59)

1. Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. Int J Cancer 61:115-120.
2. Brenner AJ, Aldaz CM (1995): Chromosome 9p allelic loss and p/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells. Cancer Res 55:2892-2895.
3. Butz K, Shahabeddin L, Geisen C, Spitkovsky D, Ulmann A, Hoppe-Seyler F (1995): Functional p53 protein in human papillomavirus-positive cancer cells. Oncogene 10:927-936.
4. Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A, Mao L, Herath J, Jenkins R, Westra W, Rutter JL, Buckler A, Gabrielson E, Tockman M, Cho KR, Hedrick L, Bova GS, Isaacs W, Koch W, Schwab D, Sidransky D (1995): Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nature Genet 11:210-212.
5. Chen CY, Oliner JD, Zhan Q, Fornace AJ, Vogelstein B, Kastan MB (1994): Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc Natl Acad Sci USA 91:2684-2688.
6. Crook T, Greenfield I, Howard J, Stanley M (1990): Alterations in growth properties of human papilloma virus type 16 immortalised human cervical keratinocyte cell line correlate with amplification and overexpression of c-myc oncogene. Oncogene 5:619-622.
7. Demeter LM, Stoler MH, Broker TR, Chow LT (1994): Induction of proliferating cell nuclear antigen in differentiated keratinocytes of human papillomavirus-infected lesions. Hum Pathol 25:343-348.
8. DiPaolo JA, Woodworth CD, Popescu NC, Notario V, Doniger J (1989): Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral Harvey ras. Oncogene 4:395-399.
9. Durst M, Croce CM, Gissmann L, Schwarz E, Huebner K (1987a): Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc Natl Acad Sci USA 84:1070-1074.
10. Durst M, Dzarlieva-Petrusevska RT, Boukamp P, Fusenig NE, Gissmann L (1987b): Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene 1:251-256.
11. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993): Waf1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
12. Garrett LR, Perez-Reyes, Smith PP, McDougall JK (1993): Interaction of HPV-18 and nitrosomethylurea in the induction of squamous cell carcinoma. Carcinogenesis 14:329-332.
13. Hall PA, Levison DA, Woods AL, Yu CC-W, Kellock DB, Watkins JA, Barnes DM, Gillett CE, Camplejohn R, Dover R, Waseem NH, Lane DP (1990): Proliferating cell nuclear antigen immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162:285-294.
14. 1 cyclin-dependent kinases. Cell 75:805-816.
15. Herrington CS (1995): Human papillomaviruses and cervical neoplasia. II. Interaction of HPV with other factors. J Clin Pathol 48:1-6.
16. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS, Johnson BE, Skolnick MH (1994): A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436-440.
17. Karakitsos P, Kyroudes A, Apostolaki C, Paizi P, Voulgaris Z, Alekou G, Kyrkou K (1994): The evaluation of PCNA/cyclin expression in cervical intraepithelial lesions. Gynecol Oncol 55:101-107.
18. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ (1992): A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia. Cell 71:587-597.
19. Khandjian EW, Salomon C, Leonard N, Tremblay S, Turler H (1992): Fibronectin gene expression in proliferating, quiescent, and SV40-infected mouse kidney cells. Exp Cell Res 202:464-470.
20. Klingelhutz AJ, Smith PP, Garrett LR, McDougall JK (1993): Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea. Oncogene 8:95-99.
21. Kumazaki T, Robetorye RS, Robetorye SC, Smith JR (1991): Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area. Exp Cell Res 195:13-19.
22. Lam EW-F, Morris DH, Davies R, Crook T, Watsom RJ, Vousden KH (1994): HPV16 E7 oncoprotein deregulates B-myb expression: Correlation with targeting of p107/E2F complexes. EMBO J 13:871-878.
23. Li S-L, Kim M-S, Cherrick HM, Doniger J, Park N-H (1992): Sequential combined tumorigenic effect of HPV-16 and chemical carcinogens. Carcinogenesis 13:1981-1987.
24. 1 arrest. Proc Natl Acad Sci USA 91:10079-10083.
25. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J (1995): Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375:503-506.
26. ink4 requires functional retinoblastoma protein. Proc Natl Acad Sci USA 92:6289-6293.
27. Mullokandov MR, Kholodilov NG, Atkin NB, Burk RD, Johnson AB, Klinger HP (1996): Genomic alterations in cervical carcinoma: Losses of chromosome heterozygosity and human papilloma virus status. Cancer Res 56:197-205.
28. Nakao Y, Yang X, Yokoyama M, Pater MM, Pater A (1996): Malignant transformation of human ectocervical cells immortalized by Hpv18: In vitro model of carcinogenesis by cigarette smoke. Carcinogenesis 17:577-583.
29. Nakao Y, Yang X, Yokoyama M, Ferenczy A, Tang S-C, Pater MM, Pater A (1997): Induction of p16 during immortalization by HPV16 and 18 and not during malignant transformation. Br J Cancer 75:1410-1416.
30. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA (1994): Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368:753-756.
31. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR (1994): Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98.
32. Ocadiz R, Sauceda R, Cruz M, Graef AM, Gariglio P (1987): High correlation between molecular alteration of the c-myc oncogene and carcinoma of the uterine cervix. Cancer Res 47:4173-4177.
33. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992): Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83.
34. Park N-H, Gujuluva GN, Baek J-H, Cherrick HM, Shin K-H, Min B-M (1995): Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: An in vitro multistep carcinogenesis model. Oncogene 10:2145-2153.
35. Parkin DM, Pisani P, Ferlay J (1993): Estimates of the worldwide frequency of eighteen major cancers in 1985. Int J Cancer 54:594-606.
36. 1 checkpoint is retained in tumorigenic rat embryo fibroblast clones transformed by the human papillomavirus type 16 E7 gene and EJ-ras. Mol Cell Biol 15:1446-1454.
37. Pei X, Meck JM, Greenhalgh D, Schlegel R (1993): Cotransfection of HPV-18 and v-fos NA induces tumorigenicity of primary human keratinocytes. Virology 196:855-860.
38. Pereira-Smith OM, Smith JR (1988): Genetic analysis of indefinite division in human cells: Identification of four complementation groups. Proc Natl Acad Sci USA 85:6042-6046.
39. Sagae S, Kudo R, Kuzumaki N, Hisada T, Mugikura Y, Nihei T, Takeda T, Hashimoto M (1989): ras oncogene expression and progression in intraepithelial neoplasia of the uterine cervix. Cancer 66:295-301.
40. Sambrook J, Fritsch EF, Maniatis T (1989): "Molecular Cloning: A Laboratory Manual." Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
41. Sarma D, Yang X, Jin G, Shindoh M, Pater MM, Pater A (1996): Resistance to retinoic acid and altered cytokeratin expression of human papillomavirus type 16-immortalized endocervical cells after tumorigenesis. Int J Cancer 65:345-350.
42. Saxon PJ, Srivatsan ES, Stanbridge E (1986): Introduction of human chromosome 11 via microcell transfer controls tumorigenic expression of HeLa cells. EMBO J 5:3461-3466.
43. Scheffner M, Munger K, Byrne JC, Howley PM (1991): The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc Natl Acad Sci USA 88:5523-5527.
44. Scheffner M, Romanczuk H, Munger K, Hribregtse JM, Mietz JA, Howley PM (1994): Functions of human papillomavirus proteins. Curr Top Microbiol Immunol 186:83-99.
45. Shin K-H, Min B-M, Cerrick HM, Park N-H (1994): Combined effects of human papillomavirus-18 and N-methyl-N′-nitro-N-nitrosoguanidine on the transformation of normal human oral keratinocytes. Mol Carcinog 9:76-86.
46. Shindoh M, Sun Q, Pater A, Pater MM (1995): Prevention of carcinoma in situ of human papillomavirus type 16-immortalized human endocervical cells by retinoic acid in organotypic raft culture. Obstet Gynecol 85:721-728.
47. Subler MA, Martin DW, Deb S (1992): Inhibition of viral and cellular promoters by human wild-type p53. J Virol 66:4757-4762.
48. Sun Q, Tsutsumi K, Kelleher M, Pater A, Pater MM (1992): Squamous metaplasia of normal and carcinoma in situ of HPV 16-immortalized human endocervical cells. Cancer Res 52:4254-4260.
49. Suzuki Y, Orita M, Shiraishi M, Hayashi K, Sekiya T (1990): Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene 5:1037-1043.
50. Tsutsumi K, Belaguli N, Sun Q, Michalak TI, Gulliver WP, Pater A, Pater MM (1992): Human papillomavirus 16 DNA immortalizes two types of normal human epithelial cells of the uterine cervix. Am J Pathol 140:255-261.
51. Werness BA, Levine AJ, Howley PM (1990): Association of human papillomavirus type 16 and 18 E6 proteins with p53. Science 248:76-79.
52. Woodworth CD, Waggoner S, Barnes W, Stoler MH, DiPaolo JA (1990): Human cervical and foreskin epithelial cells immortalized by human papillomavirus DNAs exhibit dysplastic differentiation in vivo. Cancer Res 50:3709-3715.
53. Yang X, Jin G, Nakao Y, Rahimtula M, Pater MM, Pater A (1996a): Malignant transformation of HPV16-immortalized human endocervical cells by cigarette smoke condensate and characterization of multistage carcinogenesis. Int J Cancer 65:338-344.
54. Yang X, Nakao Y, Pater MM, Pater A (1996b): Identification of two novel cellular genes associated with multistage carcinogenesis of human endocervical cells by mRNA differential display. Carcinogenesis 17:563-567.
55. Zambetti GP, Levine AJ (1993): A comparison of the biological activities of wild-type and mutant p53. FASEB J 7:855-865.
56. Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MYWT (1994): DNA polymerase δ is involved in the cellular response to UV damage in human cells. J Biol Chem 269:13748-13751.
57. zur Hausen H (1982): Human genital cancer: Synergism between two virus infections or synergism between a virus infection and preinitiating events? Lancet ii:1370-1372.
58. zur Hausen H (1991): Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.
59. zur Hausen H, Villiers E-M (1994): Human papillomaviruses. Annu Rev Microbiol 48:427-447.