Primary non-random X inactivation associated with disruption of Xist promoter regulation

Human Molecular Genetics

Volumn 10, Issue 6, 2001, Pages 581-589

  Newall, Alistair E T ^a   Duthie, Sarah ^a   Formstone, Emma ^a   Nesterova, Tatyana ^a   Alexiou, Maria ^b   Johnston, Colette ^a   Caparros, Marie Laure ^a   Brockdorff, Neil ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MUTANT; CONTROLLED STUDY; DNA STRAND; EMBRYO; FEMALE; GENE ACTIVATION; GENE CASSETTE; GENE DISRUPTION; GENE LOCUS; GENE TARGETING; GENETIC REGULATION; GENETIC TRANSCRIPTION; HETEROZYGOSITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; TRANSCRIPTION INITIATION; X CHROMOSOME INACTIVATION;

ANIMALIA;

EID: 0035869112     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.6.581     Document Type: Article

References (42)

1. Gene action in the X chromosome of the mouse (Mus musculus L.)
2. Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse
3. Controlling elements in the mouse X-chromosome. I. Interaction with the X-linked genes
4. Primary non-random X-inactivation caused by controlling elements in the mouse demonstrated at the cellular level
5. X-chromosome activity in female mouse embryos heterozygous for Pgk-1 and Searle's translocation, T(X; 16) 16H
6. The use of X-autosome translocations in locating the X-chromosome inactivation centre
7. The search for the mouse X-chromosome inactivation centre
8. Non-random X-chromosome inactivation in mouse X-autosome translocation embryos-location of the inactivation centre
9. Characterization of a murine gene expressed from the inactive X chromosome
10. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome
11. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
12. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
13. The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
14. A 450 kb transgene displays properties of the mammalian X-inactivation center
15. Requirement for Xist in X chromosome inactivation
16. XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear/chromosome structure
17. Developmentally regulated Xist promoter switch mediates initiation of X inactivation
18. X chromosome inactivation is mediated by Xist RNA stabilization
19. Stabilization of Xist RNA mediates initiation of X chromosome
20. Tsix, a gene antisense to Xist at the X-inactivation centre
21. Functional analysis of the DXPas34 locus, a 3′ regulator of Xist expression
22. Further examination of the Xist promoter-switch hypothesis in X inactivation: Evidence agaisnt the existence and function of a P(O) promoter
23. Targeted mutagenesis of Tsix leads to nonrandom X inactivation
24. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
25. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix
26. Xist has properties of the X-chromosome inactivation centre
27. Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation
28. Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain
29. Role of the Xist gene in X chromosome choosing
30. Mapping the murine Xce locus with (CA)n repeats
31. Regulatory elements in the minimal promoter region of the mouse Xist gene
32. Xist-deficient mice are defective in dosage compensation but not spermatogenesis
33. Timing of X-chromosome inactivation in postimplantation mouse embryos
34. Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus
35. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus
36. A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation
37. Human XIST yeast artificial chromosome transgenes show partial X inactivation center function in mouse embryonic stem cells
38. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation
39. The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression
40. A sensitive, quantitative assay for measurement of allele-specific transcripts differing by a single nucleotide
41. Xist RNA exhibits a banded localization on the inactive X chromosome and is excluded from autosomal material in cis
42. Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome