From hit to lead. Analyzing structure-profile relationships

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3391-3401

  Poulain, R ^a   Horvath, D ^a,b   Bonnet, B ^a,d   Eckhoff, C ^a   Chapelain, B ^c   Bodinier, M C ^a   Deprez B ^a,d  

^a CEREP Celle l'Evescault BP1   (France)

^b CEREP   (France)

^c Cerep Inc   (United States)

^d Devgen NV   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 [BIS(4 FLUOROPHENYL)METHOXY]ETHYL] 4 (3 PHENYLALLYL)PIPERAZINE DIMESILATE; 1 PHENYL 1,3,8 TRIAZASPIRO[4,5]DECAN 4 ONE; 1 PIPERIDIN 4 YL 1,3 DIYDROBENZIMIDAZOL 2 ONE; BRAIN RECEPTOR; CARRIER PROTEIN; FLUNARIZINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; PIMOZIDE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; VANOXERINE;

ARTICLE; DOSE RESPONSE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; IC 50; MOLECULAR MODEL; PHARMACOPHORE; RECEPTOR AFFINITY; STATISTICAL ANALYSIS; STRUCTURE ACTIVITY RELATION; TECHNIQUE;

BRAIN; CARRIER PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; DATA INTERPRETATION, STATISTICAL; ION CHANNELS; LIGANDS; MODELS, MOLECULAR; PIPERAZINES; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035846172     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010878g     Document Type: Article

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