Opioid antagonist activity of naltrexone-derived bivalent ligands: Importance of a properly oriented molecular scaffold to guide "address" recognition at κ opioid receptors

Journal of Medicinal Chemistry

Volumn 39, Issue 9, 1996, Pages 1816-1822

  Bolognesi, MariaLaura ^a   Ojala, William H ^b   Gleason, William B ^b   Griffin, Jane F ^c   Farouz Grant, Francine ^a   Larson, Dennis L ^a   Takemori, Akira E ^b   Portoghese, Philip S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; ETHYLKETAZOCINE; KAPPA OPIATE RECEPTOR; NALTREXONE DERIVATIVE; NORBINALTORPHIMINE; OPIATE AGONIST; OPIATE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; GUINEA PIG; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BINDING SITES; GUINEA PIGS; ILEUM; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; NALTREXONE; RECEPTORS, OPIOID, KAPPA; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 0029875344     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950807f     Document Type: Article

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