A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1514-1520

  Roufos, Ioannis ^a   Hays, Sheryl ^a   Schwarz, Roy D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITINE; BATRACHOTOXIN; CIGUATOXIN; DIPHENYLACETIC ACID; LOCAL ANESTHETIC AGENT; N [3 (2,6 DIMETHYL 1 PIPERIDINYL)PROPYL] ALPHA PHENYLBENZENEACETAMIDE; N [3 [2,6 DIMETHYL 1 PIPERIDINYL]PROPYL] ALPHA PHENYLBENZENEACETAMIDE; NEUROTOXIN; PHENYL GROUP; SCORPION VENOM; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VERATRIDINE;

ANTIARRHYTHMIC ACTIVITY; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CEREBROVASCULAR ACCIDENT; CHO CELL; HEART ARRHYTHMIA; HEART EXCITATION; HEART MUSCLE; LIPOPHILICITY; LOCAL ANESTHESIA; MOLECULAR CLONING; PROTEIN CONFORMATION; RECEPTOR BINDING; SODIUM TRANSPORT; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; BENZENEACETAMIDES; CHO CELLS; CRICETINAE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PIPERIDINES; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; VERATRIDINE;

EID: 0030007482     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950467y     Document Type: Article

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