3. Endothelin antagonists: Discovery of EMD 122946, a highly potent and orally active ET(A) selective antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 13, 1998, Pages 1771-1776

  Mederski, Werner W K R ^a   Dorsch, Dieter ^a   Osswald, Mathias ^a   Anzali, Soheila ^a   Christadler, Maria ^a   Schmitges, Claus Jochen ^a   Schelling, Pierre ^a   Wilm, Claudia ^a   Fluck, Markus ^a  

^a NONE

Author keywords

Antihypertensive activity; Benzothiadiazole; Butenolide; Endothelin; ET(A) antagonist

Indexed keywords

EMD 122801; EMD 122946; EMD 94246; ENDOTHELIN A RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; HYPERTENSION; NONHUMAN; PRESSOR RESPONSE; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; SWINE;

ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; ENDOTHELIN-1; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; SWINE; THIAZOLES;

EID: 0032493194     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00301-1     Document Type: Article

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