From hit to lead. Combining two complementary methods for focused library design. Application to μ opiate ligands

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3378-3390

  Poulain, R ^a   Horvath, D ^a,b   Bonnet, B ^d   Eckhoff, C ^a   Chapelain, B ^c   Bodinier, M C ^a   Deprez B ^a,d  

^a CEREP Celle l'Evescault BP1   (France)

^b CEREP   (France)

^c Cerep Inc   (United States)

^d Devgen NV   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 [8 [(6 CHLOROBENZO[1,3]DIOXOL 5 YL)METHYL] 4 OXO 1 PHENYL 1,3,8 TRIAZASPIRO[4,5]DEC 3 YL] N METHYLACETAMIDE TRIFLUOROACETATE; 4 (2 OXOBENZIMIDAZOL 1 YL)PIPERIDINE 1 CARBOXYLIC ACID (6 NITROBENZO[1,3]DIOXOL 5 YL)METHYL ESTER; ACETAMIDE DERIVATIVE; MU OPIATE RECEPTOR; N METHYL 3 (4 OXO 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECYL)ACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; COMPUTER ANALYSIS; DRUG DESIGN; DRUG SYNTHESIS; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR MODEL; PHARMACOPHORE; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CEREBRAL CORTEX; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; IMIDAZOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, MU; SOLUBILITY; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035846123     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010877o     Document Type: Article

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