Modular enzymes

Nature

Volumn 409, Issue 6817, 2001, Pages 247-252

  Khosla, C ^a   Harbury, P B ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; MULTIENZYME COMPLEX;

CATALYSIS; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SYNTHESIS; METABOLISM; MOLECULAR RECOGNITION; PRIORITY JOURNAL; REVIEW;

CATALYSIS; ENZYMES; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; SUBSTRATE SPECIFICITY;

EID: 0035843184     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35051723     Document Type: Review

References (56)

1. General nature of the genetic code for proteins
2. Modular binding proteins in signal transduction proteins
3. From Src homology domains to other signaling modules: Proposal of the protein recognition code
4. Modular structure of transcription factors: Implications for gene regulation
5. Imposing specificity by localization: Mechanism and evolvability
6. Location of domains in globular proteins
7. Protein superfamilies and domain superfolds
8. Gene families: The taxonomy of protein paralogs and chimeras
9. Protein evolution viewed th rough Escherichia coli protein sequences: Introducing the notion ora structural segment of homology, the module
10. Protein alchemy: Changing β-sheet into α-helix
11. Functional domains in Fok-I restriction endonuclease
12. Hybrid restriction enzymes - Zinc finger fusions to Fok I cleavage domain
13. Splase - A new class 1 zinc-finger restriction endonuclease with specificity for Sp1 binding sites
14. Novel site-specific DNA endonucleases
15. Homologous xylanases from Clostridium thermocellum: Evidence for bifunctional activity; synergism between xylanase catalytic modules and the presence of xylan-binding domains in enzyme complexes
16. Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity
17. Detecting protein function and protein-protein interactions from genome sequences
18. On the attribution and additivity of binding energies
19. Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme
20. Engineering Src family protein kinases with unnatural nucleotide specificity
21. Converting trypsin to chymotrypsin-ground-state binding does not determine substrate specificity
22. Rapid evolution ora protein in vitro by DNA shuffling
23. Bacterial biocatalysts: Molecular biology, three dimensional structures, and biotechnological applications of lipases
24. Enzymes and protecting group chemistry
25. Selective deprotection of phthalyl protected amines
26. A structure-activity study with aryl acylamidases
27. Preparative biotransformations: The employment of enzymes and whole-cells in synthetic organic chemistry
28. Preparative biotransformations
29. Preparative biotransformations
30. Penicillin acylase has a single amino-acid catalytic centre
31. Ligand-induced conformational change in penicillin acylase
32. Structural basis of the chiral selectivity of Pseudomonas cepacia lipase
33. Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine
34. The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis
35. The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation
36. Biosynthesis of desosamine: Construction of a new macrolide carrying a genetically designed sugar moiety
37. A two-plasmid system for the glycosylation of polyketide antibiotics: Bioconversion of epsilon-rhodomycinone to rhodomycin D
38. Conserved domains of glycosyltransferases
39. Harnessing the biosynthetic code. Combinations, permutations, mutations
40. Tolerance and specificity of polyketide synthases
41. Design and application of multimodular peptide synthetases
42. Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis
43. Analysis of the molecular recognition features of individual modules derived from the erythromycin polyketide synthase
44. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural"natural products
45. A novel, definitive test for substrate channeling illustrated with the aspartate aminotransferase/malate dehydrogenase system
46. Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium
47. Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site
48. Structure of carbamoyl phosphate synthetase: A journey of 96 Å from substrate to product
49. Swinging arms in multifunctional enzymes and the specificity of postranslational modification
50. Preferential heterodimer formation by isolated leucine zippers from Fos and Jun
51. Molscript - A program to produce both detailed and schematic plots of protein structures
52. Gain of function mutagenesis of a modular polyketide synthase II. Engineered biosynthesis of an eight-membered ring tetraketide lactone
53. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
54. Modular organization of genes required for complex polyketide biosynthesis