Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex

EMBO Journal

Volumn 18, Issue 7, 1999, Pages 1878-1890

  Le Cam, Laurent ^a   Polanowska, Jolanta ^a   Fabbrizio, Eric ^a   Olivier, Magali ^a   Philips, Alexandre ^a   Eaton, Eleonor Ng ^b   Classon, Marie ^c   Geng, Yan ^d   Sardet, Claude ^a  

^a CNRS   (France)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cell cycle; Cyclin E; E2F; Pocket protein; Transcriptional repression

Indexed keywords

CYCLIN E; DNA BINDING PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA SEQUENCE; GENE INDUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; REPRESSOR GENE; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0033118927     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.7.1878     Document Type: Article

References (45)

1. Bennett, J.D., Farlie, P.G. and Watson, R.J. (1996) E2F binding is required but not sufficient for repression of B-myb transcription in quiescent fibroblasts. Oncogene, 13, 1073-1082.
2. Botz, J., Zerfass-Thome, K., Spitkovsky, D., Delius, H., Vogt, B., Eilers, M., Hatzigeorgiou, A. and Jansen-Durr, P. (1996) Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol., 16, 3401-3409.
3. Cobrinik, D. et al. (1996) Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev., 10, 1633-1644.
4. 1/S-regulatory genes. Mol. Cell. Biol., 15, 4215-4224.
5. 1 to S transition in Drosophila: cyclin E is a limiting downstream target of E2F. Genes Dev., 9, 1456-1468.
6. 1-S transition. Mol. Cell. Biol., 18, 141-151.
7. Dyson, N. (1998) The regulation of E2F by pR-family proteins. Genes Dev., 12, 2245-2262.
8. Geng, Y., Eaton, E., Picon, M., Roberts, J.M., Lundberg, A., Gifford, A., Sardet, C. and Weinberg, R.A. (1996) Regulation of the cyclin E transcription by E2F and Retinoblastoma protein. Oncogene, 12, 1173-1180.
9. Hateboer, G., Wobst, A., Otzen, B., Le Cam, L., Vigo, E., Sardet, C. and Helin, K. (1998) Cell cycle-dependent regulation of the human cdc6 gene by E2F. Mol. Cell. Biol., 18, 6679-6697.
10. Herrera, R.E., Sah, V.P. Williams, B.O., Makela, T.P., Weinberg, R.A. and Tyler, J. (1996) Altered cell cycle kinetics, gene expression and G, restriction point regulation in RB-deficient fibroblasts. Mol. Cell. Biol., 16, 2402-2407.
11. Hua, X.H., Yan, H. and Newport, J. (1997) A role for cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle. J. Cell Biol., 137, 183-192.
12. Huet, X., Rech, J., Plet, A., Vié, A. and Blanchard, J.M. (1996) Cyclin A expression is under negative transcriptional control during the cell cycle. Mol. Cell. Biol., 16, 3789-3798.
13. Hurford, R.K., Cobrinik, D., Lee, M.H. and Dyson, N. (1997) pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev., 11, 1447-1463.
14. Karlseder, J., Rotheneder, H. and Wintersberger, E. (1996) Interaction of sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol., 16, 1659-1666.
15. Keyomarsi, K. and Herliczek, T.W. (1997) The role of cyclin E in cell proliferation, development and cancer. Prog. Cell Cycle Res., 3, 171-191.
16. Krude, T., Jackman, M., Pines, J. and Laskey, R.A., (1997) Cyclin/cdk-dependent initiation of DNA replication in a human cell-tree system. Cell, 88, 109-119.
17. Lam, E.W. and Watson, R.J. (1993) An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J., 12, 2705-2713.
18. Le Cam, L., Polanowska, J., Fabbrizio, E., Fajas, L. and Sardet, C. (1999) In vivo genomic footprinting of highly GC-rich promoters: A modification to the DMS-LMPCR technique. Biotechniques, in press.
19. LeCouter, J.E., Kablar, B., Hardy, W.R., Ying, C., Megeney, L.A., May, L.L. and Rudnicki, M.A. (1998) Strain-dependent myeloid hyperplasia. growth deficiency and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol. Cell. Biol., 18, 7455-7465.
20. Liu, N., Lucibello, F.C., Zwicker, J., Engeland, K. and Muller, R. (1996) Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element. Nucleic Acids Res., 24, 2905-2910.
21. Liu, N., Lucibello, F.C., Korner, K., Wolfraim, L.A., Zwicker, J. and Muller, R. (1997) CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated represser elements in multiple promoters. Nucleic Acids Res., 25, 4915-4920.
22. Liu, N., Lucibello, F.C., Engeland, K. and Muller, R. (1998) A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F. Oncogene, 16, 2957-2963.
23. Lucibello, F.C., Truss, M., Zwicker, J., Ehlert, F., Beato, M. and Muller, R. (1995) Periodic cdc25C transcription is mediated by a novel cell cycle-regulated repressor element (CDE). EMBO J., 14, 132-142.
24. Moberg, K., Starz, M.A. and Lees, J.A. (1996) E2F-4 switches from p130 to p107 and pRB in response to cell cycle re-entry. Mol. Cell. Biol., 16, 1436-1449.
25. Mueller, P.R. and Wold, B. (1989) In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science, 246, 780-786.
26. Mulligan, G. and Jacks, T. (1998) The retinoblastoma gene family: cousins with overlapping interests. Trends Genet., 14, 223-229.
27. Mulligan, G.J., Wong, J. and Jacks, T. (1998) p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol. Cell. Biol. 18, 206-220.
28. Nevins, J.R. (1998) Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ., 9, 585-593.
29. Ohtani, K., DeGregori, J. and Nevins, J.R. (1995) Regulation of the cylin E gene by transcription factor E2F1. Proc. Natl Acad. Sci. USA, 92, 12146-12150.
30. Philips, A., Huet, X., Plet, A., Le Cam, L., Vie, A. and Blanchard, J.M. (1998) The retinoblastoma protein is essential for cyclin A repression in quiescent cells. Oncogene, 11, 1373-1381.
31. Sardet, C., Vidal, M., Cobinik, D., Geng, Y., Onufrik, C., Chen, A. and Weinberg, B. (1995) E2F4 and E2F5, two members of the E2F family are expressed in the early phases of the cell cycle. Proc. Natl Acad. Sci. USA, 92, 2403-2407.
32. Sardet, C., Le Cam, L., Fabbrizio, E. and Vidal, M. (1997) E2Fs and the retinoblastoma protein family. In Karin, M., Ghysdael, J. and Yaniv, M. (eds), Progress in Gene Expression, Oncogenes as Transcriptional Regulators. Vol. 2. Birkhauser Verlag, Basel, Switzerland, pp. 1-62.
33. Spitkovsky, D. et al. (1994) Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. J. Virol., 68, 2206-2214.
34. 1 cell state. Mol. Cell. Biol., 16, 6965-6976.
35. Todaro, G.J., Lazar, G.K. and Green, H. (1965). The initiation of cell division in a contact-inhibited mammalian cell line. J. Cell Physiol., 66, 325-333.
36. Tommasi, S. and Pfeifer, G.P. (1995) In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol. Cell. Biol., 15, 6901-6913.
37. Vairo, G., Livingston, D.M. and Ginsberg, D. (1995) Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev., 9, 869-881.
38. Wells, J., Held, P., Illenye, S. and Heintz, N.H. (1996) Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle. Mol. Cell. Biol., 16, 634-647.
39. Zerfass, K., Schulze, A., Spitkovsky, D., Friedman, V., Henglein, B. and Jansen-Durr, P. (1995) Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J. Virol., 69, 6389-6399.
40. Zerfass, K., Spitkovsky, D., Schulze, A., Joswig, S., Henglein, B. and Jansen-Durr, P. (1996) Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107. J. Virol., 70, 2637-2642.
41. Zhu, Z. and Thiele, D.J. (1996) A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter. Cell, 87, 459-470.
42. Zwicker, J. and Muller, R. (1997) Cell-cycle regulation of gene expression by transcriptional repression. Trends Genet., 1, 3-6.
43. Zwicker, J., Lucibello, F.C., Wolfram, L.A., Gross, C., Trus, M., Engeland, K. and Müller, R. (1995) Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J., 14, 4514-4522.
44. Zwicker, J., Liu, N.S., Engeland, K., Lucibello, F.C. and Muller, R. (1996) Cell cycle regulation of E2F site occupation in vivo. Science, 271, 1595-1597.
45. Zwicker, J., Lucibello, F.C., Jerome, V., Brusselbach, S. and Muller, R. (1997) CDF-1-mediated repression of cell cycle genes targets a specific subset of transactivators. Nucleic Acids Res., 25, 4926-4932.