Structure of the human retinoblastoma-related p107 gene and its intragenic deletion in a B-cell lymphoma cell line

Gene

Volumn 251, Issue 1, 2000, Pages 37-43

  Ichimura, Koichi ^a,b   Hanafusa, Hiroko ^b   Takimoto, Hidetaka ^a   Ohgama, Yoichiro ^a,b   Akagi, Tadaatsu ^a   Shimizu, Kenji ^b  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Alu family; Exon intron structure; Homologous recombination; RB family

Indexed keywords

ARTICLE; B LYMPHOCYTE; CARCINOGENESIS; CONTROLLED STUDY; EXON; GENE DELETION; GENE STRUCTURE; GENETIC RECOMBINATION; GENOME; HUMAN; HUMAN CELL; INTRON; LYMPHOMA CELL LINE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; DNA, NEOPLASM; EXONS; GENE DELETION; GENES; HUMANS; INTRONS; LYMPHOMA, B-CELL; NUCLEAR PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P107; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; TUMOR CELLS, CULTURED;

EID: 0034643917     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00193-1     Document Type: Article

References (34)

1. Asimakopoulus F.A., White N.J., Nacheva E., Green A.R. Molecular analysis of chromosome 20q deletions associated with myeloproliferative disorders and myelodysplastic syndromes. Blood. 84:1994;3086-3094.
2. Baldi A., Boccia V., Claudio P.P., De Luca A., Giordano A. Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc. Natl. Acad. Sci. USA. 93:1996;4629-4632.
3. Chow K.N., Starostik P., Dean D.C. The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif. Mol. Cell. Biol. 16:1996;7173-7181.
4. Claudio P.P., Howard C.M., Baldi A., De Luca A., Fu Y., Condorelli G., Sun Y., Colburn N., Calabretta B., Giordano A. p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res. 54:1994;5556-5560.
5. Cobrinik D., Whyte P., Peeper D.S., Jacks T., Weinberg R.A. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 7:1993;2392-2404.
6. DeCaprio J.A., Ludlow J.W., Figge J., Shew J.Y., Huang C.M., Lee W.H., Marsilio E., Paucha E., Livingston D.M. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell. 54:1988;275-283.
7. Dyson N., Buchkovich K., Whyte P., Harlow E. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell. 58:1989;249-255.
8. Ewen M.E., Ludlow J.W., Marsilio E., DeCaprio J.A., Millikan R.C., Cheng S.H., Paucha E., Livingston D.M. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell. 58:1989;257-267.
9. Ewen M.E., Xing Y.G., Lawrence J.B., Livingston D.M. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell. 66:1991;1155-1164.
10. Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M., Dryja T.P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 323:1986;643-646.
11. Goodrich D.W., Wang N.P., Qian Y.W., Lee E.Y., Lee W.H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell. 67:1991;293-302.
12. Helin K., Holm K., Niebuhr A., Eiberg H., Tommerup N., Hougaard S., Poulsen H.S., Spang-Thomsen M., Norgaard P. Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc. Natl. Acad. Sci. USA. 94:1997;6933-6938.
13. Hong F.D., Huang H.J., To H., Young L.J., Oro A., Bookstein R., Lee E.Y., Lee W.H. Structure of the human retinoblastoma gene. Proc. Natl. Acad. Sci. USA. 86:1989;5502-5506.
14. Hu X., Worton R.G. Partial gene duplication as a cause of human disease. Hum. Mutat. 1:1992;3-12.
15. Ichinose I., Nakano S., Ohshima K., Mitsugi K., Anzai K., Shida T., Niho Y. Establishment of Epstein-Barr virus-negative diffuse large cell lymphoma cell line with an 8,22 chromosomal translocation. Cancer Res. 51:1991;5392-5397.
16. LeCouter J.E., Kablar B., Hardy W.R., Ying C., Megeney L.A., May L.L., Rudnicki M.A. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol. Cell. Biol. 18:1998;7455-7465.
17. Lee E.Y., Chang C.Y., Hu N., Wang Y.C., Lai C.C., Herrup K., Lee W.H., Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature. 359:1992;288-294.
18. Lehrman M.A., Goldstein J.L., Russell D.W., Brown M.S. Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia. Cell. 48:1987;827-835.
19. Mayol X., Grana X., Baldi A., Sang N., Hu Q., Giordano A. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene. 8:1993;2561-2566.
20. Minowada J., Ohnuma T., Moore G.E. Rosette-forming human lymphoid cell lines. Establishment and evidence for origin of thymus-derived lymphocytes. J. Natl. Cancer Inst. 49:1972;891-895.
21. Moberg K., Starz M.A., Lee J.A. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16:1996;1436-1449.
22. Mulligan G., Jacks T. The retinoblastoma gene family: cousins with overlapping interests. Trends Genet. 14:1998;223-229.
23. Robanus-Maandag E., Dekker M., van der Valk M., Carrozza M.L., Jeanny J.C., Dannenberg J.H., Berns A., te Riele H. p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12:1998;1599-1609.
24. Rothberg P.G., Ponnuru S., Baker D., Bradley J.F., Freeman A.I., Cibis G.W., Harris D.J., Heruth D.P. A deletion polymorphism due to Alu-Alu recombination in intron 2 of the retinoblastoma gene: association with human gliomas. Mol. Carcin. 19:1997;69-73.
25. Sandberg A.A., Chen Z. Cancer cytogenetics and molecular genetics: detection and therapeutic strategy. In Vivo. 8:1994;807-818.
26. Schwarz J.K., Devoto S.H., Smith E.J., Chellappan S.P., Jakoi L., Nevins J.R. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J. 12:1993;1013-1020.
27. Starostik P., Chow K.N., Dean D.C. Transcriptional repression and growth suppression by the p107 pocket protein. Mol. Cell. Biol. 16:1996;3606-3614.
28. Takimoto H., Tsukuda K., Ichimura K., Hanafusa H., Nakamura A., Oda M., Harada M., Shimizu K. Genetic alterations in the retinoblastoma protein-related p107 gene in human hematologic malignancies. Biochem. Biophys. Res. Commun. 251:1998;264-268.
29. Toguchida J., McGee T.L., Paterson J.C., Eagle J.R., Tucker S., Yandell D.W., Dryja T.P. Complete genomic sequence of the human retinoblastoma susceptibility gene. Genomics. 17:1993;535-543.
30. Weinberg R.A. The retinoblastoma gene and cell growth control. Trends Biochem. Sci. 15:1990;199-202.
31. Whyte P., Williamson N.M., Harlow E. Cellular targets for transformation by the adenovirus E1A proteins. Cell. 56:1989;67-75.
32. Xiao Z.X., Ginsberg D., Ewen M., Livingston D.M. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. USA. 93:1996;4633-4637.
33. Zhu L., van den Heuvel S., Helin K., Fattaey A., Ewen M., Livingston D., Dyson N., Harlow E. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7:1993;1111-1125.
34. Zhu L., Zhu L., Xie E., Chang L.S. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol. Cell. Biol. 15:1995;3552-3562.