A designed cavity in the hydrophobic core of a four-α-helix bundle improves volatile anesthetic binding affinity

Biochemistry

Volumn 37, Issue 5, 1998, Pages 1421-1429

  Johansson, Jonas S ^a,b,c   Gibney, Brian R ^a   Rabanal, Francesc ^a   Reddy, Konda S ^a   Dutton, P Leslie ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYSTEINE; HALOTHANE; INHALATION ANESTHETIC AGENT; LEUCINE; SYNTHETIC PEPTIDE; TRYPTOPHAN;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; DIMERIZATION; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; HYDROPHOBICITY; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FOLDING; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANESTHETICS, INHALATION; BINDING SITES; CYSTEINE; DRUG DESIGN; ELECTRON SPIN RESONANCE SPECTROSCOPY; HALOTHANE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRYPTOPHAN; WATER;

EID: 0032477890     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9721290     Document Type: Article

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