Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module

Journal of Experimental Medicine

Volumn 194, Issue 3, 2001, Pages 255-264

  Engels, N ^a   Merchant, M ^a   Pappu, R ^a   Chan, A C ^a   Longnecker, R ^a   Wienands, J ^a  

^a BIELEFELD UNIVERSITY   (Germany)

Author keywords

Antigen receptor; B lymphocytes; Epstein Barr virus; Signal transduction; SLP 65

Indexed keywords

LATENT MEMBRANE PROTEIN 2A; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL SURVIVAL; EPSTEIN BARR VIRUS; LATENT PERIOD; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VIRUS INFECTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; DNA PRIMERS; ENZYME INHIBITORS; ENZYME PRECURSORS; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NUCLEAR PROTEINS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION; TYROSINE; VANADATES; VIRAL MATRIX PROTEINS;

EID: 0035817250     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.3.255     Document Type: Article

References (64)

1. Epstein-Barr viruses
2. Molecular biology of Epstein-Barr virus
3. Epstein-Barr virus and its replication
4. A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1
5. Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes
6. An integral membrane protein (LMP) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking
7. Integral membrane protein 2 of Epstein-Barr-Virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases
8. Regulation of Epstein-Barr virus latency by latent membrane protein 2
9. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
10. Antigen receptor signaling gives lymphocytes a long life
11. The maintenance and the activation signal of the B-cell antigen receptor
12. Genetic analysis of B cell antigen receptor signaling
13. Signal transduction from the B cell antigen-receptor
14. The B cell antigen receptor: Formation of signaling complexes and the function of adaptor proteins
15. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
16. BLNK: A central linker protein in B cell activation
17. BASH, a novel signaling molecule preferentially expressed in B cells of the Bursa of Fabricius
18. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells
19. Association of phospholipase C-γ 2 Src homology 2 domain with BLNK is critical for B cell antigen receptor signaling
20. Interaction of SLP adaptors with the SH2 domain of Tec family kinases
21. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK: Functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
22. BLNK: Connecting Syk and Btk to calcium signals
23. Aberrant B cell development and immune response in mice with a compromised BCR complex
24. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin β
25. X-linked agammaglobulinemia and other immunoglobulin deficiencies
26. Signal transduction elements of the B cell antigen receptor and their role in immunodeficiencies
27. Requirement for B cell linker protein (BLNK) in B cell development
28. Abnormal development and function of B-lymphocytes in mice lacking the signaling adaptor protein SLP-65
29. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
30. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
31. Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR
32. Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction
33. The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction
34. An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase
35. An Epstein-Barr virus transformation-associated membrane protein interacts with Src family tyrosine kinases
36. Molecular mimicry of the antigen receptor signalling motif by transmembrane proteins of the Epstein-Barr virus and the bovine leukaemia virus
37. 2 signalling motif found in the cytoplasmic segments of the bovine leukaemia virus envelope protein and Epstein-Barr virus latent membrane protein 2A can elicit early and late lymphocyte activation
38. Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals
39. Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EμLMP2A transgenic mice
40. The LMP2A ITAM is essential for providing B cells with developmental and survival signals in vivo
41. An EBV-genome-negative cell line established from an American Burkitt lymphoma; receptor characteristics. EBV infectibility and permanent conversion into EBV-positive sublines by in vitro infection
42. Tyrosine-phosphorylated forms of Ig-β CD22, TCR-ζ and HOSS are major ligands for tandem SH2 domains of Syk
43. Evidence for a preformed transducer complex organized by the B cell antigen receptor
44. In vitro characterization of major ligands for Src homology 2 domains derived from tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells
45. B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins
46. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb-2 and Shc adaptors, and the p85 subunit of phosphytidylinositol 3-kinase
47. Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, and Crk-L adaptors
48. Maintenance of human T cell anergy: Blocking of Il-2 gene transcription by activated Rap1
49. Role of the adapter protein CrkL in signal transduction of normal hematopoietic and BCR/Abl-transformed cells
50. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
51. The Cbl proto-oncoprotein: A negative regulator of immune receptor signal transduction
52. Cbl sets the threshold for autoimmunity
53. GTPases in antigen receptor signalling
54. An essential role for BLNK in human B cell development
55. Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk
56. Antigen receptor tail clue
57. Defective B cell development and function in Btk-deficient mice
58. Impaired expansion of mouse B cell progenitors lacking Btk
59. Physiological signals and oncogenesis mediated through Crk family adapter proteins
60. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases
61. The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases
62. Cbl suppresses B cell receptor-mediated phospholipase (PLC) γ activation by regulating B cell linker protein-PLC-γ2 binding
63. Activation of the Rap1 GTPase by the B cell antigen receptor
64. SH2 domains recognize specific phosphopeptide sequences