Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 1, 1998, Pages 7-12

  Van Dijk, Ko Willems ^a   Van Vlijmen, Bart J M ^b   Van Der Zee, Andre ^a   Van't Hof, Belinda ^b   Van Der Boom, Hans ^b   Kobayashi, Kunihisa ^c   Chan, Lawrence ^c   Havekes, Louis M ^b   Hofker, Marten H ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

ApoE variants; Atherosclerosis; Gene therapy; VLDL receptor

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; BETA GALACTOSIDASE; CHOLESTEROL; LIGAND; LIPOPROTEIN; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CHO CELL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAST PROTEIN LIQUID CHROMATOGRAPHY; GENE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HYPERCHOLESTEROLEMIA; LIPOPROTEIN METABOLISM; LIVER; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR BINDING; TRANSGENIC MOUSE;

EID: 0031974739     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.1.7     Document Type: Article

References (27)

1. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T. Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A. 1992;89:9252-9256.
2. Chen W, Goldstein JL, Brown MS. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated intemalization of the low density lipoprotein receptor. J Biol Chem. 1990;265:3116-3123.
3. Yamamoto T, Hoshino A, Takahashi S, Kawarabayasi Y, Iijima H, Sakai J. The role of the very low density lipoprotein receptor in the metabolism of plasma lipoproteins containing ApoE. Ann N Y Acad Sci. 1995;748:217-224.
4. Takahashi S, Suzuki J, Kohno M, Oida K, Tamai T, Miyabo S, Yamamoto T, Nakai T. Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase. J Biol Chem. 1995;270:15747-15754.
5. Wyne KL, Pathak K, Seabra MC, Hobbs HH. Expression of the VLDL receptor in endothelial cells. Arterioscler Thromb Vasc Biol. 1996;16:407-415.
6. Multhaupt HA, Gafvels ME, Kariko K, Jin H, Arenas Elliot C, Goldman BI, Strauss JF, Angelin B, Warhol MJ, McCrae KR. Expression of very low density lipoprotein receptor in the vascular wall: analysis of human tissues by in situ hybridization and immunohistochemistry. Am J Pathol. 1996;148:1985-1997.
7. Frykman PK, Brown MS, Yamamoto T, Goldstein JL, Herz J. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1995;92:8453-8457.
8. Suzuki J, Takahashi S, Oida K, Shimada A, Kohno M, Tamai T, Miyabo S, Yamamoto T, Nakai T. Lipid accumulation and foam cell formation in Chinese hamster ovary cells overexpressing very low density lipoprotein receptor. Biochem Biophys Res Commun. 1995;206:835-842.
9. Nakazato K, Ishibashi T, Shindo J, Shiomi M, Maruyama Y. Expression of very low density lipoprotein receptor mRNA in rabbit atherosclerotic lesions. Am J Pathol. 1996;149:1831-1838.
10. Rall SC Jr, Mahley RW. The role of apolipoprotein E genetic variants in lipoprotein disorders. J Intern Med. 1992;231:653-659.
11. Mahley RW, Rall SC Jr, Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease. 6th ed. New York, NY: McGraw-Hill, Inc; 1989:1195-1213.
12. de Knijff P, Van den Maagdenberg AMJM, Stalenhoef AFH, Gevers Leuven JA, Demacker PNM, Kuyt LP, Frants RR, Havekes LM. Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigenerational pedigree. J Clin Invest. 1991;88:643-655.
13. Chappell DA. High receptor binding activity of lipoproteins in atypical dysbetalipoproteinemia (type III hyperlipoproteinemia). J Clin Invest. 1989;84:1906-1915.
14. van Vlijmen BJ, van Dijk KW, van't Hof HB, van Gorp PJ, van der Zee A, van der Boom H, Breuer ML, Hofker MH, Havekes LM. In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 -> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice. J Biol Chem. 1996;271:30595-30602.
15. van Ree JH, van den Broek WJ, Dahlmans VE, Groot PH, Vidgeon Hart M, Frants RR, Wieringa B, Havekes LM, Hofker MH. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 1994;111:25-37.
16. Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest. 1993;92:883-893.
17. Willnow TE, Sheng Z, Ishibashi S, Herz J. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. 1994;264:1471-1474.
18. Kobayashi K, Oka K, Forte T, Ishida B, Teng B, Ishimura Oka K, Nakamuta M, Chan L. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J Biol Chem. 1996;271:6852-6860.
19. Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, Van Ormondt H, Hoeben RC, Van Der Eb AJ. Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther. 1996;7:215-222.
20. Kingsley DM, Krieger M. Receptor-mediated endocytosis of low density lipoprotein: somatic cell mutants define multiple genes required for expression of surface-receptor activity. Proc Natl Acad Sci U S A. 1984;81:5454-5458.
21. Billheimer DW, Eisenberg D, Levy RI. The metabolism of very low density lipoproteins, I: preliminary in vitro and in vivo observations. Biochim Biophys Acta. 1972;260:212-221.
22. Hendriks WL, van der Boom H, van Vark LC, Havekes LM. Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophages. Biochem J. 1996;314:563-568.
23. Otway S, Robinson DS. The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions. J Physiol (Lond). 1967;190:321-332.
24. Kozarsky KF, Jooss K, Donahee M, Strauss JF, Wilson JM. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat Genet. 1996;13:54-62.
25. Takahashi S, Oida K, Ookubo M, Suzuki J, Kohno M, Murase T, Yamamoto T, Nakai T. Very low density lipoprotein receptor binds apolipoprotein E2/2 as well as apolipoprotein E3/3. FEBS Lett. 1996;386:197-200.
26. Tsukamoto K, Smith P, Glick JM, Rader DJ. Liver-directed gene transfer and prolonged expression of three major human apoE isoforms in ApoE-deficient mice. J Clin Invest. 1997;100:107-114.
27. Yang Y, Ertl HC, Wilson JM. MHC class I-restricted cytotoxic T-lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity. 1994;1:433-442.