Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: Implications for splenectomized patients and vaccine design

Journal of Immunology

Volumn 164, Issue 12, 2000, Pages 6296-6302

  Ochsenbein, Adrian F ^a,b   Pinschewer, Daniel D ^a   Odermatt, Bernhard ^a   Ciurea, Adrian ^a   Hengartner, Hans ^a   Zinkernagel, Rolf M ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; IMMUNIZATION; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLENECTOMY; T LYMPHOCYTE;

EID: 0034660470     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.12.6296     Document Type: Article

References (49)

1. Fields, B. N. 1990. Fields Virology. Raven Press, New York.
2. Lamm, M. E. 1997. Interaction of antigens and antibodies at mucosal surfaces. Annu. Rev. Microbiol. 51:311.
3. Herzenberg, L. A., and A. B. Kantor. 1993. B-cell lineages exist in the mouse. Immunol. Today 14:79.
4. + B lymphocytes, polyreactive antibodies and the human B-cell repertoire. Immunol. Today 10:364.
5. Avrameas, S. 1991. Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton.' Immunol. Today 12:154.
6. Feldmann, M., and A. Easten. 1971. The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response. J. Exp. Med. 134:103.
7. Parker, D. C. 1993. T cell-dependent B cell activation. Annu. Rev. Immunol. 11:331.
8. Cambier, J. C., C. M. Pleiman, and M. R. Clark. 1994. Signal transduction by the B cell antigen receptor and its coreceptors. Annu. Rev. Immunol. 12:457.
9. Bachmann, M. F., H. Hengartner, and R. M. Zinkernagel. 1997. Neutralizing anti-viral B cell responses. Anna. Rev. Immunol. 15:235.
10. Bachmann, M. F., U. H. Rohrer, T. M. Kündig, K. Bürki, H. Hengartner, and R. M. Zinkernagel. 1993. The influence of antigen organization on B cell responsiveness. Science 262:1448.
11. Wagner, R. R. 1987. The Rhabdoviruses. Plenum Press, New York.
12. Bachmann, M. F., H. Hengartner, and R. M. Zinkernagel. 1995. T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction? Eur. J. Immunol. 25:3445.
13. Zinkernagel, R.M. 1996. Immunology taught by viruses. Science 271:173.
14. Noelle, R. J., M. Roy, D. M. Shepherd, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl. Acad. Sci. USA 89:6550.
15. Linsley, P. S., and J. A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
16. Crowly, M. T., K. Inaba, and R. M. Steinman. 1990. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172:383.
17. Guéry, J. C., F. Ria, and L. Adorini. 1996. Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvants. J. Exp. Med. 183:751.
18. Janeway, C. A. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54(Part 1):1.
19. Croft, M. 1994. Activation of naive, memory and effector T cells. Curr. Opin. Immunol. 6:431.
20. + T cells upon acute versus persistent viral infection. Immunity 9:449.
21. Roost, H.-P., S. Charan, and R. M. Zinkernagel. 1990. Analysis of the kinetics of antiviral memory T help in vivo: characterization of short-lived cross-reactive T help. Eur. J. Immunol. 20:2547.
22. Matsuura, Y., R. D. Possee, H. A. Overton, and D. H. Bishop. 1987. Baculovirus expression vectors: the requirements for high level expression of proteins, including glycoproteins. J. Gen. Virol. 68:1233.
23. Fehr, T., D. Skrastina, P. Pumpens, and R. M. Zinkernagel. 1998. T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles. Proc. Natl. Acad. Sci. USA 95:9477.
24. Leist, T. P., S. P. Cobbold, H. Waldmann, M. Aguet, and R. M. Zinkernagel. 1987. Functional analysis of T lymphocyte subsets in antiviral host defense J. Immunol. 138:2278.
25. Bachmann, M. F., T. M. Kündig, B. Odermatt, H. Hengartner, and R.M. Zinkernagel. 1994. Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells. J. Immunol. 153:3386.
26. Scott, D. W., and R. K. Gershon. 1970. Determination of total and mercaptoethanol-resistant antibody in the same serum sample. Clin. Exp. Immunol. 6:113.
27. Simons, K., A. Helenius, K. Leonard, M. Sarvas, and M. J. Gething. 1978. Formation of protein micelles from amphiphilic membrane proteins. Proc. Natl. Acad. Sci. USA 75:5306.
28. Johnson, D. C., M. J. Schlesinger, and E. L. Elson. 1981. Fluorescence photobleaching recovery measurements reveal differences in envelopment of Sindbis and vesicular stomatitis viruses. Cell 23:423.
29. Scher, I. 1982. The CBA/N mouse strain: an experimental model illustrating the influence of the X-chromosome on immunity. Adv. Immunol. 33:1.
30. Dosch, H. M., M. E. Percy, and E. W. Gelfand. 1977. Functional differentiation of B lymphocytes in congenital agammaglobulinemia. I. Generation of hemolytic plaque-forming cells. J. Immunol. 119:1959.
31. + accessory cells are required for the in vitro generation of thymic independent type 2 antibody responses to polysaccharide antigens. J. Immunol. 127:1345.
32. Pinschewer, D. D., A. F. Ochsenbein, A. B. Satterthwaite, O. N. Witte, H. Hengartner, and R. M. Zinkernagel. 1999. A Btk transgene restores the anti-viral T1-2 antibody response of xid mice in a dose-dependent fashion. Eur. J. Immunol. 29:2981.
33. Maloy, K. J., B. Odermatt, H. Hengartner, and R. M. Zinkernagel. 1998. Interferon γ-producing γδ T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection. Proc. Natl. Acad. Sci. USA 95:1160.
34. Bachmann, M. F., T. M. Kündig, C. P. Kalberer, H. Hengartner, and R. M. Zinkernagel. 1993. Formalin inactivation of vesicular stomatitis virus impairs T-cell-but not T-help-independert B-cell responses. J. Virol. 67:3917.
35. Amlot, P. L., D. Grennan, and J. H. Humphrey. 1985. Splenic dependence of the antibody response to thymus-independent (T1-2) antigens. Eur. J. Immunol. 15: 508.
36. Buiting, A. M. J., Z. De Rover, G. Kraal, and N. van Rooijen. 1996. Humoral immune responses against particulate bacterial antigens are dependent on marginal metallophilic macrophages in the spleen. Scand. J. Immunol. 43:398.
37. Goud, S. N., N. Muthusamy, and B. Subbarao. 1988. Differential responses of B cells from the spleen and lymph node to TNP-Ficoll. J. Immunol. 140:2925.
38. Mond, J. J., Q. Vos, A. Lees, and C. M. Snapper. 1995. T cell independent antigens. Curr. Opin. Immunol. 7:349.
39. Baer, G. M., W. J. Bellini, and D. B. Fishbein. 1990. Rhabdoviruses. Raven Press, New York.
40. Hodgkin, P. D. 1997. An antigen valence theory to explain the evolution and organization of the humoral immune response. Immunol. Cell Biol. 75:604.
41. Zinkernagel, R. M., S. Ehl. P. Aichele, S. Oehen, T. M. Kündig, and H. Hengartner. 1997. Antigen localisation regulates immune responses in a dose-and time-dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156:199.
42. Ochsenbein, A. F., P. Klenerman, U. Karrer, B. Ludewig, M. Pericin, H. Hengartner, and R. M. Zinkernagel. 1999. Immune surveillance against a peripheral solid tumor fails because of immunological ignorance. Proc. Natl. Acad. Sci. USA 96:2233.
43. Ochsenbein, A. F., D. D. Pinschewer, B. Odermatt, M. C. Carroll, H. Hengartner, and R. M. Zinkernagel. 1999. Protective T cell-independent antiviral antibody responses are dependent on complement. J. Exp. Med. 190:1165.
44. Spencer, J., M. E. Perry, and D. K. Dunn-Walters. 1998. Human marginal-zone B cells. Immunol. Today 19:421.
45. MacLennan, I. C., A. Gulbranson-Judge, K. M. Toellner, M. Casamayor-Palleja, E. Chan, D. M. Sze, S. A. Luther, and H. A. Orbea. 1997. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol. Rev. 156:53.
46. Zinkernagel, R. M., M. F. Bachmann, T. M. Kündig, S. Oehen, H. Pircher, and H. Hengartner. 1996. On immunological memory. Annu. Rev. Immunol. 14:333.
47. Timens, W., A. Boes, T. Rozeboom-Uiterwijk, and S. Poppema. 1989. Immaturity of the human splenic marginal zone in infancy: possible contribution to the deficient infant immune response. J. Immunol. 143:3200.
48. Breitburd, F., R. Kirnbauer, N.L. Hubbert, B. Nonnenmacher, D. D. Trin, G. Orth, J. T. Schiller, and D. R. Lowy. 1995. Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J. Virol. 69:3959.
49. Milich, D. R., D. L. Peterson, J. Zheng, J. L. Hughes, R. Wirtz, and F. Schodel. 1991. The hepatitis nucleocapsid as a vaccine carrier. Ann. NY Acad. Sci. 31:187.