Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA): Comparison of the acid-base and metal-ion-binding properties of PMEA, (Dien)Pt(PMEA-N1), and (Dien)Pt(PMEA-N7)

Chemistry - A European Journal

Volumn 7, Issue 9, 2001, Pages 1899-1908

  Kampf, Gunnar ^a,b   Lüth, Marc Sven ^b   Kapinos, Larisa E ^a   Müller, Jens ^b   Holý, Antonín ^c   Lippert, Bernhard ^b   Sigel, Helmut ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b TU DORTMUND UNIVERSITY   (Germany)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Acidity constants; DNA; Metal ion complexes; Nucleotides; Stability constants

Indexed keywords

ENZYMES; ETHERS; HYDROGEN BONDS; OXYGEN; PH EFFECTS; PROTONS; TITRATION; ULTRAVIOLET SPECTROPHOTOMETERS;

BINDING SITE;

IONS;

(DIETHYLENETRIAMINE) PLATINUM(II); (DIETHYLENETRIAMINE)-PLATINUM(II); (DIETHYLTRIAMINE)PLATINUM; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE; 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE; ACID; ADEFOVIR; ADENINE; ADENINE DERIVATIVE; ANTIVIRUS AGENT; BASE; CALCIUM; CHELATING AGENT; COPPER; DIETHYLENETRIAMINE; HEAVY METAL; HYDROGEN; ION; LIGAND; MAGNESIUM; METAL; NUCLEOTIDE; PHOSPHONIC ACID DERIVATIVE; PLATINUM COMPLEX; PLATINUM DERIVATIVE; POLYAMINE; PROTON; UNCLASSIFIED DRUG; ZINC;

ACIDITY; ARTICLE; BINDING SITE; CHEMICAL REACTION; CHEMISTRY; COMPARATIVE STUDY; COORDINATION; DRUG STABILITY; HYDROGEN BOND; LIGAND BINDING; METAL BINDING; MOLECULAR STABILITY; PH; SPECTROPHOTOMETRY; SYNTHESIS; TITRIMETRY; ULTRAVIOLET SPECTROSCOPY;

ADENINE; ANTIVIRAL AGENTS; BINDING SITES; CHELATING AGENTS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; METALS, HEAVY; ORGANOPLATINUM COMPOUNDS; PHOSPHONIC ACIDS; POLYAMINES;

EID: 0035805333     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3765(20010504)7:9<1899::AID-CHEM1899>3.0.CO;2-5     Document Type: Article

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